Browsing by Author "Topal, A."

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    How important is the endotracheat tube cuff pressure? A tracheoscopic evaluation in dogs
    (Mezogazda Kiado Kft, 2018-07) Salcı, Hakan; Çetin, M.; Çeşme, H.; Topal, A.; Bayram, Ahmet Sami; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; 0000-0003-0684-0900; T-4623-2019; JJU-7581-2023; GGO-6894-2022; ABB-7580-2020
    Tracheoscopic evaluation of the tracheal mucosa change resulting from different inflating pressure values of the endotracheal tube cuff were performed in this study. Eighteen dogs of different breeds, sexes, ages, and sizes were randomly selected and included in the study. After induction, the dogs were intubated and general anesthesia was maintained with inhalation for surgery. The dogs were randomly grouped according to the following cuff pressures: 25 mmHg in group I (GRI) (n = 6), 50 mmHg in group II (GRII) (n = 6) and random cuff pressures in group III (GRIII) (n = 6). At the end of the surgery, before extubation, tracheoscopies were performed in the dogs. Tracheoscopic examinations revealed mucous fluid accumulation, mucoid plaque, mucosal ruffles, mucosal ischemia, tracheal enlargement, vascular congestion, mucosal hemorrhage and mucosal lacerations. Tracheal lesions were more severe in GRII than in GRI. The underlying tracheal pathologic changes were mucosal nodule, mucosal hyperemia, tracheomalacia and tracheal collapse (grade 1). In conclusion, the endotracheal tube cuff pressure can lead to tracheal lesions; therefore, tracheoscopic examination, if possible, can be used in clinical practice to detect underlying tracheal pathologies before intubation, which can be helpful for preventing tracheal lesions.
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    Tarantula cubensis extract (Theranekron®) inhibits inflammation in carrageenan-induced acute paw edema in rats
    (Arquivo Brasileiro Medicina Veterinaria Zootecnia, 2022-01-01) İpek, Volkan; Özfırat, E. C.; ÖZFIRAT, NEVZAT; Topal, A.; Satar, N. Y. G.; GÜL SATAR, NİHAL YAŞAR; Pamukçular, O.; Uçkan, E. M.; Akkoç A.; AKKOÇ, AHMET; Bursa Uludağ Üniversitesi/Veteriner Fakültesi; 0000-0002-5090-7917; 0000-0001-5874-7797
    The aim of this study was to investigate the anti-inflammatory effect of alcoholic extract of Tarantula cubensis alcoholic extract (TCAE) in experimentally induced inflammation in rats. Fifty-four adult Sprague-Dawley male rats were randomly divided into nine groups. Paw edema was induced by 0.2mL subplantar (s.p.) injection of 1% carrageenan (CAR) into the right hind paw. Rats were treated with the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (INDO) (10mg/kg, p.o.) or TCAE at different doses (1, 10 or 100 mu g/kg) injected s.c. for systemic or s.p. for local anti-inflammatory effect. Saline was used as control. Changes in paw thickness, volume, and weight were calculated as percentages. Formalin-fixed paws were used for histopathological examination. We detected that TCAE applied s.c. at 10 mu g/kg and 100 mu g/kg doses resulted in thinner paw thickness, lower paw volume, and lower paw weights four hours after the induction of inflammation when compared with the INDO group (p<0.05). The paw edema inhibitory effect of TCAE applied at a dose of 10 mu g/kg, s.c. was 68% when compared with the INDO which had an inhibitory effect of 56%. These results were verified with similar histopathological findings. The anti-inflammatory feature of 10 mu g/kg of TCAE given systematically was similar to the effects of INDO. Our results suggest that TCAE has anti-inflammatory effects by reducing edema and decreasing inflammatory reaction. These results may be attributed to the inhibition of the production of proinflammatory mediators. Thus, TCAE may be considered as a potential anti-inflammatory agent for treating acute inflammatory conditions.