Browsing by Author "Kasap, Sevim"
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Item Alimentary lymphoma in a cat(Bursa Uludağ Üniversitesi, 2018-05-18) Karakuş, Adil Ömer; Kasap, Sevim; Mutlu, Ayşe Meriç; Tavus, Melike Akbala; Salcı, Hakan; Sönmez, Gürsel; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.Lymphoma is the most common feline malignant tumor, and the alimentary form is the most common seen form. Alimentary form in the cat typically involves lesions of the small intestine, stomach, mesenteric lymph nodes, and liver. The disease is often reported in cats between 1 and 20 (mean 13 years) years. A 3-year-old domestic male cat was admitted to Uludağ University Animal Hospital due to chronic weight loss, loss of appetite, diarrhea and vomiting traced back to 15 days. Abdominal ultrasonography was performed and a large solid mass was spotted in the cranial abdomen. During the treatment, the cat developed respiratory stress, shock and died 2 days after. In light of the clinical symptoms, ultrasonography, necropsy and histopathological findings; small-cell-alimentary lymphoma was diagnosed for the 3-year-old cat. It can be interpreted that small cell (lymphocytic) alimentary lymphoma is seen rarely in younger cats and seldomItem Atların alt solunum yolu hastalıklarında trakeal aspirasyon örneklerinin bakteriyolojik ve sitolojik muayene bulgularının klinik ve hematolojik bulgularla ilişkilendirilerek değerlendirilmesi(Uludağ Üniversitesi, 2012) Kasap, Sevim; Kennerman, Engin; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/İç Hastalıkları Anabilim Dalı.Bu çalışmada, alt solunum yolları hastalığı bulunan atlarda trakeal aspirasyon örneklerinin sitolojik ve bakteriyolojik muayenelerinin, hematolojik ve klinik muayene bulguları ile ilişkilendirilmesi amaçlanmıştır.Çalışmada; her iki cinsiyetten, farklı yaş ve ırklarda (İngiliz ve Arap ırkı), klinik olarak hastalık belirtisi gösteren toplam 50 adet at kullanıldı. Atların klinik muayenelerini takiben, endoskopik muayene eşliğinde trakeal aspirasyon tekniği ile alınan örneklerin sitolojik ve bakteriyolojik muayeneleri yapıldı. Trakeal aspirasyon dışında atlardan kan alınarak hematolojik bulguları değerlendirildi.Anamnez, klinik bulgular ve endoskopik muayeneler temelinde klinik skorlandırma yapılarak, klinik skoru 5 ve üzeri olan vakalar değerlendirmeye alındı. Endoskopi eşliğinde uygulanan trakeal aspirasyon tekniğiyle alınan örneklerden froti hazırlanarak Wright-Giemsa ile boyandı. Sitolojik muayenede, bakteri izole edilen örnekler ile izole edilmeyen örnekler karşılaştırdı.Klinik skorlandırma sonuçlarına göre en az klinik skor 6, en fazla ise 26 olarak belirlendi. Değerlendirmenin sonucunda 6-10 arasında 15, 11-15 arası 24, 16-20 arası ise 11 at tespit edildi. Alt solunum yolları hastalığı olan atlardan yapılan hematolojik bulgularda 1 vakada lökositoz tablosu, 7 adet vakada band nötrofil düzeyinde hafif artış, 4 adet vakada ise monositoz tablosu olduğu belirlendi. Trakeal örneklerin sitolojik muayenelerine göre etken üreyen vakalarda etken üremeyen vaklara göre nötrofil, makrofaj (p<0,001) ve lenfosit hücrelerinin (p<0,05) yüzdelik oranları arasında istatistiki olarak önem bulundu.Alınan aspirasyon sıvısından yapılan bakteriyolojik muayene sonucunda 50 atın 36 'sinde Streptococcus equi subsp zooepidemicus (14), Staphylococcus lentus (4), Staphylococcus sp (1), Staphylococcus equarum (1), Staphylococcus sciuri (1), Staphylococcus vitilus (1), Staphylococcus saprophyticus (1), Staphylococcus gallinarum (1), Staphylococcus haemolyticus (2), Shewanella putrefaciens (1), Stenotrophomonas maltophilia (1), Escherichia coli (8) etkenleri çoğunlukta olmak üzere toplamda 51 adet aerobik/fakültatif gram (+) kok ve gram (-) basil grubunda bakteri üremesi tespit edildi. Etken izolasyonlarına göre antibiyogram değerlendirilmeleri yapıldı. Streptococcus equi subsp zooepidemicus izole edilen örneklerde ampisillin, Staphylococcus lentus ve diğer Staphylococcus etkenlerine karşı polimiksin B ve rifampisin ve Gram (-) basil grubunda yer alan E.coli'nin ise florfenikole duyarlılığın daha fazla olduğu belirlendi.Sunulan çalışmada bakteri izole edilen trakeal örneklerin sitolojik değerlendirmelerinde, bakteri izole edilmeyenlere göre belirlenen fark, tanı aşamasında sitolojik değerlendirmenin önemini vurgulamaktadır. Hematolojik parametrelerde belirgin bir anormalitenin belirlenmemesi hemogram bulgularının; özellikle atların solunum sistemi problemlerinin başlangıç safhasında, anamnez, klinik ve endoskopik muayene eşliğinde değerlendirilmesi gerekliliğini düşündürmektedir. Sonuç olarak atların alt solunum yolları hastalıklarında, özellikle endoskopi eşliğinde yapılan trakeal aspirasyon tekniğinin gerek sitolojik değerlendirme, gerekse etken identifikasyonu açısından kullanışlı olduğu kanısına varıldı.Item Botulism (type A) in a horse - case report(Veterinarni a Farmaceuticka Univerzita Brno, 2016-02-10) Gessler, Frank; Kasap, Sevim; Batmaz, Hasan; Kocatürk, Meriç; Çatık, Serkan; Topal, Onur; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; 0000-0003-1991-8957; 0000-0002-1933-7354; AAP-7998-2020; AAH-1712-2021; S-8278-2017; V-5578-2017; 36514844800; 6602783183; 36437200800; 56515323800; 56548777100This paper presents the case of a six year-old, male, thoroughbred horse with clinical signs of inappetence, weakness, and incoordination when walking. Clinical examination showed that the horse staggered and leaned to the left side. Feedstuff was present inside and around its mouth. Salivation was increased and there was no reflex at the palpebrae and tongue. The horse had difficulty swallowing and the tone of its tail was reduced. Botulism was diagnosed based on the clinical signs. Antibiotic (ceftiofur) and fluid-electrolyte treatment was commenced. Next day, neostigmin was added to the horse's treatment, and it became recumbent. The horse's palpebral, tongue and tail reflexes returned partially after neostigmine methylsulphate treatment on the same day and it stood up on day four. However, it could not swallow anything during the whole week, so after getting permission from the owner, the horse was euthanized on day 10. Samples of the colonic content and blood serum were sent by courier to the laboratory for toxin neutralization, however, botulinum neurotoxins could not be detected. After that, serum samples from days 6 and 10 were sent to another laboratory for testing for botulinum neurotoxin antibodies by ELISA. Specific antibodies against botulinum neurotoxin type A were measured, indicating a previous, immuno-relevant contact with the toxin. This seroconversion for type A supports the clinical botulism diagnosis. Type A botulism is rarely seen in Europe and has been detected in a horse in Turkey for the first time.Item Changes in circulating adiponectin and tumour necrosis factor-alpha and their relationship with insulin resistance in periparturient dairy cows(Sciendo, 2016-05-13) Mecitoğlu, Zafer; Şentürk, Sezgin; Akgül, Gülsah; Udum, Duygu; Uzabacı, Ender; Kasap, Sevim; Çatık, Serkan; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0001-7052-1694; 0000-0002-2465-9913; 0000-0002-5557-121X; 0000-0002-9634-0055; AAH-5167-2021; AAH-5069-2021; AAH-1677-2021; AAP-7998-2020; 36457647300; 56257771200; 56604015400; 31967936400; 55347697800; 36514844800; 56515323800Introduction: The aim of the study was to investigate changes in the serum levels of adiponectin and TNF-alpha, as well as insulin sensitivity, and to elucidate the possible relationship among the parameters and negative energy balance during the periparturient period of dairy cows. Material and Methods: Thirty primiparous Holstein dairy cows were selected for the study. Blood samples were collected from each cow seven days before the expected calving date, on the calving day, and 7, 14, and 21 days after calving. Blood non-esterified fatty acids (NEFA), beta-hydroxybutyric acid (BHBA), glucose, insulin, adiponectin, and TNF- alpha levels were measured. Revised Quantitative Insulin Sensitivity Check Index (rQUICKI) was calculated using data on NEFA, insulin, and glucose concentrations. Results: When compared to prepartum levels, serum concentration of adiponectin significantly increased on day 21 postpartum. The rQUICKI increased and NEFA levels decreased on day 7 after parturition. Insulin and glucose levels decreased on days 7, 14, and 21 postpartum when compared with prepartum levels. BHBA levels decreased on day 21 and TNF- alpha concentration also decreased on days 7, 14, and 21 postpartum. Adiponectin levels positively correlated with NEFA during the preparturient period. Negative correlation was detected between adiponectin and rQUICKI on calving day and on 14th day after parturition. TNF- alpha concentration positively correlated with glucose levels on day 7 prepartum and on 21st day postpartum and with rQUICKI on 21st day postpartum. Negative correlation was detected between adiponectin level and insulin sensitivity. Conclusion: Based on the results of the study, we concluded that adiponectin could possibly increase insulin sensitivity when blood NEFA concentrations are elevated.Item Clinical and biochemical evaluation of cows occurring severe weight loss after calving(Uludağ Üniversitesi, 2010-04-05) Şentürk, Sezgin; Mecitoğlu, Zafer; Temizel, Mutlu; Cihan, Hüseyin; Kasap, Sevim; Demir, Gülşah; Uludağ Üniversitesi/Veteriner Fakültesi.This study was designed to observe the biochemical and clinical changes in Holstein cows suffering from severe weight loss after calving. Clinically, out of the 75 milking cows in the first 8 week postpartum examined, 25 cows aged 4– 8 years were found to be suffering from decreased milk production, severe body weight loss. 25 healthy cows in the same period after calving, aged 4 – 8 years, were also used as a control group. Serum biochemistry analyses including potassium (K), sodium ( Na), calcium (Ca), phosphorus (P), magnesium (mg), albumin, alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), total biluribin, (TBIL) total protein (TP), creatinine (Cre), blood urea nitrogen (BUN), and β-Hydroxybutyrate (BHBA) were evaluated. Body condition score (BCS) of 17 of 25 cows, severe weight loss after calving cows, was ≤ 2.0 and BCS of 8 cows was between 2.0 and 3.0. BCS of Animals in the control group were determined as range: 3.5 -4.0. Endometritis in 11 cows, subclinical mastitis in 8 cows, clinical ketosis in 5 cows, sub clinical ketosis in 20 cows, and left displaced abomasum in 3 cows were determined. Identical points of 25 animals were higher BHB, GGT, AST, total globulin, and total protein levels according to healthy cows and references values. In addition, these cows had hypoalbunemi and hypocalcaemia, when compared with healthy cows. The results of the study reported here indicated that metabolic profile including serum BHBA, calcium, albumin, GGT, AST, total protein, should be evaluated to determine the causes of severe weight loss, and decreased yield in cows after calving.Item Clinical, haematological and biochemical findings in Saanen goat kids with naturally occurring heat stroke(George Thieme, 2009) Temizel, Ethem Mutlu; Şentürk, Sezgin; Kasap, Sevim; Uludağ Üniversitesi/Veteriner Fakültesi/Uluslararası Tıp Anabilim Dalı.; Uludağ Üniversitesi/Hayvan Hastanesi/Dahiliye Bölümü.; 0000-0002-2465-9913; AAP-7998-2020; AAH-5069-2021; 26430270100; 56257771200; 36514844800Objective: Description of clinical, biochemical and haematological changes in Saanen goat kids post-exposure to a naturally occurring heatstroke. Material and methods:The experimental group consisted of goats of different age (1-4 months) and sex (8 males, 12 females) with an average weight of 7.2 +/- 3.1 kg. Twenty clinically healthy, three to four months old, Saanen goat kids (sex-ratio 1:1) were used as a control. The average body weight in this group was 9.4 +/- 2.6 kg. Case history, clinical signs, and results of haematology and blood biochemistry were documented in all goat kids. Results: Most common findings were hyperthermia, ataxia, muscle tremor and depression. Increased serum urea, creatinine, potassium and plasma lactate concentrations as well as an increase in aspartate aminotransferase and lactate dehydrogenase activity were observed in goats post-exposure to heat stroke when compared to the control group. Two goat kids died despite supportive treatment. Physical and biochemical blood parameters improved following treatment. Conclusion: This is the first study on heat stroke in Saanen goat kids. Heatstroke may be fatal in Saanen goat kids, despite appropriate treatment, and may lead to secondary complications. Plasma lactate concentration seems to be a reliable indicator for the prognosis of heat stroke in goat kids.Publication Comparison of beta-hydroxybutyrate levels in the first three weeks after calving in four healthy different breeds of cows(Bursa Uludağ Üniversitesi, 2023-01-18) CİHAN, HÜSEYİN; KASAP, SEVİM; ŞENTÜRK, SEZGİN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; 0000-0003-1544-6438; 0000-0001-9501-9983; 0000-0002-2465-9913The objective of this study was to determine the differences between the healthy Holsteın-Friesian, Jersey, Simmental, and Aberdeen Angusbreeds Beta-hydroxybutyrate (BHBA) levels at the first three weeks after calving. The blood samples were collected for analysis between 10-20 days postpartum. In this study, 80 animals were used in different regions in total. BHBA was analyzed by Ketosite® (Ketosite®, Stanbio LabrotoryInc., Boerne, TX USA). Milk fat and protein levels were immediately measured by an electronic milk analyzer (Milkoscan FT1 FOSS Industries, Denmark). Statistical analyses of the study were performed using Sigma Plot 12 (Systat Software Inc., San Lose, CA). The means of BHBA levelswere compared by One Way Anova. As in Holstein cows, blood BHBA levels increased in the early lactation period and also in other breeds. Theresults of this study presented that serum BHBA levels were significantly higher in Holsteın-Friestein cows than in Simmental and AberdeenAngus cows.Item Comparison of effectiveness of parenteral lincomycin/spectinomycin combination and dexpanthenol application in goat kids with contagious ecthyma(Polish Soc Veterinary Sciences Editorial Office, 2018-04-16) Avcı, Oǧuzhan; Yapıcı, Orhan; Kasap, Sevim; Temizel, Ethem Mutlu; Karakuş, Adil Ömer; Büyükcangaz, Esra; Kavukçu, Fatih; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; 0000-0002-6834-0808; 0000-0003-4337-577X; AAP-7998-2020; AAL-2323-2020; 26430270100; 57212942021; 36514844800; 25649139400; 57204181576Contagious ecthyma (CE) is a highly contagious viral skin disease that is typically self-limited. Treatment options include topical antiseptics, such as KMNO4, local antibiotics and systemic antibiotics to prevent secondary skin infections. The aim of this study was to compare the effectiveness of the lincomycin/spectinomycin combination and dexpanthenol (Dxp) in goat kids with CE. The study was conducted at a Saanen dairy goat farm in Bursa, Turkey. The owner of the goat herd inquired at the veterinary hospital about the appearance of granulomatous lesions on the muzzles of goat kids. In this study, 24 goat kids (1-month-olds) were used. All animals were subjected to the same conditions. Blood and papule samples were taken from the animals' lips, muzzle and buccal mucosa for virological analysis. Swab samples were taken from the lesions for culture and antibiogram. The animals were divided into three groups. Lesions were clinically scored at days 1, 7 and 15 according to a modified previously used scoring system. Goat kids were equally grouped on the basis of lesions on the buccal mucosa, lips and muzzle. The animals in group A received 15 mg/kg lincomycin/spectinomycin combination (Lypectin*, Vilsan) intramuscularly for 3 consecutive days, group B received 20 mg/kg Dxp (Bepanthen* amp, Bayer, Germany) intramuscularly for 3 consecutive days, and group C received 0.9% NaCl (2 ml), the control treatment. Clinical recoveries were almost equal in all groups, but by day 14, group A showed better recovery than group B and group C. Both study groups also showed better results than the control group for all days. In conclusion, we believe that the lincomycin/spectinomycin combination or dexpanthenol can be useful in the supplementary treatment of CE in goat kids.Publication Comparison of glucose levels in blood samples taken from coccygeal, jugular and mammary vein of cows in lactation(Bursa Uludağ Üniversitesi, 2023-01-23) Akgül, Gülşah; Cihan, Hüseyin; Kasap, Sevim; Evci, Fatma Zehra; Şentürk, Sezgin; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Bölümü; 0000-0003-1544-6438; 0000-0001-9501-9983; 0000-0002-2767-7690; 0000-0002-2465-9913Blood glucose level is one of the most commonly used parameters in assessing the energy metabolism in dairy cows. The presented study aimed to compare the glucose concentrations in blood samples taken from the coccygeal vein, jugular vein, and mammary vein from the sameanimals at the same time. Healthy Holstein-Friesian dairy cows (n=25) in their second and third lactation were selected for the study. Theblood samples were taken from the coccygeal vein, jugular vein, and V. subcutanea abdominis (mammary vein) at the same time from eachanimal. To analyze blood glucose, Free Style Optium Blood Glucose Test Strip (Abbott, Istanbul, TURKIYE) was used. In comparison to theblood taken from both the jugular vein and coccygeal vein, glucose levels in blood samples taken from the mammary vein were significantly low (P<0.001). As a result, the determination of glucose levels in blood samples taken from the mammary veins may cause erroneous interpretations.The refore, the mammary vein for blood glucose must not be used as a sampling site.Item Comparison of serum IgG concentration, total protein, glutaraldehyde coagulation test and gamma glutamyl transferase in neonatal foals(Bursa Uludağ Üniversitesi, 2018-04-15) Kasap, Sevim; Kennerman, Engin; Babaeski, Serdar; Dulger, Hüseyin; Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0001-9501-9983; 0000-0003-3877-2893The purpose of the present study was to detect the passive transfer status in healthy neonatal foals by comparing serum immunoglobulin G (sIgG) concentration, serum total protein (STP), glutaraldehyde coagulation test (GCT) duration and gamma glutamyl transferase (GGT) activity . Fifteen neonatal foals (0-15 days old)’ blood samples were collected before suckling (day 0), 12th hour (hr), 24th hr (1st day), 7th and 15th days. Serum IgG and STP levels significantly increased after the 12th hr. Conversely, serum GCT duration significantly decreased (p< 0.05) in neonatal foals after the 12th hr. The result of the present study was shown that measurements of sIgG, STP concentration and GCT duration are useful parameters to detect Failure of Passive Transfer (FPT) in neonatal foals. While GCT and STP provide a simple and inexpensive field test, serum GGT measurement is not a beneficial test to determine colostrum intake in newborn foals.Item Determination of the effect of a monensin capsule (continuous-release capsules) on metabolic parameters in transition dairy cows(Polish Society Veterinary Sciences, 2020-06-01) Ertürk, Melih; Kasap, Sevim; Mecitoğlu, Zafer; Dülger, Hüseyin; Babaeski, Serdar; Kennerman, Engin; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; 0000-0002-5557-121X; AAH-1677-2021; 36514844800; 36457647300; 55376821600; 57211806818; 16031244000Monensin is an ionophore antibiotic that changes the population of rumen bacteria. The aim of this study was to determine the effects of a monensin controlled-release capsule administered 3 weeks before calving on blood metabolites (serum beta-hydroxybutiric acid (BHBA), cholesterol (CHOL), urea, creatinine (CREA), gamma glutamyl transferase (GGT), aspartate aminotransferase (AST), total protein (TP), phosphorus (P), magnesium (Mg+), calcium (Ca++), glucose (GLU) and plasma non-esterified fatty acids (NEFA) concentration) and milk yield before and after calving. A total of 50 Holstein-Friesian cows were selected from the same flock. Blood samples were taken 3 weeks before the expected calving date and during weeks 1, 2, 4, 6, and 8 after calving. The cows were divided into two groups: a study group (Group M, n = 40) and a control group (Group C, n = 10). Group M received orally a cylindrical device (Kexxtone, ELANCO Animal Health, Guelph, ON, Canada), and group C received no treatment. BHBA and NEFA were lower (P < 0.05) in group M compared with group C in weeks 6 and 8 after calving. GLU was higher (P < 0.05) in group M compared with group C in week 4 after calving. Urea was higher (P < 0.05) in group M compared with group C in week 1 after calving. There was no statistically significant difference (P <0.05) between the two groups in milk yields. Although milk yield was similar in both groups, the changes in the concentrations of BHBA, NEFA, GLU and urea show that a monensin CRC could be used as a glycogenic precursor.Item Effects on negative energy balance of tannin in dairy cattle(Uludağ Üniversitesi, 2015-08-25) Şentürk, Sezgin; Cihan, Hüseyin; Kasap, Sevim; Mecitoğlu, Zafer; Temizel, Mutlu; Uludağ Üniversitesi/Veteriner Fakültesi.Tannins are polyphenolic compounds. Tannins are chemically divided into two main groups as hydrolysable tannins and condensed tannins. Tannins are used in ruminants in order to prevent ruminal tympani and the formation of high methane gas. In the present study, it was aimed to determine the effects of tannin on of negative energy balance metabolism in dairy cattle. Animals, after the physical examination, were divided into 2 groups as study (test group n = 10) and control group (n = 10). Herbal extract (Quebracho Colorado) of tannin (Unitan Saica Inc., Argentina) which is appropriate for animal use, was applied 90 gr per animal daily for 6 weeks (each 3 weeks in pre and postpartum period) to animals in study group. While no any tannin or other additive was given to the animals in control group. Faeces, blood and milk (only after parturition on days 7, 14 and 21) samples were collected from both group on 21st day before parturition, during parturition and 7th, 14th, and 21st day from parturition. Beta hydroxybutyrate (BHB), albumin, calcium, phosphorus, total protein, BUN, GGT, cholesterol and triglycerides from blood samples and milk urea nitrogen (MUN) levels from milk samples were evaluated. Difference between the groups for BUN, MUN, calcium, phosphorus, triglycerides, albumin, total protein and GGT was not detected. However, a decline was detected for BHB levels during parturition, 7th, 14th (not statistically significant) and 21st (statistically significant) days after parturition in the study group compared to the control group. As a result; in animals, as detected lower BHB levels in animals applied tannin in study group compared to the control group, tannin can be used for the protection against negative energy balance.Item Evaluation of serum iron and iron binding capacity in cows with paratuberculosis(George Thieme, 2009) Şentürk, Sezgin; Mecitoğlu, Zafer; Ülgen, Mihriban; Borum, Ebru; Temizel, Ethem Mutlu; Kasap, Sevim; Uludağ Üniversitesi/Veterinerlik Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veterinerlik Fakültesi/Mikrobiyoloji Anabilim Dalı.; 0000-0002-2465-9913; 0000-0002-6307-5179; AAH-5069-2021; AAP-7998-2020; AAG-8117-2021; 56257771200; 36055033100; 56259664500; 36738850800; 26430270100; 36514844800Objective: The purpose of the study was to evaluate the results of routine haematological, serum iron and iron binding capacity analyses in cattle with Mycobacterium avium subsp. paratuberculosis (MAP) infection. Material and methods: Thirty-eight cows were included in the study. An ELISA for MAP, intradermal Johnin test and microscopic examination of the animals faecal smears for acid fast organisms were performed. According to the results 19 cows (4-8 years old) were found positive and 19 cows (4-7 years old) from the same herd were negative and served as control group. In all cows routine haematological values as well as serum iron level and iron binding capacity were evaluated. Results: When compared with control animals, routine haematological values including haematocrit, haemoglobin and erythrocyte counts were significantly (p < 0.05) lower in positive cows. Also serum iron level (p < 0,01) and iron binding capacity (p < 0.01) were significantly lower in positive cows than in the control group. Conclusion: As a result, these parameters can be important for the mechanism of the pathogenesis of paratuberculosis.Item Gastric rupture in a horse(Kafkas Üniversitesi, 2010) Kasap, Sevim; Salcı, Hakan; Kennerman, Engin; Alasonyalılar, Aylin; Yılmaz, Rahşan; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; 0000-0002-0944-2230; T-4623-2019; AAP-7998-2020; ABG-8940-2020; 36514844800; 8680329000; 16031244000; 8529950700; 15057258600Item Iodine intoxication in beef cattle in Turkey - clinical, hematological and biochemical evaluation(Hellenic Veterinary Medical Soc, 2018) Şentürk, Sezgin; Temizel, Ethem Mutlu; Karakuş, Adil Ömer; Kasap, Sevim; Akkaya, Fatma; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-2465-9913; 0000-0001-6536-5594; AAH-5069-2021; F-4850-2017; AAP-7998-2020; 56257771200; 26430270100; 57212942021; 36514844800; 57217582317Iodine is an essential trace element for humans and animals. The incidence of iodine poisoning in cattle is low. In the present study, we evaluated the clinical findings, serum glucose and cholesterol, thyroid hormone and urine iodine levels in cattle exposed to excess iodine. All of the clinical data were determined following the addition of potassium iodide to the drinking water. Inappetence, cough, and hyperthermia were notable clinical findings. We detected a very high iodine level (470 mu g /L) in an analysis of the drinking water samples. A biochemical analysis revealed that the serum cholesterol levels in the affected cattle were significantly lower (p<0.05) than in healthy cattle. However, the serum glucose in the affected cattle was significantly higher (p<0.05) compared to healthy cattle. The iodine concentration in the urine of the affected animals was also significantly higher (p<0.05) than in the healthy animals. Importantly, a hematological analysis indicated leukocytosis with neutrophilia. Several clinical signs, including hyperthermia, tachycardia, alopecia, and a naso-oral discharge, based on suspected history can suggest iodine intoxication. In addition, biochemical parameters, such as urine iodine, serum glucose and cholesterol levels, were observed to be different between healthy and affected cattle. The thyroid function in affected cattle should also be studied.Item Mycoplasma agalactiae ile doğal enfekte bir keçi işletmesinde tylosinin etkilerinin değerlendirilmesi(Uludağ Üniversitesi, 2011-04-05) Önat, Kaan; Temizel, E. Mutlu; Göçmen, Hüban; Mecitoğlu, Zafer; Kasap, Sevim; Ülgen, Mihriban; Uludağ Üniversitesi/Veteriner Fakültesi.; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü.Bu çalışmada, Bursa Yenişehir’de Bulaşıcı Agalaksiya hastalığı semptomları gösteren bir keçi sürüsü bakteriyolojik ve serolojik olarak incelendi ve Tylosin tedavisi sonrasında etken saçılımı değerlendirildi. Bütün hayvanların klinik muayenelerinin yapılmasının ardından serolojik muayeneleri yapıldı. Klinik muayene sonucunda 10 adet keçinin Bulaşıcı Agalaksiya hastalığının semptomlarını gösterdiği tespit edildi. Çalışmalarda 110 keçinin kan serumları ELISA ile incelendi ve klinik bulgu gösteren 10 hayvan dâhil 31 keçide seropozitiflik belirlendi. Bu 10 keçinin beşinde eklem şişlikleri, diğer beşinde ise eklem şişliği olmaksızın topallık gözlendi. Eklemlerinde şişlik bulunan beş keçiden alınan eklem sıvıları bakteriyolojik olarak incelendi ve dördünden Mycoplasma agalactiae izole edildi. Semptom gösteren 10 keçiye 5 gün süre ile 10 mg/kg Tylosin® (Tylan®, Lilly Elanco, Türkiye) uygulaması yapıldı. Laktasyonu takiben bütün keçilere tekrar ELISA testi yapıldı ve 34 keçide seropozitiflik saptandı. Seropozitif keçilerden alınan 34 süt örneğinin 9’undan Mycoplasma agalactiae izole edildi. Tylosin tedavisi uygulanan 10 keçiden sadece birisinde süt ile etken saçıldığı saptandı. Sonuç olarak, Tylosin uygulamalarının M. agalactiae’nın laktasyon sonrasında süt ile saçılımını azaltması ve klinik bulgularının iyileşmesi yönünde olumlu etkilerinin olduğu kanısına varıldı.Item Neonatal ruminantlarda d-laktik asidoz(Bursa Uludağ Üniversitesi, 2018-10-10) Karakuş, Adil Ömer; Kasap, Sevim; Dülger, Hüseyin; Temizel, Ethem Mutlu; Uludağ Üniversitesi/Veteriner Fakültesi.Neonatal ruminantlarda D-laktik asidoz, metabolik asidoza sebep olan ve sıklıkla gözden kaçabilen bir durumdur. D-laktik asidoz ile seyreden hastalıklar hayvan türlerine göre farklı isimlerle adlandırılmıştır. Oğlaklarda hastalık tablosu ‘Floppy Kid Disease’, sığırlarda ‘Ruminal Drinkers’ son olarak kuzularda ‘Drunken Lamb Sendromu’ olarak adlandırılmıştır. Bu üç hastalığın etiyopatogenezinde, rumende veya barsak florasında ani ve çok miktarda bakteriyel fermantasyon sonucu artan D-laktik asit’in sistemik dolaşıma katılması ve anyon açıklı metabolik asidozun oluşumu rol almaktadır. D-laktik asidoz, depresyon, dehidrasyon ve nörolojik belirtilerin oluşmasına yol açabilmekte ve tanısı zor konulmaktadır. Bu derlemede D-laktik asidoz’un metabolizması, patogenezi hayvan türlerine göre oluşan klinik bulguları ve laboratuvar değişimleri irdelenecektirItem Prevalance of behavioral changes associated with age-related cognitive impairment in geriatric dogs, Bursa, Turkey(Medwell Online, 2010-03-15) Yalçın, Ebru; Kasap, Sevim; Demir, Gülşah; Uludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Bilimler Bölümü.; AAP-7998-2020; 36778554000; 36514844800; 36542081400The aim of this study was to investigate the prevalance of behavioral changes associated with age in dogs and their relationship to sex, reproductive status, weight, housing and feeding. About 134 dogs older than 7 years were included in this study. Owners of dogs were interviewed and gather information about signs: sleep/wake cycle, social interaction, learning and house training and disorientation. Forty seven dogs (35.07%) were found to have shown behavioural changes associated with age-related cognitive impairment. Prevalance increased with age. There were no significant effects of sex, weight, housing (inside/outside) and feeding (dry food/home made) on behavioral changes. According to categories, 20 dogs had alterations in one category, 7 dogs had two categories, 12 dogs with three categories and 7 dogs had four categories. The most impaired behavioral categories were changes in sleep/wake cycles (32%) and social interaction (30%) followed by disorientation (20%) and learning and house training (18%). The results of this study suggest that estimates of the prevalance of various degrees of age-related behavioral changes. Veterinarian and dog owner should be aware of this problem.Item Prevalence of ketosis in dairy herds in Marmara, Aegean and Mediterranean regions of Turkey(Ankara Üniversitesi, 2015-10-12) Şentürk, Sezgin; Cihan, Hüseyin; Mecitoğlu, Zafer; Çatık, Serkan; Akgül, Gülşah Demir; Kasap, Sevim; Topal, Onur; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; 0000-0002-5557-121X; 0000-0002-2465-9913; 0000-0002-1933-7354; AAH-1677-2021; AAH-5069-2021; AAP-7998-2020; ABH-3742-2020; S-8278-2017; 56257771200; 6602381681; 36457647300; 56515323800; 57189238457; 36514844800; 56548777100Increasing energy demands of high-yielding dairy cow in postpartum period results almost always with negative energy balance (NEB). According to the degree of NEB, dairy cows could suffer from clinical or subclinical ketosis. The aim of the presented study was to evaluate the incidence and difference between incidences of clinical and subclinical ketosis in three regions with highest cattle population in Turkey; Marmara, Aegean and Mediterranean regions. Cattle (n = 980) from three regions (2 farms from each region) were selected for the study. Milk yields, management and feeding factors of all farms were similar. Blood samples were collected on days 14-21 and sixth week after calving. Blood beta hydroxybutyric acid (BHBA) and glucose levels were measured. Cows with serum BHBA > 1.2 mmol/l and negative urine ketone test were designated as suffering subclinical ketosis (SCK). Cows with serum BHBA > 1.2 mmol/l, positive urine test and clinical findings such as anorexia, fatigue, depression, constipation and decrease in contractions of rumen were designated as suffering clinical ketosis (CK). Animals without any clinical finding and serum BHBA levels lower than 1.2 mmol/l at the time of sampling were designated as healthy. In Mediterranian region, 12 (3,8%) and 46 (14,8%) of 315; in Aegean region, 24 (7,3%) and 54 (16,6%) of 325, and in Maramara region, 33 (9,7%) and 76 (22,3%) of 340 cows were suffered from CK and SCK respectively in postpartum period. Blood glucose levels of CK cows was lower than SCK cows and blood glucose levels of both types of ketosis were lower than healthy animals in animals from all three regions. The results of the presented study indicate that incidence of CK and SCK is much higher than average incidence rates in other surveys. Especially incidence higher than 20% in Marmara region demonstrates that there are crucial errors in management and feeding in that region.Item Results of cytological and microbiological examination using tracheal aspiration in race horses with lower respiratory tract disease(Veterinarni A Farmaceuticka Univerzita Brno, 2018-12-07) Göçmen, Huban; Kasap, Sevim; Kennerman, Engin; Cihan, Hüseyin; Ülgen, Mihriban; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; 0000-0003-1544-6438; 0000-0002-6307-5179; AAP-7998-2020; ABH-3742-2020; AAG-8117-2021; 36514844800; 16031244000; 6602381681; 56259664500Respiratory tract disease is the second most common cause of poor performance in racehorses after musculoskeletal disease. Lower respiratory tract disorders (LRTD) are common in thoroughbred horses of all ages. The aim of this study was to investigate whether there was any association between the microbiological and cytological examinations. Fifty horses ranging in age from 2 to 6 years were examined. Horses with only upper respiratory tract abnormalities identified by endoscopy (at rest) were eliminated from the study and horses with LRTD were used in this study. Tracheal aspirate specimens were collected for cytological and microbiological examinations. Thirty six horses had positive and 14 horses had negative cultivation. The isolated bacteria included 13-haemolytic Streptococcus equi subsp. zooepidemicus (38.8%), Escherichia coli (22.2%) and other bacteria that were isolated at rates ranging from 0.4 to 1.8%. Percentages of neutrophils, lymphocytes, eosinophils, macrophages and mast cells were evaluated in the cytological examination. The percentages of neutrophils were significantly higher in the samples with isolated bacteria (35.75 +/- 2.60%) compared to the samples from which bacteria were not isolated (16.79 +/- 2.36%) (P < 0.001). This study shows that S. equi subsp. zooepidemicus could play an important role in the etiopathogenesis of LRTD. It also demonstrates the importance of evaluating the microbiological findings of the tracheal aspirate specimens from horses suffering from respiratory infections, in addition to performing a detailed clinical examination and other complementary tests that focus on the respiratory system, such as endoscopy and cytology of the tracheal aspiration.