Browsing by Author "Omma, Ahmet"
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Item Assessment of damage and prognosis in patients with adult iga vasculitis: Retrospective multicentered cohort study(Bmj Publishing Group, 2017-06) Alibaz, Öner; Omma, Ahmet; Sarı, Alper; Karadağ, Ömer; Cansu, Döndü Üsküdar; Beş, Cemal; Yıldız, Fatih; Yılmaz, Sema; Balkarlı, Ayşe; Üreyen, S.; Direskeneli, Haner; Öksüz, Mustafa Ferhat; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.Item Assessment of severity and risk factors of post-thrombotic syndrome in vascular behcet disease: Muticentered retrospective study(Wiley, 2018-09) Aksoy, Aysun; Çolak, Seda; Omma, Ahmet; Ergelen, Rabia; Direskeneli, Haner; Alibaz, Fatma Öner; Yağız, Burcu; Coşkun, Belkıs Nihan; Bolca, Naile; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0003-0298-4157; AAG-7155-2021Publication Assessment of severity and risk factors of post-thrombotic syndrome in vascular Behcet disease: muticentered retrospective study(Clinical and Experimental Rheumatology, 2018) Aksoy, Aysun; Çolak, Seda; Omma, Ahmet; Ergelen, Rabia; Direskeneli, Rafi Haner; Alibaz, Öner Fatma; Yağız, Burcu; Coşkun, Belkıs Nihan; Bolca, Naile; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Bilim Dalı; 0000-0003-0298-4157; JQW-5031-2023; AAG-7155-2021; EKW-9201-2022Item Behçet disease with vascular involvement: Effects of different therapeutic regimens on the incidence of new relapses(Lippincott Williams & Wilkins, 2015-02) Öner, Fatma Alibaz; Karadeniz, Aslı; Yılmaz, Sema; Balkarlı, Ayşe; Kimyon, Gezmiş; Yazıcı, Ayten; Çınar, Muhammet; Yılmaz, Sedat; Yıldız, Fatih; Bilge, Şule Yaşar; Bilgin, Emre; Omma, Ahmet; Çetin, Gözde Yıldırım; Çağatay, Yonca; Karaaslan, Yaşar; Sayarlıoğlu, Mehmet; Kalyoncu, Umut; Karadağ, Ömer; Kaşifoğlu, Timuçin; Erken, Eren; Pay, Salih; Çefle, Ayşe; Kısacık, Bünyamin; Onat, Ahmet Mesut; Çobankara, Veli; Direskeneli, Haner; Coşkun, Belkıs Nihan; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; 0000-0003-0298-4157; AAG-7155-2021; AAG-8227-2021; 55646165400; 13205593600Vascular involvement is one of the major causes of mortality and morbidity in Behcet disease (BD). There are no controlled studies for the management of vascular BD (VBD), and according to the EULAR recommendations, only immunosuppressive (IS) agents are recommended. In this study, we aimed to investigate the therapeutic approaches chosen by Turkish physicians during the initial event and relapses of VBD and the association of different treatment options with the relapses retrospectively. Patients with BD (n = 936, female/male: 347/589, mean age: 37.6 +/- 10.8) classified according to ISG criteria from 15 rheumatology centers in Turkey were included. The demographic data, clinical characteristics of the first vascular event and relapses, treatment protocols, and data about complications were acquired. VBD was observed in 27.7% (n = 260) of the patients during follow-up. In 57.3% of the VBD patients, vascular involvement was the presenting sign of the disease. After the first vascular event, ISs were given to 88.8% and AC treatment to 59.8% of the patients. Median duration of AC treatment was 13 months (1-204) and ISs, 22 months (1-204). Minor hemorrhage related to AC treatment was observed in 7 (4.7%) patients. Asecond vascular event developed in 32.9% (n = 86) of the patients. The vascular relapse rate was similar between patients taking only ISs and AC plus IS treatments after the first vascular event (29.1% vs 22.4%, P = 0.28) and was significantly higher in group taking only ACs than taking only ISs (91.6% vs 29.1%, P < 0.001). During follow-up, a third vascular event developed in 17 (n = 6.5%) patients. The relapse rate was also similar between the patients taking only ISs and AC plus IS treatments after second vascular event (25.3% vs 20.8%, P = 0.93). When multivariate analysis was performed, development of vascular relapse negatively correlated with only IS treatments. We did not find any additional positive effect of AC treatment used in combination with ISs in the course of vascular involvement in patients with BD. Severe complications related to AC treatment were also not detected. Our results suggest that short duration of IS treatments and compliance issues of treatment are the major problems in VBD associated with vascular relapses during follow-up.Item Current smoking is increased in axial psoriatic arthritis and radiographic sacroiliitis(Journal of Rheumatology Publishing Co., 2020-09-01) Solmaz, Dilek; Kalyoncu, Umut; Tinazzi, Ilaria; Bakirci, Sibel; Bayindir, Ozun; Dogru, Atalay; Omma, Ahmet; Can, Meryem; Yilmaz, Sema; Erden, Abdulsamet; Aydın, Sibel Zehra; Dalkılıç, Ediz; Uludağ Üniversitesi/İç Hastalıkları Bölümü/Romatoloji Anabilim Dalı; CMF-4757-2022; 6506739457OBJECTIVE: This study aims to examine how internalized stigma differs in opioid use disorder (OUD) based on sociodemographic and clinical variables, and to what extent internalized stigma is related to treatment motivation, perceived social support, depression, and anxiety levels. METHODS: One hundred forty-five individuals with OUD included. Sociodemographic and clinical data form, the Internalized Stigma of Mental Illness Scale (ISMI), Treatment Motivation Questionnaire (TMQ), Multidimensional Scale of Perceived Social Support, the Beck Depression Inventory, and the Beck Anxiety Inventory were utilized in the study to collect data. Bivariate and partial correlation coefficients between variables were computed. ISMI and TMQ scores were compared between patients with depressive symptoms and patients without depressive symptoms by using t-test and Mann Whitney U test. RESULTS: Internalized stigma was high among male patients with heroin use disorder. There was a positive correlation between internalized stigma score and treatment motivation, depression, and anxiety levels. On the other hand, there was a negative correlation between internalized stigma score and multidimensional perceived social support. CONCLUSION: Internalized stigma occupies an important place in the treatment of OUD, which occurs with frequent relapses and which is hard to treat. Not only application for treatment but also adherence to treatment and treatment motivation at maintenance phase bestow a complicated relationship with depression and anxiety. In the struggle against internalized stigma, it plays a vital role to mobilize people’s social support systems, to educate families on the issue and to get in touch with support units exclusive to heroin users.Publication Predictors for the risk and severity of post-thrombotic syndrome in vascular Behcet's disease(Elsevier, 2021-02-04) Aksoy, Aysun; Çolak, Seda; Yağız, Burcu; Coşkun, Belkıs Nihan; Omma, Ahmet; Yıldız, Yasin; Sarı, Alper; Ataş, Nuh; Ilgın, Can; Karadağ, Ömer; Erden, Abdulsamet; Dalkılıç, Ediz; Bolca, Naile; Ergelen, Rabia; Onur, Mehmet Ruhi; Direskeneli, Haner; Alibaz-Öner, Fatma; YAĞIZ, BURCU; COŞKUN, BELKIS NİHAN; BOLCA TOPAL, NAİLE; DALKILIÇ, HÜSEYİN EDİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0003-0298-4157; JQW-5031-2023; AAG-7155-2021; CMF-4757-2022 ; EKW-9201-2022Objective: Deep vein thrombosis (DVT) of the lower extremities is the most common form of vascular involvement in Behcet disease (BD), frequently leading to post-thrombotic syndrome (PTS) as a disabling complication. We have described the clinical characteristics and predictors of PTS presence among patients with BD and lower extremity DVT. We also used venous Doppler ultrasound (US) examinations in our assessment. Methods: Patients with BD (n = 205; 166 men, 39 women; age 39 6 9.5 years) and a history of DVT were investigated. The Villalta scale was used to assess the presence and severity of PTS. Doppler US examinations were performed within 1 week of the clinical evaluation. The total number of vessels with reflux, thrombi, recanalization, and collateral vessels were calculated. Results: Of the 205 patients with BD, 62% had had PTS and 18% had had severe PTS. Patients with PTS had had greater reflux (P = .054) and thrombosis (P = .02) scores compared with patients without PTS. Treatment with anticoagulation (AC), immunosuppressive (IS) therapy, or AC combined with IS drugs did not affect the occurrence of PTS. However, patients treated with IS therapy, with or without AC drugs, had a decreased incidence of severe PTS compared with the AC-only group (P = .017). Patients treated with AC plus IS agents also had increased collateral scores compared with patients treated with only IS drugs. Interferon-a use seemed to provide better recanalization scores compared with azathioprine only (1.0 [range, 0-14] vs 2.5 [range, 0-10]; P = .010). Conclusions: Patients with BD and DVT have a high risk of developing severe PTS. IS treatment decreases the development of severe PTS. AC therapy might influence the course of PTS by increasing the collateral scores, and the use of interferon-a also increased recanalization scores. Routine assessment with Doppler US examinations could be helpful in the prediction of severe PTS.Publication Psart-id inception cohort: Clinical characteristics, treatment choices and outcomes of patients with psoriatic arthritis(Oxford University, 2021-04-01) Ayan, Gizem; Aydin, Sibel Zehra; Kimyon, Gezmis; Ozisler, Cem; Tinazzi, Ilaria; Dogru, Atalay; Omma, Ahmet; Kilic, Levent; Kucuksahin, Orhan; Gonullu, Emel; Can, Meryem; Ylldlz, Fatih; Solmaz, Dilek; Bayindir, Ozun; Esmen, Serpil Ergulu; Ersozlu, Emine Duygu; Duruoz, Mehmet Tuncay; Akyol, Lutfi; Kucuk, Adem; Bes, Cemal; Erden, Abdulsamet; Bakirci, Sibel; Kasifoglu, Timucin; Kalyoncu, Umut; Balkarli, Aye; Dalkilic, Ediz; Cetin, Gozde Yildirim; Cinar, Muhammet; Mercan, Ridvan; Yazisiz, Veli; Dalkılıç, Ediz; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-1889-9619; 0000-0001-7475-3927; 0000-0002-6990-4206; 0000-0003-3628-8870; 0000-0002-9035-689X; 0000-0003-3584-2788; 0000-0001-8028-1671; 0000-0002-8084-2018; 0000-0002-2745-7700; 0000-0001-9680-7535; 0000-0002-6150-3539; GQQ-3193-2022; I-2307-2016; W-2397-2019; K-7985-2019; B-1448-2016; AAK-7851-2021; HLP-4890-2023; GZA-3287-2022; P-2555-2018; C-1808-2016Objectives. Our aim is to understand clinical characteristics, real-life treatment strategies, outcomes of early PsA patients and determine the differences between the inception and established PsA cohorts.Methods. PsArt-ID (Psoriatic Arthritis- International Database) is a multicentre registry. From that registry, patients with a diagnosis of PsA up to 6 months were classified as the inception cohort (n=388). Two periods were identified for the established cohort: Patients with PsA diagnosis within 5-10 years (n = 328), >= 10 years (n = 326). Demographic, clinical characteristics, treatment strategies, outcomes were determined for the inception cohort and compared with the established cohorts.Results. The mean (S.D.) age of the inception cohort was 44.7 (13.3) and 167/388 (43.0%) of the patients were male. Polyarticular and mono-oligoarticular presentations were comparable in the inception and established cohorts. Axial involvement rate was higher in the cohort of patients with PsA >= 10 years compared with the inception cohort (34.8% vs 27.7%). As well as dactylitis and nail involvement (P = 0.004, P = 0.001 respectively). Both enthesitis, deformity rates were lower in the inception cohort. Overall, 13% of patients in the inception group had a deformity. MTX was the most commonly prescribed treatment for all cohorts with 10.7% of the early PsA patients were given anti-TNF agents after 16 months.Conclusion. The real-life experience in PsA patients showed no significant differences in the disease pattern rates except for the axial involvement. The dactylitis, nail involvement rates had increased significantly after 10 years from the diagnosis and the enthesitis, deformity had an increasing trend over time.Item What are the main barriers to achieve minimal disease activity in psoriatic arthritis in real life?(Clinical & Exper Rheumatology, 2019-09) Bakırcı, Sibel; Solmaz, Dilek; Al Osaimi, Noura; Can, Meryem; Erden, Abdulsamed; Özişler, C.; Çınar, Muhammet; Kılıç, Levent; Küçük, A.; Omma, Ahmet; Yıldız, Fatih; Doğru, Atalay; Esmen, Serpil Ergülü; Akar, Servet; Kalyoncu, Umut; Aydın, Sibel Zehra; Tufan, Abdurrahman; Dalkılıç, Ediz; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Bilim Dalı.; CMF-4757-2022; 6506739457Objective: Minimal disease activity (MDA) is an important target in patients with psoriatic arthritis (PsA), however it is also criticised for having a low threshold for patient reported outcomes (PRO). The aim of the study was to assess the prevalence of MDA and its components in patients with PsA and to evaluate disease characteristics and patterns in patients with or without MDA (MDA(+) or MDA(-)).MethodsPsArt-ID (Psoriatic Arthritis-International Database) is a prospective, multicentre web-based registry. PsA patients who had at least 1 year of disease duration and had full data for MDA were included for this analysis (n=317). Patients were considered in MDA+ when they met at least 5/7 of the MDA criteria.ResultsMDA was achieved in 46% patients. Within MDA- patients, body surface area (51.2%) and swollen joint count (53.5%) domains could still be achieved in the majority and 93.5% of them had no enthesitis using the Leeds enthesitis index. Of 170 patients with MDA-, 90 patients did not fulfill all 3 PROs of MDA. Mono-arthritis subtype (RR: 2.01), absence of enthesitis (RR: 1.570) and absence of distal interphalangeal (DIP) joint disease (RR: 1.1) were associated with higher probability of achieving MDA.ConclusionThe MDA criteria provide an objective target for treatment in trials and clinical practice; however, in real life PROs are the most significant barriers to achieve MDA. The presence of DIP joints disease makes it difficult to reach MDA due to active PROs.