Browsing by Author "Lopez, Fernando"
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Item Prognosis of subglottic carcinoma: Is it really worse?(Wiley, 2019-02) Mendenhall, William M.; Rinaldo, Alessandra; Rodrigo, Juan P.; Suarez, Carlos; Strojan, Primoz; Lopez, Fernando; Mondin, Vanni; Saba, Nabil F.; Shaha, Ashok R.; Smee, Robert; Takes, Robert P.; Ferlito, Alfio; Coşkun, Hakan; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Tıp Bilimleri/Kulak, Burun ve Boğaz Hastalıkları Bölümü.; 13610800100It is traditionally accepted that subglottic carcinoma has a worse prognosis than tumors arising in other subsites of the larynx, owing to its tendency to present in advanced stages, with a high incidence of cartilage invasion and extralaryngeal spread. The incidence of subglottic carcinoma varies among series, mainly because there is no uniform definition of the upper boundary of the subglottis. The extent of the tumor may be difficult to define because subglottic carcinoma may spread through the submucosa without visible mucosal changes. There is also a rich lymphatic network in the subglottis draining to the prelaryngeal and paratracheal lymph nodes, which are usually not involved by cancers arising in other laryngeal subsites. Current literature data indicates that early-stage subglottic carcinoma can be treated using radiotherapy or chemoradiotherapy with high locoregional control and survival rates. In advanced stage subglottic carcinoma, combination of surgery followed by radiotherapy or chemoradiotherapy resulted in comparable outcomes, as in advanced carcinomas from the rest of the larynx. Stage for stage, it is likely that the prognosis for subglottic carcinoma and of glottic and supraglottic cancers is similar.Item Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: Systematic review(Elsevier Science, 2018-04) Rodrigo, Juan P.; Grilli, Gianluigi; Shah, Jatin P.; Medina, Jesus E.; Robbins, K. Thomas; Takes, Robert P.; Hamoir, Marc; Kowalski, Luiz P.; Suarez, Carlos; Lopez, Fernando; Quer, Miguel; Boedeker, Carsten C.; de Bree, Remco; Rinaldo, Alessandra; Silver, Carl E.; Ferlito, Alfio; Coşkun, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz - Baş Boyun Cerrahisi Anabilim Dalı.; DVC-7511-2022; 13610800100Adequate treatment of lymph node metastases is essential for patients with head and neck squamous cell carcinoma (HNSCC). However, there is still no consensus on the optimal surgical treatment of the neck for patients with a clinically positive (cN+) neck. In this review, we analyzed current literature about the feasibility of selective neck dissection (SND) in surgically treated HNSCC patients with cN + neck using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. From the reviewed literature, it seems that SND is a valid option in patients with cN1 and selected cN2 neck disease (non-fixed nodes, absence of palpable metastases at level IV or V, or large volume ->3 cm multiple lymph nodes at multiple levels). Adjuvant (chemo) radiotherapy is fundamental to achieve good control rates in pN2 cases. The use of SND instead a comprehensive neck dissection (CND) could result in reduced morbidity and better functional results. We conclude that SND could replace a CND without compromising oncologic efficacy in cN1 and cN2 cases with the above-mentioned characteristics. (C) 2018 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.