Browsing by Author "Harrison, William T. A."
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Item New palladium(II) and platinum(ii) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2′-bipyridine and 2,2′-dipyridylamine: Synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity(Royal Soc Chemistry, 2015) Harrison, William T. A.; Büyükgüngör, Orhan; İçsel, Ceyda; Yılmaz, Veysel Turan; Kaya, Yunus; Şamlı, Hale; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.; Uludağ Üniversitesi/Veteriner Fakültesi/Genetik Anabilim Dalı.; 0000-0002-2849-3332; 0000-0002-2717-2430; AAH-6488-2021; L-7238-2018; AAI-3342-2021; 55551960400; 7006269202; 35181446100; 6507670789Novel palladium(II) and platinum(II) complexes of 5,5-diethylbarbiturate (barb) with 2-phenylpyridine (Hppy), 2,2'-bipyridine (bpy) and 2,2'-dipyridylamine (dpya) have been prepared and characterized by elemental analysis, IR, UV-Vis, NMR and ESI-MS. Single-crystal diffraction measurements show that complex 1 consists of binuclear [Pd-2(mu-barb-kappa N,O)(2)(ppy-kappa N,C)(2)] moieties, while complexes 3-5 are mononuclear, [M(barb-.kappa)(2)(L-kappa N,N')] (L = bpy or dpya). 6 has a composition of [Pt(dpya-kappa N,N')(2)][Ag(barb-kappa N)(2)](2)center dot 4H(2)O and 2 was assumed to have a structure of [Pt(barb-kappa N)(Hppy-kappa N)(ppy-kappa N,C)]center dot 3H(2)O. The complexes were found to exhibit significant DNA binding affinity by a non-covalent binding mode, in accordance with molecular docking studies. In addition, complexes 1 and 2 displayed strong binding with supercoiled pUC19 plasmid DNA. Cellular uptake studies were performed to assess the subcellular localization of the selected complexes. A moderate radical scavenging activity of 1 and 2 was confirmed by DPPH and ABTS tests. Complexes 1, 2, and 5 showed selectivity against HT-29 (colon) cell line.Item Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies(Elsevier France, 2013-02) Harrison, William T. A.; İçsel, Ceyda; Yılmaz, Veysel T.; Arı, Ferda; Ulukaya, Engin; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; 0000-0002-6729-7908; 0000-0002-2849-3332; 0000-0002-2717-2430; AAG-7012-2021; L-7238-2018; K-5792-2018; AAI-3342-2021; 55551960400; 7006269202; 24376085300; 6602927353Four trans-palladium(II)- and trans-platinum(II)-chlorido complexes, trans-[PdCl2(2-hmpy)(2)] (1), trans-[PtCl2(2-hmpy)(2)] (2), trans-[Pdcl(2)(2-hepy)(2)] (3) and trans-[PtCl2(2-hepy)(2)] (4) (2-hmpy = 2-(hydroxymethyl)pyridine and 2-hepy = 2-(2-hydroxyethyl)pyridine), have been synthesized and characterized by elemental analysis, IR, NMR, and X-ray diffraction. The binding properties of these complexes with fish sperm DNA (FS-DNA) were investigated by UV titration, viscosity, thermal denaturation and electrophoresis measurements. The complexes can bind to FS-DNA and complex 4 exhibits the highest binding constant. Gel electrophoresis assay demonstrates that all the complexes can cleave the pCMV-beta gal plasmid DNA to a different degree. The cytotoxic activities of the complexes were tested against four different cancer cell lines. In general, the platinum(II) complexes are more effective than the isostructural palladium(II) complexes. Complex 4 shows high anticancer activity, compared to transplatin, cisplatin, carboplatin and oxaliplatin.