Browsing by Author "Mitamura, Yasutaka"

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Dysregulation of the epithelial barrier by environmental and other exogenous factors
(Wiley, 2021-08-18) Mitamura, Yasutaka; Öğülür, İsmail; Pat, Yağız; Rinaldi, Arturo O.; Ardıçlı, Özge; Cevhertaş, Laçin; Brueggen, Marie-Charlotte; Traidl-Hoffmann, Claudia; Akdiş, Mübeccel; Akdiş, Cezmi A.; ARDIÇLI, ÖZGE; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Tıbbi İmmünoloji Anabilim Dalı.; AAG-7421-2021; FYD-1431-2022
The "epithelial barrier hypothesis" proposes that the exposure to various epithelial barrier-damaging agents linked to industrialization and urbanization underlies the increase in allergic diseases. The epithelial barrier constitutes the first line of physical, chemical, and immunological defense against environmental factors. Recent reports have shown that industrial products disrupt the epithelial barriers. Innate and adaptive immune responses play an important role in epithelial barrier damage. In addition, recent studies suggest that epithelial barrier dysfunction plays an essential role in the pathogenesis of the atopic march by allergen sensitization through the transcutaneous route. It is evident that external factors interact with the immune system, triggering a cascade of complex reactions that damage the epithelial barrier. Epigenetic and microbiome changes modulate the integrity of the epithelial barrier. Robust and simple measurements of the skin barrier dysfunction at the point-of-care are of significant value as a biomarker, as recently reported using electrical impedance spectroscopy to directly measure barrier defects. Understanding epithelial barrier dysfunction and its mechanism is key to developing novel strategies for the prevention and treatment of allergic diseases. The aim of this review is to summarize recent studies on the pathophysiological mechanisms triggered by environmental factors that contribute to the dysregulation of epithelial barrier function.
Effect of altered human exposome on the skin and mucosal epithelial barrier integrity
(Taylor & Francis Inc, 2022-10-21) Pat, Yagiz; Oğulur, İsmail; Yazici, Duygu; Mitamura, Yasutaka; Cevhertaş, Laçin; Kucukkase, Ozan C.; Mesisser, Sanne S.; Akdis, Mubeccel; Nadeau, Kari; Akdis, Cezmi A.; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Tıbbi İmmünoloji Anabilim Dalı.; FYD-1431-2022
Pollution in the world and exposure of humans and nature to toxic substances is continuously worsening at a rapid pace. In the last 60 years, human and domestic animal health has been challenged by continuous exposure to toxic substances and pollutants because of uncontrolled growth, modernization, and industrialization. More than 350,000 new chemicals have been introduced to our lives, mostly without any reasonable control of their health effects and toxicity. A plethora of studies show exposure to these harmful substances during this period with their implications on the skin and mucosal epithelial barrier and increasing prevalence of allergic and autoimmune diseases in the context of the "epithelial barrier hypothesis". Exposure to these substances causes an epithelial injury with peri-epithelial inflammation, microbial dysbiosis and bacterial translocation to sub-epithelial areas, and immune response to dysbiotic bacteria. Here, we provide scientific evidence on the altered human exposome and its impact on epithelial barriers.