Browsing by Author "Seyidoglu, Nilay"
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Publication Dose dependent effects of spirulina platensis on liver health in rats(Agricultural Research Communication Centre, 2020-03-01) Seyidoglu, Nilay; İnan, Sevda; Güneş, Nazmiye; GÜNEŞ, NAZMİYE; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; AAI-1930-2021Spirulina platensis which is an important microalgae is interested in both human and animal nutrition for health balance. This study's aimed to evaluate the dose dependent effects of S.platensis on body weight, height, waist circumference (WC), body mass index (BMI), waist/height ratio (WHtR), abdominal fat weight, liver weight, serum liver enzymes and liver histopathology. 30 male Wistar albino rats're used in groups; Control, SP-1(500mg/kgbw) and SP-2(1000mg/kgbw). S.platensis was administered by oral gavage daily. The body weight, height, WC, BMI, WHtR and abdominal lipid weight were calculated. Also, serum cholesterol, ALT and AST were measured. End of the study, liver tissue samples were taken and scaled and histopathologic changes were recorded. There were no differences in body conditions, but positively significant correlations were found among parameters. As the doses were considered, in groupSP-1, significant positively correlations were determined among abdominal fat, growth, height, BMI and WC statistically. Nevertheless, there were no significant changes in liver weight, serum and histopathologic analyzes. S.platensis with its high concentration of functional nutrients is called as an important alternative therapeutic food and it can be used safely.Item The effect of Saccharomyces cerevisiae on the morphological and histochemical characteristics of the duodenal mucosa in the rabbit(Kafkas Üniversitesi, 2014-01) Peker, Sabire; Seyidoglu, Nilay; Galip, Nurten; Zık, Berrin; Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji Embriyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.; 0000-0002-2817-5131; AAS-2344-2020; AAH-9810-2021; 55109615900; 55921065100; 6603186991; 6507763192The aim of this study was to determine the effect of Saccharomyces cerevisiae (SC) on the morphological and histochemical properties of duodenum and duodenal submucosal glands of rabbits. Twenty 5-6 weeks old male New Zealand White Rabbits were obtained from the experimental animal laboratory of Uludag University, Bursa. The rabbits were divided randomly into two groups for 90 day. The first group (control group) received the basal diet, the second group (SC group) received basal diet supplemented with Saccharomyces cerevisiae at a level of 3 g/kg of feed. Duodenal tissue were taken at the end of the experiment from duodenum of animals and fixed in 10% neutral buffered formalin and embedded in paraffin. Sections were stained for localizing and characterizing glycoproteins (GPs) and morphometric measurements. In this study, the total mucosa, villus heights and gland depth of the duodenum were found to be longer than those of the control group in the SC group. However, duodenal crypt depth was greater in the duodenum of control groups, but no significant difference between the groups. The Goblet cells showed similar reaction in the both groups. Brunner glands were similar stained with AB pH 1, pH 2.5 and PAS/AB pH 1 in the both groups. However, they showed stronger positive reaction with PAS and PAS/AB pH 2.5 staining in the SC group compared with the control. In conclusion, the addition of SC to the diet of rabbits increased the total mucosa, villus height, and gland depth. However, the addition of SC also little affected the histochemical features of the duodenum by increased the secretion neutral and acidic mucins in the Brunner's glands. Therefore, it may be proposed that higher doses of Saccharomyces cerevisiae may be used for digestive health.