Browsing by Author "Wrzyszcz, Maria"

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IL-10 and TGF- beta cooperate in inducing peripheral T cell tolerance during specific immunotherapy with inhalant allergens and during natural allergen exposure
(Mosby Elsevier, 2001-02) Jutel, Marek; Malolepszy, Josef; Casaulta, Carmen; Wrzyszcz, Maria; Blaser, Kurt; Budak, Ferah; Akdiş, Mübeccel; Akdis, Cezmi; Uludağ Üniversitesi/Tıp Fakültesi/Klinik Immunoloji Anabilim Dalı.; 0000-0001-8020-019X; F-4657-2014; AAV-4844-2020
IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
(Wiley, 2003-02-19) Jutel, Marek; Akdis, M.; Aebischer-Casaulta, C.; Wrzyszcz, Maria; Blaser, Kim M.; Akdis, Cezmi A.; Budak, Ferah; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; F-4657-2014
The regulation of normal and allergic immune responses to airborne allergens in the mucosa is still poorly understood, and the mechanism of specific immunotherapy (SIT) in normalizing the allergic response to such allergens is currently not clear. Accordingly, we have investigated the immunoregulatory mechanism of both normal and allergic responses to the major house-dust mite (HDM) and birch pollen allergens - Dermatophagoides pteroynyssinus (Der p)1 and Bet v 1, respectively - as well as the immunologic basis of SIT to HDM in rhinitis and asthma patients. In normal immunity to HDM and birch pollen, an allergen-specific peripheral T cell suppression to Der p 1 and Bet v 1 was observed. The deviated immune response was characterized by suppressed proliferative T cell and Th1 (IFN-gamma) and Th2 (IL-5, IL-13) cytokine responses, and increased IL-10 and TGF-beta secretion by allergen-specific T cells. Neutralization of cytokine activity showed that T cell suppression was induced by IL-10 and TGF-beta during SIT and in normal immunity to the mucosal allergens. In addition, SIT induced an antigen-specific suppressive activity in CD4(+) CD25(+) T cells of allergic individuals. Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens.
Key role of regulatory cytokines TGF-beta and IL-10 as well as allergen-specific IgA and IgG4 in tolerance to mucosal antigens/allergens
(Mosby- Elsevier, 2002-01) Jutel, Marek; Malolepszy, Josef; Aebischer, Casaultra C.; Wrzyszcz, Maria; Blaser, Kurt; Akdiş, Mübeccel; Budak, Ferah; Akdiş, Cezmi; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; AAV-4844-2020; F-4657-2014
Regulatory cytokines TGF-beta and IL-10 as well as allergen-specific IgA and IgG4 play key role in tolerance to mucosal allergens in aormal immunity and specific immunotherapy
(Wiley, 2002-07) Jutel, Marek; Malolepszy, Jozef; Aebischer, Casaulta C.; Wrzyszcz, Maria; Blaser, Kurt; Budak, Ferah; Akdiş, Mübeccel; Akdis, Cezmi A.; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; 0000-0001-8020-019X; AAV-4844-2020; F-4657-2014