Browsing by Author "Gebitekin, Cengiz"
Now showing 1 - 20 of 58
- Results Per Page
- Sort Options
Item Adenosquamous carcinoma of the lung: Comparison of surgical outcomes with squamous cell and adenocarcinoma(Elsevier, 2018-10) Melek, Hüseyin; Çetinkaya, G.; Bayram, Ahmet Sami; Akyıldız, Elif Ülker; Yenitürk, Eylem; Özer, Erhan; Sevinç, Tayhan; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-1822-8153; 0000-0003-0684-0900; 0000-0002-4848-1566; AAI-5039-2021; AAE-1069-2022; ABB-7580-2020; JCE-0097-2023; JDW-2654-2023Item Akciğer rezeksiyonları sonrası komplikasyon tahmininde maksimal oksijen tüketim testinin önemi(Uludağ Üniversitesi, 2001) Candan, Tarık; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Kalp ve Damar Cerrahisi Anabilim Dalı.Akciğer rezeksiyonu yapılan hastalarda ameliyat sonrası dönemde gelişen komplikasyonlar alınan tüm tedbirlere rağmen halen önemli sorun olmaya devam etmektedir. Bu komplikasyonları ameliyat öncesi tahminde en yararlı testin hangisi olduğu konusunda görüş birliği yoktur. Bu çalışmada majör akciğer rezeksiyonu planlanan hastlarda "maksimal egzersiz oksijen tüketim kapasitesi" nin postoperatif mortalite ve morbiditeyi tahmindeki önemini ortaya koymayı ve "standart solunum fonksiyon testi" ile bu alandaki rollerini karşılaştırmayı amaçladık. Çalışmaya majör akciğer rezeksiyonu öncesi "solunum fonksiyon testi" ve "maksimal egzersiz oksijen tüketim testi" yapılan hastalar dahil edildi. Hastaların postoperatif hastanede kalış süreleri, mortalite ve morbidite oranları incelendi. Akciğer rezeksiyonu öncesi her iki testin uygulandığı 49 u erkek (%89), 6 sı kadın(%11) toplam 55 hasta çalışmaya dahil edildi. Hastalar egzersiz testi sonuçlarına göre VC>2max değerleri 15 ml/kg/dak' nın altında (V₁) ve üstünde (V₂); SFT ile yapılan değerlendirmeye göre FEV₁ değeri 2 litrenin altında (S₁) ve üstünde (S₂) olmak üzere dört gruba ayrıldı. Ortalama yaş 56 olarak bulundu (20-74 yaş arası). Toplam 19 hastada (%34,5) morbidite gelişti. V₁ grubunda genel morbidite oranı %42 olurken, V₂ grubunda %25 olarak gerçekleşti. Pulmoner komplikasyon (pnömoni, atalektazi ve ampiyem ) gelişen 11 hastanın tamamı V₁ grubunda (%39,2) yer aldı (P>0,05 ). SFT'ye göre yapılan değerlendirmede ise gruplar arasında pulmoner komplikasyon açısından istatistiksel anlamlı farklılık bulunmadı. Toplam 2 (%3,6) hastada mortalite gelişti. Mortalite gelişen iki hasta da V₁ grubunda yer alıyordu (%7,1). Solunum fonksiyon testi'ne göre yapılan sınıflamada ise mortalite gelişen hastalardan biri S₁ grubunda diğeri ise S₂ grubunda yer aldı. Egzersiz V0₂max değeri 20 ml/kg/dak dan fazla olan hastaların hiçbirinde mortalite veya morbidite gelişmedi. Oksijen tüketim kapasitesinin ölçümü majör akciğer rezeksiyonu sonrası gelişebilecek komplikasyoniarın tahmininde ve mortalite riski yüksek hastaların seçilmesinde yenj ve güvenilir bir testtir.Item Arterial lesions in Behcet's disease(Verlag Hans Huber, 2003-05) Saba, Davit; Sarıcaoğlu, Hayriye; Bayram, Ahmet Sami; Erdoğan, Cüneyt; Dilek, Kamil; Gebitekin, Cengiz; Özkan, Hayati; Özer, Z. Gökalp; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; ABB-7580-2020; 55987378200; 6603722836; 8347194000; 8293835700; 56005080200; 6602156436; 7103355993; 6701509634Background: Arterial involvement is a rare but serious condition in the course of Behcet's disease. We aimed to assess the results of therapeutic approaches in our patients with arterial lesions caused by Behcet's disease. Patients and methods: The records of 534 patients with Behcet's disease between 1987 and 2002 were retrospectively evaluated for the presence of arterial lesions. All patients were followed up regularly, at 3 to 6 months intervals. Results: Arterial lesions were diagnosed in 21 (3.9%) patients. Eight of these patients had pulmonary artery aneurysms (PAA), and the other 13 patients had non-pulmonary arterial lesions. Urgent surgical intervention was performed in three patients with PAA leading to death in all three. In addition, three other patients died due to massive haemoptysis at home despite to immunosuppressive therapy. Only two out of eight patients with PAA are still alive who were treated with cyclophophamide and corticosteroids. Thirteen operations were performed in 7 out of 13 patients having non-puhnonary arterial lesions. Although ten of the operations were primary operations, three reoperations had to be performed. A stent-graft was applied for the management of an iliac artery aneurysm in one patient. Only one patient died 8 years after the first non-pulmonary arterial involvement following a type IV thoracoabdominal aortic aneurysm repair Five patients with arterial occlusive lesions were successfully treated by corticosteroids. Conclusions: Pulmonary artery aneurysms in Behcet's disease patients have a poor prognosis despite any form of therapy. High dose corticosteroids alone can be successfully used for isolated non-pulmonary arterial occlusive lesions, unless disabling symptoms occur. Surgery or stent-graft insertion is indicated,for non-pulmonary arterial aneurysms because these aneurysms entail high risk of complications.Item Assessment of molecular events in squamous and non-squamous cell lung carcinoma(Elsevier Ireland, 2006) Schulten, Hans-Jürgen; Demir, Adalet; Frank, Derk; Danner, Bernd; Kahler, Elke; Gunawan, Bastian; Ürer, Nur; Fuezesi, Laszlo; Yakut, Tahsin; Egeli, Ünal; Gebitekin, Cengiz; Öztürk, Hülya; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0001-7904-883X; AAH-1420-2021Although considerable knowledge exists on the tumor biology of lung cancer, there is still a need to assess molecular events for the clinical management of the disease. We studied the pattern of chromosomal imbalances in 45 non-small cell Lung carcinomas (NSCLC) by comparative genomic hybridization (CGH) and correlated the results with clinicopathological features including immunohistochemical (IHC) expression of the epidermal. growth factor receptor (EGFR). Twenty-one tumors were squamous cell carcinomas (SCC) and 24 non-squamous cell lung carcinomas (NSCC) comprising 9 adenocarcinomas (ADC), 9 large cell carcinomas (LCC), 4 sarcomatoid carcinomas and 2 adenosquamous carcinomas. The mean number of individual imbalances was 7.1 for SCC (mean gains, 3.8; mean tosses, 3.4) and 6.4 for NSCC (mean gains, 4.5; mean tosses, 1.9). Several individual imbalances correlated significantly with increasing number of imbalances, that were +1q, -3p, +3q, -5q, -8p, +8q, +7p, +12p, and +14q. Altogether, the most frequent imbalances were +3q (49%), +5p (49%), -5q (36%), +8q (29%), -8p (24%), -3p (22%), +7p (22%), +12p (22%), +14q (20%), +18p (20%), +1q (18%), and +7q (18%). Among these, +3q and +18p correlated significantly with SCC, and +5p and +14q with NSCC. Remarkably, overlapping imbalances included +3q26, +7p11 in SCC and +1q21, +3q24, +12p11, and +14q12 in NSCC. EGFR expression was higher in SCC than in NSCC and correlated with +3q in the entire series. In addition, +12p correlated significantly with disease progress with the exception of nodal involvement in NSCC as well as with disease progress, regardless of nodal involvement, in the entire series. In conclusion, the present study contributes to the molecular biological characterization of NSCLC histological subtypes and through evaluation of molecular events to the recently emergent focus on novel markers for lung cancer treatment.Item Basic interrupted versus continuous suturing techniques in bronchial anastomosis following sleeve lobectorny in dogs(Oxford University Press, 2007-09-03) Erol, Mehmet Muharrem; Bayram, Ahmet Sami; Salcı, Hakan; Özyiǧit, Özgür M.; Görgül, Sacit O.; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; 0000-0003-0684-0900; 8347194000; 8680329000; 22954215300; 22953784900; 6602156436Objective: Sleeve resection with or without lung resection is a valid conservative operation for patients with benign or malignant tumors; it enables the preservation of lung parenchyma. The aim of this prospective randomized study was to compare complications, operating time, and bronchial heating between the techniques of interrupted and continuous suturing for bronchial anastomosis in dogs. Methods: Twenty adult mongrel dogs each weighing 18-22 kg (average: 20 kg) were divided into two groups according to the anastomosis technique performed: group A, interrupted suturing and group B, continuous suturing. Each group comprised of 10 dogs. Following right thoracotomy, sleeve resection of the right cranial lobe was performed in all dogs. Basic interrupted sutures using 4/0Vicryl (Ethicon, USA)were used in group A, and continuous sutures were used in group B. Results: The median anastomosis time was 15.2 min (range: 13-21 min) in group A and 9.6 min (range: 8-13 min) in group B. In all dogs, the anastomosis line was resected via right pneumonectomy for histopathological investigation 1 month after sleeve resection. Histopathological examination revealed that the healing of the anastomosis was not affected by the suturing technique applied. One dog from each group died on the fourth postoperative day; Fisher's exact test, p = 0.763. Conclusions: Our research revealed that the heating of the anastomosis was not affected by the suturing technique performed.Item Bronş kanserli hastalarda evrelendirme amaclı yapılan mediastinoskopide lenf nodu biopsisinin ince iğne aspirasyon biopsisi ile karşılaştırılması(Uludağ Üniversitesi, 2004) Dülger, Hüseyin; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.Akciğer kanserinin malignite potansiyelinin yüksek oluşu, anatomik ve fizyolojik özellikleri nedeniyle çok kısa sürede ölüme neden olabilmektedir. Bu özelliğine rağmen akciğer kanserinde en başarılı ya da en uzun yaşam cerrahi tedavi uygulanan erken evre olgularda görülmektedir. Mediastinoskopi, rezeksiyon planlanan akciğer kanseri hastalarında, ameliyat öncesinde tümörün evresini tespit etmek ve hastalığın prognozunu öğrenmek açısından önem taşır. Mediastinal lenf bezi metastazı bulunan (N2) Evre IIIA Küçük Hücre Dışı Akciğer Kanseri (KHDAK) hastalarında tam cerrahi rezeksiyon mümkün görünse de 5 yıllık sağkalım oranları %10'un üzerine çıkamamaktadır. Fakat, N2 tespit edilen hastalarda uygulanan neoadjuvan tedavi sonrasında yapılan rezeksiyonlar, sadece cerrahi tedavi uygulanan hastalardan daha iyi sonuçlar vermektedir. Bu çalışmadaki amaç, mediastinal lenf nodu metastaz şüphesi olan bronş kanserli hastalarda preoperatif dönemde uygulanan mediastinoskopide biopsi ile ince iğne aspirasyon biopsisi sonuçlarının karşılaştırılmasıdır. Kasım 2003 - Mayıs 2004 tarihleri arasında Uludağ Üniversitesi Tıp Fakültesi Hastanesi Göğüs Cerrahisi Ana Bilim Dalı'nda toraks bilgisayarlı tomografisinde 1cm.' den daha büyük mediastinal lenf bezi bulunan bronş kanserli hastalarda evrelendirme amaçlı yapılan mediastinoskopide, mediastinal lenf nodu biopsisinin ince iğne aspirasyon biopsisi (IIAB) ile karşılaştırılması amacıyla 25 akciğer kanserli hasta çalışmaya dahil edildi. Standart servikal mediastinoskopi tekniği ile alınan aynı lenf bezine ait doku biopsisi ve ince iğne aspirasyon biopsisi histopatolojik, sitolojik inceleme için patoloji bölümüne gönderildi. Patolojide hazırlanan biopsi örnekleri Hematoxilene-Eosin (HE) ile boyandı, lam üzerine yayılan ince iğne aspirasyon biopsileri patoloji laboratuarına ulaştıktan sonra % 50'si Giemsa, % 50'si HE ile boyama işlemini takiben değerlendirildi. Çalışmaya alınan 25 hastanın 24'ü erkek (%96), 1'i kadın (%4)'dı ve yaş ortalaması 56,4 ±9,1 yıl (33-78) idi. Lenf nodu biopsisi uygulanan 25 hastanın, 13 (%52)'ünde benign reaktif hiperplazi, 12 (%48)'sinde ise mediastinal lenf nodu metastazı tespit edildi. Her iki yöntem karşılaştırıldığında 25 hastanın 21 (%84)'inde paralel sonuç elde edilirken IIAB ile 4 hastada ek tanı elde edilmiştir. İnce iğne aspirasyonu sonrası HE ve Giemsa boyaması ile sitolojik inceleme yapılan ve biopsi sonuçları benign olarak değerlendirilen dört hastada yassı epitei hücreli karsinom metastazı tanısı konuldu. Sonuç olarak; ince iğne aspirasyon biopsisi klasik doku biopsisi ile tanı konulamayan 4 hastada evrelemeye yardımcı olmuştur. Yöntemin gerçek üstünlüğünün ispatı iyin daha büyük çalışmalara ihtiyaç vardır.Item Bronş kanserli hastalarda mediastinal lenf bezi tutulumunun "p53 gen mutasyonu yöntemi" ve "histopatolojik yöntem" ile karşılaştırılması(Uludağ Üniversitesi, 2002) Bayram, Ahmet Sami; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Kalp ve Damar Cerrahisi Anabilim Dalı.Küçük Hücre Dışı Akciğer Kanseri (KHDAK)'nde tedavi metodunu ve prognozu belirleyen en önemli faktör hastalığın evresidir. Erken evre tümörlerde (Evre la ve Ib) yapılan küratif rezeksiyona rağmen 5-yıllık yaşam beklentisi hiçbir zaman mükemmel rakamlara (%55-85) ulaşamamıştır. Bölgesel lenf bezi metastazı bulunmayan "NO" olgularda lokal nüks ve/veya uzak metastazlara rastlanması ve beklenenden daha az 5-yıllık yaşam değerleri elde edilmesi patolojik "NO" evresinin sorgulanmasını gerektirmiştir. Günümüzde; mediastinoskopi ile mediastinal lenf bezi metastazı bulunan "N2" olgularda en ideal yaklaşım neo-adjuvant kemoterapi sonrası cerrahi rezeksiyondur. Bu çalışmadaki amaç mediastinoskopi sonrası histopatolojik "NO" değerlendirilen lenf bezlerindeki p53 genindeki mutasyon pozitifliğinin değerlendirilmesi ile gerçek "NO" evrelenmesinin karşılaştırılmasıdır. Ocak 2001-Ocak 2002 tarihleri arasında primer KHDAK'nin preoperatif evrelendirilmesinde toraks bilgisayarlı tomografisinde 1cm.' den daha küçük mediastinal lenf bezi bulunan ve servikal mediastinoskopi uygulanan olgulardan 30'u çalışmaya dahil edildi. Standart servikal mediastinoskopi tekniği ile alınan aynı lenf bezine ait biyopsi materyali taze olarak eşit iki parçaya ayrıldı. Biopsi materyali histopatolojik ve genetik inceleme için gerekli bölümlere gönderildi. Patolojide hazırlanan biopsi örnekleri Hematoxilene-Eosin (HE) ile boyandı diğer örnek ise Polimeraz Zincir Reaksiyonu (PZR) yöntemi ile p53 gen mutasyonu tespiti için hazırlandı. Çalışmaya alınan 30 olgunun 29'u (%97) erkek ve yaş ortalaması 61.2 (42-74) idi. Olguların tamamından alınan lenf bezlerinin histopatolojik incelemesi sonucunda metastaza rastlanmadı. Fakat bu olgulardan 6(%20),sının lenf bezlerinin PZR yöntemi ile moleküler biyolojik incelemesi sonucunda p53 gen mutasyonu tespit edildi (Genetik Metastaz). Sonuç olarak; histopatolojik inceleme sonrası "NO" olarak bildirilen fakat p53 mutasyonu bulunan olgularda lokal nüks ve/veya uzak metastaz dikkatli takip edilmelidir. Bu hastalarda histopatolojik negatifliğe rağmen neo-adjuvan veya adjuvan tedavi rejimlerinin uygulanması gündeme gelmelidir.Item Case of solitary eosinophilic granuloma of the sternum(Georg Thieme, 2008-03) Bayram, Ahmet Sami; Köprücüoǧlu, Mustafa; Filiz, Çaǧla; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; ABB-7580-2020; AAE-1069-2022; 8347194000; 23987533500; 23987838700; 6602156436We report a rare case of eosinophilic granuloma of the sternum in a 13-year-old male patient, who presented with anterior chest pain and a tender mass over the sternum.Item Chest wall tumors, non pancoast(Elsevier, 2011-06) Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Bilimler Anabilim Dalı.; AAE-1069-2022Item Clinical outcomes of lung metastasectomy in patients with colorectal cancer(Baishideng Publishing Group, 2012-02-21) Ölmez, Ömer Fatih; Çubukçu, Erdem; Bayram, Ahmet Sami; Akçalı, Ünsal; Evrensel, Türkkan; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-9732-5340; AAJ-1027-2021; ABB-7580-2020; 26435400000; 53986153800; 8347194000; 16027743900; 6603942124; 6602156436AIM: To investigate prognostic factors of survival following curative, non-palliative surgical removal of lung metastases secondary to colorectal cancer (CRC). METHODS: Between 1999 and 2009, a radical metastasectomy with curative intent was performed on lung metastases in 21 patients with CRC (15 male and 6 female; mean age: 57.4 +/- 11.8 years; age range: 29-74 years) who had already undergone primary tumour resection. RESULTS: The mean number of lung metastases ranged from one to five. The mean overall survival was 71 +/- 35 mo (median: 25 mo). After adjusting for potential confounders, multivariable Cox regression analyses predicted only the number of lung metastases (1 vs >= 2; hazard ratio: 7.60, 95% confidence interval: 1.18-17.2, P = 0.03) as an independent predictor of poor survival following lung resection for metastatic CRC. CONCLUSION: Resection of lung metastases is a safe and effective treatment in selected CRC patients with single lung metastases. (C) 2012 Baishideng. All rights reserved.Item Combination of tissue biopsy and fine needle aspiration cytology reduces false negativity of mediastinoscopy for non-small cell lung cancer(Bayçınar Medical-Bayçınar Tıbbi Yayıncılık, 2012-04) Erol, Mehmet Muharrem; Bayram, Ahmet Sami; Dülger, Hüseyin; Balaban, Şaduman Adım; Aygün, Mert; Yerci, Ömer; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; ABB-7580-2020; 8347194000; 57225229141; 7003295230; 23666403500; 6603810549; 6602156436Background: This study aims to compare tissue biopsy with fine needle aspiration (FNA) and investigate whether the combination reduces false negativity of mediastinoscopy. Methods: Between January 2004 and October 2005, 92 patients with non-small cell lung cancer (NSCLC) who underwent cervical video mediastinoscopy were included in this prospective study. Tissue biopsy samples and FNAs were obtained from the same lymph node and were sent for a pathologic examination. Tissue samples and FNAs were stained with Hematoxilene-Eosine. All specimens were evaluated by two histopathologists. Results: Using tissue biopsy samples, no metastasis was found in 54 patients, while 38 patients were metastatic. Forty-eight patients had no metastasis, while 44 patients were metastatic using FNA samples. The difference was statistically non-significant (p>0.05). The false negativity of the FNA and tissue biopsy were 5.4% and 12%, respectively. Subsequently, 43 patients with negative FNA and tissue biopsy underwent lung resection with thoracotomy and sistematic lymph node dissection. Following lymph node dissection, lymph node metastases were found in two cases (4.6%). As a result, false negativity of mediastinoscopy was reduced to 4.6% when two techniques were combined. There was no complication related to the technique. Conclusion: The FNA of mediastinal lymph nodes is a safe and effective method, compared to tissue biopsy and reduces the false negativity of mediastinoscopy when combined with tissue biopsy.Item Comparison of different bronchial closure techniques following pneumonectomy in dogs(Korean Soc Veterinary Science, 2007-12) Salcı, Hakan; Bayram, Ahmet Sami; Özyiğit, Özgür M.; Gebitekin, Cengiz; Görgül, Osman Sacit; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-0684-0900; AAE-1069-2022; ABB-7580-2020; T-4623-2019; 8680329000; 8347194000; 22954215300; 6602156436; 6507730974The comparison of the histologic healing and bronchopleural fistula (BPF) complications encountered with three different BS closure techniques (manual suture, stapler, and manual suture plus tissue flab) after pneumonectomy in dogs was investigated for a one-month period. The dogs were separated into two groups: group I (GI) (n = 9) and group II (GII) (n = 9). Right and left pneumonectomies were performed on the animals in GI and GII, respectively. Each group was further divided into three subgroups according to BS closure technique: subgroup I (SGI) (n = 3), manual suture; subgroup II (SGII) (n = 3), stapler; and subgroup III (SGIII) (n = 3), manual suture plus tissue flab. The dogs were sacrificed after one month of observation, and the bronchial stumps were removed for histological examination. The complications observed during a one-month period following pneumonectomy in nine dogs (n = 9) were: BPF (n = 5), peri-operative cardiac arrest (n = 1), post-operative respiratory arrest (n = 1), post-operative cardiac failure (n = 1) and cardio-pulmonary failure (n = 1). Histological healing was classified as complete or incomplete healing. Histological healing and BPF complications in the subgroups were analyzed statistically. There was no significant difference in histological healing between SGI and SGIII (p = 1.00; p > 0.05), nor between SGII and SGIII (p = 1.00; p > 0.05). Similarly, no significant difference was observed between the subgroups in terms of BPF (p = 0.945; p > 0.05). The results of the statistical analysis indicated that manual suture, stapler or manual suture plus tissue flab could be alternative methods for BS closure following pneumonectomy in dogs.Publication Comparison of survival results of patients with t0 and t1-2-3 in pathological t staging in patients with non-small cell lung cancer who underwent surgery after neoadjuvant treatment(Termedia Publishing House, 2020-01-01) Kermenli, Tayfun; Melek, Hüseyin; Bayram, Ahmet Sami; Gebitekin, Cengiz; MELEK, HÜSEYİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0684-0900; 0000-0003-1822-8153; AAE-1069-2022; AAI-5039-2021; JCE-0097-2023; ABB-7580-2020Aim: In this study, we aimed to compare the survival results of patients who underwent neoadjuvant treatment with NSCLC between March 1997 and August 2014 and were found to have T0N0 and T1-2-3/N0.Material and methods: A hundred ninety-five patients who had complete neoadjuvant therapy, complete lung resection and lymph node dissection, and pathologically diagnosed as T0 or T1-2-3/N0, M0 were included in the study.Results: Of the 195 patients included in the study, 181 were male, 14 were female and the mean age of the patients was 57.9. The mean age of the groups was as follows: group 1: 58.1, group 2: 57.7, group 3: 59.7 and group 4: 56.8. In our series the most common complication was atelectasis (n = 19). Others were prolonged air leak (n = 16), pneumonia (n = 12), apical pleural space (n = 6), wound infection (n = 3), cardiac problems (n = 3), hematoma (n = 3), bronchopleural fistula (n = 3), empyema (n = 2), chylothorax (n = 1). The 5-year survival rate for patients in the T0N0 group was 76.3%. This rate was 71.8% in group 2, 63.6% in group 3 and 44.1% in group 4.Conclusions: Survival was found to be better in patients who underwent surgery after neoadjuvant therapy and had a complete pathological response. We believe that we can provide better results with the increase in the number of cases detected as TxN0 after the neoadjuvant treatment and prolongation of the follow-up period.Item Comparison of two suturing techniques in tracheobronchial anastomosis following the wedge carinal resection in dogs(Kafkas Üniversitesi, 2011) Erol, Mehmet Muharrem; Salcı, Hakan; Bayram, Ahmet Sami; Özyiğit, Musa Özgür; Görgül, O. Sacit; Gebitekin, Cengiz; Uludağ Üniversitesi/Veterinerlik Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veterinerlik Fakültesi/Patoloji Anabilim Dalı.; 8680329000; 53264883600; 53264680300; 53264877700; 6602156436Tracheobronchial resection in humans is a still problem in lung cancer invading the carina, because there is not a standard surgical procedure. This study aimed to compare postoperative complications and histopathological results of simple continuous and simple interrupted suturing techniques in tracheobronchial anastomosis following the wedge carinal resection in dogs. Twelve mongrel dogs were divided into A and B groups. Right pneumonectomy with wedge carinal resection technique was performed under general anesthesia, and then tracheobronchial resection line was sutured simple continuously in group A and simple interruptedly in group B. The dogs were checked during two months in terms of postoperative complications, and euthanized at the end of two months to evaluate tracheobronchial anastomosis lines histopathologically. No postoperative complication was encountered in group A; but, 2 dogs in group B died due to respiratory failure on postoperative 4(th) and 12(th) days. Autopsy of the dogs revealed tracheobronchial dehiscence and opening of the simple interrupted suturing line, which was considered operative technique failure of suturing. Histopathologically, the sections taken from tracheobronchial anastomosis line had similar microscopic results in both group. Statistically, Fisher's exact test was applied between groups to determine the differences with regard to postoperative complications and histopathological results. There was no statistically significant differences between the groups in postoperative complications and histopathological results. In conclusion, operative technique failure of suturing is still common in tracheobronchial anastomosis; however, taking the histopathological results of the study into consideration, it has been implied that both suturing technique can be performed in tracheobronchial anastomosis following the wedge carinal resection.Item Complex pulmonary aspergilloma treated with single stage cavernostomy and myoplasty(Oxford Univ Press, 2005-05) Gebitekin, Cengiz; Bayram, Ahmet; Akın, Selçuk; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Plastik Cerrahi Anabilim Dalı.; ABB-7580-2020; 6602156436; 8347194000; 7005263372Objective: Complex pulmonary aspergilloma (CPA) following pulmonary tuberculosis may lead to massive and fatal hemoptysis. Pulmonary resection, as initial therapy, carries high morbidity and mortality. Resection is contraindicated in patients with compromised lung function (FEV1<40%) and in those with bilateral disease. We reviewed the results of patients undergoing single stage cavernostomy and myoplasty as an alternative therapy in patients with normal and compromised lung function. Methods: Patients suffering from recurrent massive hemoptysis (600 ml/24 h or > 150 ml/h) due to CPA were selected for single stage cavernostomy and myoplasty. We performed rib resection, cavernostomy, closure of the bronchial openings and total/partial obliteration of the cavity with a muscle flap as a single stage technique in patients with CPA regardless of pulmonary function or bilateral disease. Patients began oral Itracanozole two weeks prior to surgery and continued for 3 months post-operatively. Results: Three women and four men (median age 38 years;range 24-59 years) with CPA were evaluated. Four patients had either bilateral disease or compromised lung function. Pectoralis major muscle was used for the myoptasty in five and trapezius or latissimus dorsi in the other two patients. The median number of bronchial fistulae closed during the surgery was six (range 2-12). Blood toss was minimal (median 227 ml). Two patients underwent successful re-exploration for significant air teak. The median hospital stay was 9 days (6-27days). Six patients are alive and hemoptysis free (median follow-up 57.2 months). Conclusions: Cavernostomy and myoplasty as a single stage technique is safe and reliable in the management of patients with complex pulmonary aspergilloma. Morbidity is tow even in patients with compromised lung function or bilateral disease.Item Descending necrotizing mediastinitis: Increased mortality due to delayed presentation(TÜBİTAK, 2012-12) Ural, Ahmet; Tekinbaş, Celal; Erol, Mehmet Muharrem; Melek, Hüseyin; Bayram, Ahmet Sami; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0003-1822-8153; AAI-5039-2021; ABB-7580-2020; 35605916500; 9639938400; 8347194000; 6602156436Aim: To describe the clinical features of descending necrotizing mediastinitis (DNM) and to outline the diagnostic and therapeutic measures to be taken in its management. Materials and methods: We retrospectively analyzed the data from 13 patients with DNM treated between 2001 and 2012 in 2 tertiary care centers, together with their demographics, diagnostic methods, therapeutic interventions, and clinical outcomes. Results: The patients consisted of 10 males and 3 females, aged from 16 to 72 years (mean age: 44). Odontogenic and tonsillar infections were the probable sources of infection in the majority of cases. Computerized tomography is a crucial imaging modality in the diagnosis and follow-up of patients with DNM. All patients underwent surgical treatment in addition to intravenous broad-spectrum antibiotics. Tube thoracostomy, mediastinal drainage, cervical drainage, and thoracotomy were the therapeutic measures utilized in these patients. Five patients were lost (38%) and 8 survived. Conclusion: DNM is a life-threatening condition that may originate from oropharyngeal infections. Emergency surgical intervention is mandatory in the management of DNM. The 2 most important survival factors are early surgical intervention and adequate drainage.Item Does pathological staging following neoadjuvant therapy (ypTNM) reflect the reality?(Elsevier, 2017-01) Kara, Hasan; Demir, Adalet; Turna, Akif; Toker, Alper; Melek, Hüseyin; Ero, Mehmet; Bayram, Ahmet Sami; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0003-1822-8153; 0000-0003-0684-0900; AAI-5039-2021; ABB-7580-2020; AAE-1069-2022Item Does PET/CT SUVmax value correlate with long-term survival in patients with surgically treated stage I non-small cell lung cancer(Elsevier, 2017-01) Kara, Kasan; Demir, Adalet; Turna, Akif; Toker, Alper; Kaynak, Kamil; Melek, Hüseyin; Çetinkaya, Gamze; Bayram, Ahmet Sami; Erol, Mehmet; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.Item Does the change in body mass index during induction chemo/ chemoradiotherapy affect the outcome of surgery in locally advanced NSCLC(Elsevier, 2018-10) Özer, Erhan; Çetinkaya, Gamze; Deligönul, Adem; Melek, Hüseyin; Sevinç, Tayhan; Kurt, E.; Bayram, Ahmet Sami; Evrensel, Türkkan; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi.; 0000-0002-4848-1566; 0000-0003-0684-0900; 0000-0002-9732-5340; 0000-0003-1822-8153; JDW-2654-2023; ABB-7580-2020; AAJ-1027-2021; JCE-0097-2023; AAI-5039-2021; AAE-1069-2022Item Fatal haemoptysis due to pulmonary artery aneurysm in Behcet's disease(W B Saunders, 1997) Gebitekin, Cengiz; Yılmaz, Meri; Şenkaya, Işık; Saba, D.; Sağdıç, Kadir; Özer, G.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Kalp Damar Cerrahisi Anabilim Dalı.; 6602156436; 35606507600; 6603498369; 6603339291; 6506070344; 57196569090Behçet's disease (BD) was described by the Turkish dermatologist, Hulusi Behcet, in 1937. The main symptoms of the disease vary according to the affected organs such as skin, mucosa, eyes, joints, gastrointestinal tract, vascular system and nervous system. For many years, the known vascular complications of BD have been attributed to thrombophlebitis. However, several reports have been published in recent years relating to cases with aneurysm and arterial occlusion. The aetiology is still unknown; however, vasculitic changes are common in all involved organs, z8 Pulmonary artery aneurysm (PAA) is uncommon in patients with BD. PAA may be bilateral and may also rupture causing sudden death due to massive haemorrhage or haemoptysis from an arteriobronchial fistula. The incidence of vascular involvement in our 183 cases with BD was 28.4% (52 cases) in the last 15 years, PAA was observed in four (2.2%) patients who are reported in this paper.
- «
- 1 (current)
- 2
- 3
- »