Browsing by Author "Rinaldo, Alessandra"
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Item Basaloid squamous cell carcinoma of the upper aerodigestive tract: A single squamous cell carcinoma subtype or two distinct entities hiding under one histologic pattern?(Springer, 2011-02) Woolgar, Julia A.; Lewis, James S., Jr.; Devaney, Kenneth O.; Rinaldo, Alessandra; Takes, Robert P.; Hartl, Dana M.; Ereno Zarate, Cosme; Zbaeren, Peter; Ferlito, Alfio; Coşkun, Hakan H.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 13610800100Item Current philosophy in the surgical management of neck metastases for head and neck squamous cell carcinoma(Wiley, 2015-06) Medina, Jesus E.; Robbins, K. Thomas; Silver, Carl E.; Strojan, Primoz; Teymoortash, Afshin; Pellitteri, Phillip K.; Rodrigo, Juan P.; Stoeckli, Sandro J.; Shaha, Ashok R.; Suarez, Carlos; Hartl, Dana M.; De Bree, Remco; Takes, Robert P.; Hamoir, Marc; Pitman, Karen T.; Rinaldo, Alessandra; Ferlito, Alfio; Çoşkun, Hakan H.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş Boyun Cerrahisi Anabilim Dalı.; 13610800100Neck dissection is an important treatment for metastases from upper aerodigestive carcinoma; an event that markedly reduces survival. Since its inception, the philosophy of the procedure has undergone significant change from one of radicalism to the current conservative approach. Furthermore, nonsurgical modalities have been introduced, and, in many situations, have supplanted neck surgery. The refinements of imaging the neck based on the concept of neck level involvement has encouraged new philosophies to evolve that seem to benefit patient outcomes particularly as this relates to diminished morbidity. The purpose of this review was to highlight the new paradigms for surgical removal of neck metastases using an evidence-based approach.Item Do pathologic and molecular analyses of neck dissection specimens justify the preservation of level IV for laryngeal squamous carcinoma with clinically negative neck?(Elsevier, 2006-02) Elsheikh, Mohamed Nasser; Ferlito, Alfio; Rinaldo, Alessandra; Shaha, Ashok R.; Khafif, Avi; Kowalski, Luiz P.; Medina, Jesus E.; Coşkun, H. Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş Boyun Cerrahisi Anabilim Dalı.; 13610800100Since the first detailed description by Franciszek Jaw-dyn ́ski in 1888,1-4there have been many variations andmodifications of the radical neck dissection procedure.These include modified radical neck dissection (alsocalled functional neck dissection) and various selectiveneck dissections.5-6Analysis of the distribution of lymph node metastasesin patients with squamous carcinoma of the larynx re-veals a marked preference for levels II, III, and IV; levelsI and V are rarely involved.7-9Based on these observa-tions, lateral neck dissection has been recommended inpatients with necks staged as N0 or N1.10This meansremoving the upper jugular lymph nodes (level II), mid-dle jugular lymph nodes (level III), and lower jugularlymph nodes (level IV). Lateral neck dissection is alsodescribed as jugular node dissection by many surgeons.The need for routine dissection at level IV has re-cently been questioned.11This article discusses whethersparing level IV lymph nodes is justified on the strengthof pathologic and molecular studies on the pattern ofnodal metastasis in patients with squamous carcinomaof the larynx. In other words, dare we perform a selectiveneck dissection involving levels IIA and III for N0 necklaryngeal cancer to avoid potential complications such aschylous fistula or phrenic nerve injury?Item Neck treatment and shoulder morbidity: Still a challenge(Wiley, 2011-07) Bradley, Patrick J.; Ferlito, Alfio; Silver, Carl E.; Takes, Robert P.; Woolgar, Julia A.; Strojan, Primoz; Suarez, Carlos; Zbaeren, Peter; Rinaldo, Alessandra; Coşkun, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş Boyun Cerrahisi Anabilim Dalı.; 13610800100Shoulder complaints and functional impairment are common sequelae of neck dissection. This is often attributed to injury of the spinal accessory nerve by dissection or direct trauma. Nevertheless, shoulder morbidity may also occur in cases in which the spinal accessory nerve has been preserved. In this article, the physiology and patho-physiology of the shoulder are discussed, followed by a consideration of the impact of neck dissection on shoulder complaints, functional impairment, and quality of life. Finally, rehabilitation will be considered.Item Prognosis of subglottic carcinoma: Is it really worse?(Wiley, 2019-02) Mendenhall, William M.; Rinaldo, Alessandra; Rodrigo, Juan P.; Suarez, Carlos; Strojan, Primoz; Lopez, Fernando; Mondin, Vanni; Saba, Nabil F.; Shaha, Ashok R.; Smee, Robert; Takes, Robert P.; Ferlito, Alfio; Coşkun, Hakan; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Tıp Bilimleri/Kulak, Burun ve Boğaz Hastalıkları Bölümü.; 13610800100It is traditionally accepted that subglottic carcinoma has a worse prognosis than tumors arising in other subsites of the larynx, owing to its tendency to present in advanced stages, with a high incidence of cartilage invasion and extralaryngeal spread. The incidence of subglottic carcinoma varies among series, mainly because there is no uniform definition of the upper boundary of the subglottis. The extent of the tumor may be difficult to define because subglottic carcinoma may spread through the submucosa without visible mucosal changes. There is also a rich lymphatic network in the subglottis draining to the prelaryngeal and paratracheal lymph nodes, which are usually not involved by cancers arising in other laryngeal subsites. Current literature data indicates that early-stage subglottic carcinoma can be treated using radiotherapy or chemoradiotherapy with high locoregional control and survival rates. In advanced stage subglottic carcinoma, combination of surgery followed by radiotherapy or chemoradiotherapy resulted in comparable outcomes, as in advanced carcinomas from the rest of the larynx. Stage for stage, it is likely that the prognosis for subglottic carcinoma and of glottic and supraglottic cancers is similar.Item Proposal for a rational classification of neck dissections(Wiley, 2011-03) Ferlito, Alfio; Robbins, K. Thomas; Shah, Jatin P.; Medina, Jesus E.; Silver, Carl E.; Al-Tamimi, Shawkat; Fagan, Johannes J.; Paleri, Vinidh; Takes, Robert P.; Bradford, Carol R.; Devaney, Kenneth O.; Stoeckli, Sandro J.; Weber, Randal S.; Bradley, Patrick J.; Suarez, Carlos; Leemans, C. Rene; Pitman, Karen T.; Shaha, Ashok R.; de Bree, Remco; Hartl, Dana M.; Haigentz, Missak, Jr.; Rodrigo, Juan P.; Hamoir, Marc; Khafif, Avi; Langendijk, Johannes A.; Owen, Randall P.; Sanabria, Alvaro; Strojan, Primoz; Poorten, Vincent Vander; Werner, Jochen A.; Bien, Stanislaw; Woolgar, Julia A.; Zbaeren, Peter; Betka, Jan; Folz, Benedikt J.; Genden, Eric M.; Talmi, Yoav P.; Strome, Marshall; Botas, Jesus Herranz Gonzalez; Olofsson, Jan; Kowalski, Luiz P.; Holmes, Jon D.; Hisa, Yasuo; Rinaldo, Alessandra; Coşkun, H. Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 13610800100Item Prospective studies of neck dissection specimens support preservation of sublevel IIB for laryngeal squamous carcinoma with clinically negative neck(Elsevier Science, 2006) Rinaldo, Alessandra; Elsheikh, Mohamed N.; Ferlito, Alfio; Chone, Carlos T.; Köybaşıoğlu, Ahmet; Esclamado, Ramon M.; Corlette, Toby H.; Talmi, Yoav P.; Coşkun, Hakan H.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş Boyun Cerrahisi Anabilim Dalı.; 13610800100A universally accepted independent adverse prognostic factor in head-and-neck squamous carcinoma is presence of cervical lymph node metastases; neck dissection for actual or potentially positive lymph nodes is often indicated. Cervical lymph node metastases can be fatal even if the primary cancer is controlled. Proper neck management in patients with laryngeal squamous carcinoma with no clinical metastases is a subject of much debate and there is no general consensus as to which type of neck dissection is appropriate. Elective neck dissection refers to dissection of cervical lymphatics in the absence of clinical metastatic disease for either staging or treatment purposes. It has been recommended for the N0 neck in patients with T2-T4 supraglottic cancers,1, 2, 3 T3-T4 glottic cancers,3, 4, 5, 6, 7, 8 T3-T4 subglottic cancers,3, 8, 9, 10 and also in patients with recurrent supraglottic and advanced glottic cancers treated with radiotherapy and salvaged with laryngectomy.11 The conventional radical neck dissection policy has been replaced by a more selective approach in the absence of clinically evident metastatic disease.12 Until recently, the procedure of choice for elective operation was modified radical neck dissection (also called functional neck dissection), preserving the sternocleidomastoid muscle, internal jugular vein, and spinal accessory nerve. A number of anatomic, radiographic, pathologic, and clinical studies have demonstrated that metastases from cancer of the larynx occur in levels II to IV, while levels I and V are rarely involved.13, 14, 15, 16 Selective neck dissection (II to IV) (SND), called lateral neck dissection, is now routinely performed for patients with laryngeal cancer in a clinically N0 neck. This surgical procedure has also been indicated recently as SND (II to IV) by the Committee for Head and Neck Surgery and Oncology of the American Academy of Otolaryngology-Head and Neck Surgery.Item Retropharyngeal lymph node metastases in head and neck malignancies(Wiley, 2011-10) Ferlito, Alfio; Medina, Jesus E.; Robbins, K. Thomas; Rodrigo, Juan P.; Strojan, Primoz; Suarez, Carlos; Takes, Robert P.; Woolgar, Julia A.; Shaha, Ashok R.; de Bree, Remco; Rinaldo, Alessandra; Silver, Carl E.; Coşkun, Hakan H.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 13610800100Retropharyngeal lymph node (RPLN) metastasis of primary head and neck cancer often receives less consideration than lymph node metastasis in the neck. With improvements in imaging techniques and reports of surgical pathology, there is an improved understanding of the risk and subsequently the need for treatment of RPLNs. The rates of RPLN metastasis from carcinomas of the nasopharynx, oropharynx, hypopharynx, postcricoid region, maxillary sinus, and cervical esophagus are sufficiently high to warrant routine treatment, either electively or therapeutically, of this region. Through improved diagnostic techniques and heightened awareness of RPLN metastasis, patients at risk of having these metastases can be treated more effectively.Item Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: Systematic review(Elsevier Science, 2018-04) Rodrigo, Juan P.; Grilli, Gianluigi; Shah, Jatin P.; Medina, Jesus E.; Robbins, K. Thomas; Takes, Robert P.; Hamoir, Marc; Kowalski, Luiz P.; Suarez, Carlos; Lopez, Fernando; Quer, Miguel; Boedeker, Carsten C.; de Bree, Remco; Rinaldo, Alessandra; Silver, Carl E.; Ferlito, Alfio; Coşkun, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz - Baş Boyun Cerrahisi Anabilim Dalı.; DVC-7511-2022; 13610800100Adequate treatment of lymph node metastases is essential for patients with head and neck squamous cell carcinoma (HNSCC). However, there is still no consensus on the optimal surgical treatment of the neck for patients with a clinically positive (cN+) neck. In this review, we analyzed current literature about the feasibility of selective neck dissection (SND) in surgically treated HNSCC patients with cN + neck using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. From the reviewed literature, it seems that SND is a valid option in patients with cN1 and selected cN2 neck disease (non-fixed nodes, absence of palpable metastases at level IV or V, or large volume ->3 cm multiple lymph nodes at multiple levels). Adjuvant (chemo) radiotherapy is fundamental to achieve good control rates in pN2 cases. The use of SND instead a comprehensive neck dissection (CND) could result in reduced morbidity and better functional results. We conclude that SND could replace a CND without compromising oncologic efficacy in cN1 and cN2 cases with the above-mentioned characteristics. (C) 2018 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.Item When is reoperative surgery not indicated for recurrent head and neck squamous cell carcinoma?(Springer, 2015-02-01) Rodrigo, Juan P.; Kowalski, Luiz P.; Silver, Carl E.; de Bree, Remco; Rinaldo, Alessandra; Shaha, Ashok R.; Strojan, Primoz; Elsheikh, Mohamed N.; Haigentz, Missak, Jr.; Sanabria, Alvaro; Takes, Robert P.; Ferlito, Alfio; Coşkun, H. Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun ve Boğaz Hastalıkları Anabilim Dalı.; EQK-3127-2022; 13610800100