Browsing by Author "Can, Fatma Ezgi"
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Item Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response(Elsevier, 2016-05-11) Atasayar, Gülfer; Eryılmaz, Işıl Ezgi; Karlı, Necdet; Egeli, Ünal; Zarifoğlu, Mehmet; Çeçener, Gülşah; Taşkapılıoğlu, Özlem; Tunca, Berrin; Yıldırım, Öznur; Ak, Seçil; Tezcan, Gülçin; Can, Fatma Ezgi; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-1619-6680; 0000-0002-3820-424X; 0000-0002-3316-316X; 0000-0001-7904-883X; 0000-0002-1953-7735; 0000-0002-5956-8755; ABI-6078-2020; AAP-9988-2020; AAH-1656-2021; GWV-3548-2022; AAH-3843-2020; F-8554-2017; AAH-1420-2021; 57189387392; 57189380840; 6506587942; 55665145000; 6603411305; 6508156530; 23037226400; 6602965754; 57189390647; 55253485700; 25650627600; 56689608500Prophylactic therapy response varies in migraine patients. The present study investigated the relationship between the resistance to the drugs commonly used in prophylactic therapy and the possible polymorphic variants of proteins involved in the metabolism of these drugs. Migraine patients with the MDR1 3435TT genotype exhibited a better treatment response to topiramate than migraine patients with the CC and CT genotypes (p = 0.020). The MDR1 C3435T polymorphism was also found to be a higher risk factor for topiramate treatment failure in a comparison of the number of days with migraine (beta(2) = 1.152, p = 0.015). However, there was no significant relationship between the treatment response to topiramate and either the CYP2D6 or CYP2C19 polymorphism, and there were no significant correlations between the treatment responses to amitriptyline, propranolol, and valproic acid and the MDR1, CYP2D6 and CYP2C19 gene polymorphisms. This is the first study to investigate the effect of the polymorphic variants on prophylactic therapy response in migraine patients.Item Association of monocyte to HDL cholesterol level with contrast induced nephropathy in STEMI patients treated with primary PCI(Walter de Gruyter, 2016-05-18) Sağ, Salim; Yıldız, Abdülmecit; Aydın, Kaderli Aysel; Gül, Bülent Cuma; Bedir, Ömer; Ceǧilli, Ercan; Özdemir, Bülent; Can, Fatma Ezgi; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-8974-8837; 0000-0001-8404-8252; 0000-0002-1953-7735; AAI-6632-2021; AAW-9185-2020; 12140008100; 57192158999; 7801322152; 57140207000; 57191868066; 57144621700; 7004168959; 56689608500; 57192164890Background: Contrast induced nephropathy (CIN) has been proven to be a clinical condition related to adverse cardiovascular outcomes. In recent studies, the monocyte to high density lipoprotein ratio (MHR) has been-postulated as a novel parameter associated with adverse renal and cardiovascular outcomes. In this study we-investigated the association of MHR with CIN in-ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). Methods: Consecutive STEMI patients treated with primary PCI were prospectively recruited. Subjects were categorized into two groups; as patients who developed CIN (CIN+) and patients who did not develop CIN (CIN-) during hospitalization. CIN was defined as either a 25% increase in serum creatinine from baseline or 44.20 mu mol/L increase in absolute value, within 72 h of intravenous contrast administration. Results: A total number of 209 patients were included in the study. Thirty-two patients developed CIN (15.3%). In the CIN (+) patients, monocytes were higher [1.02 (0.83-1.39) vs. 0.69 (0.53-0.90) 109/L, p < 0.01] and HDL cholesterol levels were lower [0.88 (0.78-1.01) vs. 0.98 (0.88-1.14) mmol/L, p < 0.01]. In addition, MHR was significantly higher in the CIN (+) group [1.16 (0.89-2.16) vs. 0.72 (0.53-0.95) 10(9)/mmol, p < 0.01]. In multivariate logistic regression analysis, MHR, Mehran score, AGEF score and CV/eGFR were independently correlated with CIN. Conclusions: Higher MHR levels may predict CIN development after primary PCI in STEMI patients.Item B12 vitamini ve folik asit eksikliğinin bilişsel fonksiyonlar üzerine etkisinin değerlendirilmesi(Uludağ Üniversitesi, 2015-03-23) Duran, Selcen; Özyurtlu, Damla; Örün, Muhammet Okay; Sıvacı, Ali Özhan; Demiralay, Ahmet; Türkeş, Nevin; Can, Fatma Ezgi; Taşkapılıoğlu, Özlem; Bakar, Mustafa; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.Gelişmekte olan ülkelerde Vitamin B12 ve folik asit eksikliği önemli bir halk sağlığı sorunudur. Vitamin B12 ve folik asit eksikliğinin bilişsel fonksiyonlar üzerinde olumsuz etkileri olduğu, demans gelişim riskinde artış ile ilişkili olduğu bilinmektedir. Hematolojik tutulum olmadan da nörolojik tutulumun olabileceği bilinmektedir. Bu çalışmada vitamin B12 ve folik asit eksikliğinin hematolojik parametreler ve bilişsel performans üzerindeki etkisinin araştırılması amaçlanmıştır. Çalışmaya 2011-2013 yılları arasında unutkanlık yakınması ile Uludağ Üniversitesi Tıp Fakültesi Nöroloji Polikliniği’ne başvuran 235 olgu dahil edildi. Vitamin B12 ve folik asit düzeylerinin hematolojik parametreler ve bilişsel durum üzerine etkisi retrospektif olarak incelendi. Serumda düşük vitamin B12 düzeyinin bilişsel performans üzerine anlamlı bir etkisi olmadığı görüldü. Ancak yaş gruplarındaki vitamin B12 ve folik asit düzeyleri ele alındığında, ileri yaştaki hastalarda folik asit eksikliğinin, diğer yaş gruplarından daha sık olduğu görüldü (p=0,044). Vitamin B12 ve folik asit eksikliğinin ileri yaştaki hastalarda gözlenebileceği, bu vitaminlerin eksikliği sonucu ortaya çıkan kalıcı nörolojik hasarların tedaviyle önlenebilir olduğuna dikkat çekilmiştir.Item The effect of morphometric and anatomic relationship of gallbladder to the liver on standard laparoscopic cholecystectomies and proposal of a new anatomical classification(Verduci Publisher, 2016-04) Duman, Uğur; Erol, F.; Dilektaşlı, Evren; Doğan, Gözde; Dandin, Özgür; Tihan, Deniz Necdet; Kafa, İlker Mustafa; Can, Fatma Ezgi; Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0001-8309-0934; AAG-7125-2021; 14058991800; 8450193200; 56689608500OBJECTIVE: Anatomical variations of the extrahepatic biliary tree are frequently seen and may cause challenging conditions for surgeons. We aimed to investigate the morphological variations of the gall-bladder in patients who underwent cholecystectomy and their effects during and after the surgery, by using a new anatomical classification. PATIENTS AND METHODS: Dissection time, perioperative bleeding, perioperative/postoperative complication rates, the difference between preoperative/postoperative hematocrit and leukocyte levels of 164 symptomatic cholelithiasis patients who underwent laparoscopic cholecystectomy were evaluated. The patients' gallbladders were categorized in "seven" different types regarding their anatomical positions and morphometric relations with the liver's acute margin and fossa of the gallbladder. Relations between these gallbladders types and perioperative/postoperative parameters were also examined. RESULTS: The median time to complete the dissection of the gallbladder from the fossa was 375.5 seconds. The mean length of the fossa was 68.06 +/- 15.08 mm, the average size of the gallbladder was 92.10 +/- 18.79 mm. A positive correlation was found between dissection time and length of fossa vesica and also in the size of the gallbladder (p = 0.003, p = 0.034). Moreover, a positive correlation was found between the dissection time and the perioperative perforation risk of the gallbladder (p = 0.005). The most common type of gallbladder was type I and III (23.2%). The least common gallbladder type among the patients assessed as part of the study was type VI (6.7%). When the gallbladder types were compared, the perioperative perforation rate of the gallbladder wall was found to be significantly higher in morphological type V (p = 0.014). CONCLUSIONS: The perioperative perforation rate of the gallbladder wall was found significantly higher in morphological type V. To perform a safe cholecystectomy, surgeons should be aware of anatomical variations of the gallbladder and its relations with the liver parenchyma, which are important for surgical strategies.Item Examination of published articles with respect to statistical errors in veterinary sciences(Sciendo, 2016-12-07) Mankir, Seray; Ercan, İlker; Kaya, Mehmet Onur; Uzabacı, Ender; Can, Fatma Ezgi; Bashir, Albishir Musa; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Biyoistatistik Anabilim Dalı.; 0000-0001-8052-0484; 0000-0002-9634-0055; 0000-0002-1953-7735; 0000-0002-2382-290X; ABF-2367-2020; V-9415-2018; 6603789069; 56689249200; 55347697800; 56689608500; 57193810863The aim of this present work was to examine statistical errors in published veterinary science articles. A total of 204 published articles (SCI or SCI-Exp) were used in this study. The articles were chosen from among those indexed in PubMed database between the years 2010 and 2014, inclusive. A total of 199 articles had at least one statistical error. The most frequently encountered statistical error among the articles published in journals indexed in SCI and in SCI-E was "errors in summarizing data". No statistical error was found in 2.45% (n=5) of 204 (SCI: 0.98% (1/102), SCI-E: 3.92% (4/102)) articles. To reduce and prevent statistical errors in publications, the researchers must have a basic knowledge of statistics and during the study process they must consult field experts. While reviewing, the reviewers have to redirect the publications to statistical editors when needed and most importantly during the process of editing, the editors have to direct the publications to a statistics reviewer.Item General and abdominal obesity prevelances and their relations with metabolic syndrome components(Professional Medical Publications, 2019-07) Göktaş, Olgun; Ersoy, Canan; Ercan, İlker; Can, Fatma Ezgi; Uludağ Üniversitesi/Tıp Fakültesi.; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü.; Uludağ Üniversitesi/Aile Sağlığı Merkezi.; 0000-0003-3291-5187; AAH-8861-2021; ABF-2367-2020; 6603078279; 6701485882; 6603789069; 56689608500Objective: To evaluate the frequency of obesity and its relation of metabolic syndrome. Methods: The data from the records of the consecutive adult residents of Bursa province in Turkey who were admitted to the family health centers from the 1st January to the 31st December 2016 were evaluated retrospectively. The population size was 2901396 (N) and the sample size was at least n=17729. A total of 17812 participants (10939 females, 6873 males) were included in this retrospective observational study. Sociodemographic characteristics, diseases, used medication and smoking, height, weight, waist and hip circumferences (WaC and HC) were recorded from the files. Results: The mean age of all subjects was 46.1 years, the mean BMI was 28.1 kg/m(2) with a mean WaC of 91.3 cm, HC of 104.7 cm, WHR of 0.87. The prevalence of obesity in Bursa was found to be 32.2% (37.8% in females and 23.3% in males) according to BMI, 63.2% (69.7% in females, 52.9% in males) according to waist and hip circumferences. Conclusions: Preventive measures should be taken by health authorities to prevent the rapid increase in general and abdominal obesity that may lead to serious comorbidities.Publication Impact of Storage Period on CD4+/CD8+ T Lymphocyte Ratio in Erythrocyte Suspensions(Turkish Soc Immunology, 2020-01-01) Bal, Salih Haldun; BAL, SALİH HALDUN; Kumaş, Levent Tufan; Heper, Yasemin; HEPER, YASEMİN; Budak, Ferah; BUDAK, FERAH; Göral, Guher; Can, Fatma Ezgi; Oral, Haluk Barbaros; ORAL, HALUK BARBAROS; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/BioistatistikAnabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.; 0000-0001-7625-9148; 0000-0003-0463-6818; JSL-7718-2023; HJY-9001-2023; K-7285-2012; F-4657-2014; AAH-6506-2021; IZP-9398-2023Introduction: Some immunologic changes in the recipient derived by allogeneic blood transfusion (ABT) are called Transfusion Related Immune Modulation (TRIM). Despite the exact mechanisms of these changes are not known, it is thought that ABT causes a decrease of CD4/CD8 ratio in the recipient. This study aimed to determine the CD4/CD8 ratio in stored erythrocyte suspensions (ES) and to obtain new information about TRIM mechanisms.Materials and Methods: Whole blood components used in our study were collected from 10 healthy volunteers. ES' obtained from whole blood were divided into three equal aliquots. Test samples which were related to 0th, 21st and 42nd storage days were prepared from these aliquots. CD3, CD4 and CD8 surface markers in peripheral blood mononuclear cells were investigated with flow-cytometer in these test samples.Results: Our data were evaluated according to storage days. Decrease of CD3 (p=0,001), CD4 (p<0,001), CD8 (p=0,012) expressing mononuclear blood cells and helper T cells in 21st-day samples, CD4 (p=0,035) and CD8 (p=0,017) expressing cells in 42nd-day samples compared to Day 0 samples and increase of CD3 (p=0,027) expressing cells in 42nd-day samples compared to 21st-day samples were found statistically significant.Conclusion: In our study, we did not find any significant change in the ratio of CD4(+)/CD8(+) cells in ES. Detailed studies can help us to obtain more comprehensive knowledge on this field.Item Kayıp landmark tahmininde kullanılabilecek yöntemlerin performansının karşılaştırılması ve F yaklaşımının önerilmesi(Bursa Uludağ Üniversitesi, 2020-01-28) Can, Fatma Ezgi; Ercan, İlker; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Biyoistatistik Anabilim Dalı.İstatistiksel şekil analizi; nesnelerden elde edilen geometrik bilginin kullanıldığı yöntemleri içermektedir. İstatistiksel şekil analizinde geometrik bilginin kullanılmasında en önemli girdi landmarklardır. Şekil analizinde kayıp veriler landmark koordinatlarına ait bilgi kaybı olduğu durumda ortaya çıkmaktadır. Landmarkların kartezyen koordinatlarında veri kaybı meydana gelmesi o landmarkı kullanılamaz hale getirerek ilgili birimin araştırmadan çıkmasına yol açmaktadır. Tez çalışmasında kayıp landmarkların tahminine yönelik kullanılan EM algoritması, çoklu regresyon atama, Bayes yaklaşımlı temel bileşenler analizi, olasılıksal temel bileşenler analizi, ters doğrusal olmayan temel bileşenler analizi ve iteratif kısmi en küçük kareler ile doğrusal olmayan tahmine dayalı temel bileşenler analizi yöntemleri ve amaca yönelik olarak tez çalışması kapsamında önerilen min(F) ve max(F) yaklaşımının performansı değerlendirilmiştir. Simülasyon senaryosunda landmark sayıları 3, 6, 9 ve 12 ve örneklem büyüklükleri 30, 50 ve 100 olarak alınmıştır. Çok değişkenli normal dağılımdan isotropik ve isotropik olmayan modellere dayalı olarak veri türetilmiş ve 10 farklı simülasyon senaryosu dikkate alınmıştır. Küçük, orta ve büyük örneklem büyüklükleri dikkate alındığında, performans değerlendirmesinde en iyi ve en farklı sonucu, tez çalışmasında önerilen F-yaklaşımı algoritması Min(F) ölçütü vermiştir.Item A nonnormal look at polychoric correlations: Modeling the change in correlations before and after discretization(Springer, 2016-03-08) Demirtaş, Hakan; Ahmadian, Robab; Atış, Sema; Can, Fatma Ezgi; Ercan, İlker; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Bölümü.; 0000-0003-1550-639X; 0000-0002-2382-290X; 0000-0002-1953-7735; AAE-5602-2019; 56689608500; 57185433800; 57185484200; 6603789069Two algorithms for establishing a connection between correlations before and after ordinalization under a wide spectrum of nonnormal underlying bivariate distributions are developed by extending the iteratively found normal-based results via the power polynomials. These algorithms are designed to compute the polychoric correlation when the ordinal correlation is specified, and vice versa, along with the distributional properties of latent, continuous variables that are subsequently ordinalized through thresholds dictated by the marginal proportions. The method has broad applicability in the simulation and random number generation world where modeling the relationships between these correlation types is of interest.Item Periorbital soft tissue anthropometric analysis of young adults(Lippincott Williams & Wilkins, 2016-12-10) Özdemir, Turan; Can, Fatma Ezgi; Işıklar, Sefa; Ercan, İlker; Cankur, Nedim Şimşek; Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Anatomi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-1953-7735; 0000-0002-2070-5193; 0000-0002-2382-290X; AAK-3779-2021; ABF-2367-2020; 57193330838; 56689608500; 57193335308; 6603789069; 8265670800The authors aim to determine the periorbital soft tissue anthropometric norms for Turkish young adults for right and left eyes using a noninvasive two-dimensional photogrammetric analysis. Anthropometric measurements of the periorbital soft tissue were taken from 172 female and 56 male Turkish adults aged between 18 and 24 years. The periorbital soft tissue profiles (ocular and palpebral) for males and females were digitally analyzed using linear measurements made with standardized photographic records, taken in a natural head position. Statistically significant differences were found for ocular soft tissue measurements according to gender except inner intercanthal distance (P = 0.125) and right horizontal palpebral aperture (P = 0.240). Statistically significant differences were found for palpebral soft tissue measurements according to gender except right pretarsal skin height (P = 0.112) and left pretarsal skin height (P = 0.056). Results were compared with other ethnic groups. Normal periorbital soft tissue measurements are fundamental anatomical parameters utilized in ophthalmology, optometry, ophthalmic industry, oculoplastic surgery, clinical genetics, dermatocosmetology. Further, normal anthropometric measurements generate reference data for studies in craniofacial dysmorphology, oculoplastic surgery, dermatocosmetology, and comparative physical anthropology.Item Primary glomerulonephritis: A single-center retrospective experience(Carbone Editore, 2016-09-02) Ayar, Yavuz; Ersoy, Alparslan; Can, Fatma Ezgi; Güllülü, Mustafa; Bayrakcı, İsmail; Demirayak, Dilay; Düger, Hakan; Ocak, Tuğba; Oruç, Ayşegül; Yıldız, Abdülmecit; Korkut, Bayram; Şahin, Ahmet Bilgehan; Camcı, Nihal Yücel; Vuruşkan, Berna Aytaç; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-7846-0870; 0000-0001-5478-3192; 0000-0003-4607-9220; 0000-0002-0710-0923; 0000-0003-4607-9220; 0000-0003-4607-9220; AAH-4002-2021; AAM-4927-2020; GPK-6118-2022; O-9948-2015; AAH-9746-2021; AAH-5054-2021; GSE-0029-2022; GDL-7686-2022; CTG-8811-2022; ELN-3407-2022; EQO-1344-2022; FPM-3131-2022; HIG-9032-2022; FFH-4157-2022; CHG-6819-2022; 55860143300; 35612977100; 56689608500; 6602684544; 57191504355; 57191498699; 58423722100; 57191501503; 55133912100; 56256977500; 57191504817; 57188809248; 57191628115; 56527372000Aim: Primary glomerular diseases (PGD) are seen frequently. Age, gender, geographical characteristics and genetic affect the distribution of the disease. Despite the treatment, a part of the disease may progress to end-stage renal disease. We evaluated the PGD patients and retrospectively regarding to their clinical and histopathological characteristics.Materials and methods: In this study PGD patients, who have had renal biopsy between 1st January 2009 and 31st December 2014 were evaluated. Clinical and laboratory characteristics, response of the treatment, biopsy evidences, and the risk factors associated with mortality were analyzed. We also compared the cases of primary glomerulonephritis retrospectively. The mean value of the follow-up periods was 22 months (range: 8 - 76 months).Results: The median age was 42 years (18 - 80) in 264 patients. When five groups were compared, there was statistically important difference between the groups (p < 0.001). The distributions of PGD subgroups were 40.5% for membranous glomerulonephritis (MGN), 20.4% for IgA nephropathy (IgAN), 25.7% for focal segmental glomerulosclerosis (FSGS), 7.9% for minimal change disease (MCD) and 5.3% for membranoproliferative glomerulonephritis (MPGN). The distrubition of gender was not significantly in the five PGD groups (p=0.269). Nephrotic syndrome was the most biopsy indication in MGN patients (76.6%). Nephritic syndrome was more seen in immunoglobulin A nephropathy (IgAN) patients (63%). Chronic kidney disease was more detected in focal segmental glomerulosclerosis (FSGS) patients as biopsy indication (p<0.001). Minimal change disease (MCD) and IgAN patients were more received with steroid treatment (85.7% and 55.5% respectively). Cyclophosphamide was more received in MGN patients. Serum IgG levels were more higher in FSGS and IgAN patients (p<0.001). Partial remission was more seen in MCD patients. Complete remission was more detected in MGN and FSGS patients. 29.1% of IgAN patients were not received treatment response. Six year renal survival rates were 84.1% (MGN), 87.1% (IgAN), 95.3% (MCD), 64.3% (MPGN) and 76.5% (FSGS) respectively.Conclusion: Biopsy maintains its diagnostic importance in glomerular diseases. Renal functions at diagnosis are important in response to treatment. Early diagnosis, follow-up and appropriate immunosuppressive medications affect mortality and clinical progress in PGD.Item Statistical errors in articles published in radiology Journals(Galenos Publ House, 2018-06-12) Günel Karadeniz, Pınar; Seçil, Mustafa; Uzabacı, Ender; Kuyuk, Sema Atış; Kesin, Fisun Kaskır; Can, Fatma Ezgi; Ercan, İlker; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; ABF-2367-2020; 55347697800; 57207846547; 57207844301; 56689608500; 6603789069PURPOSE We aimed to evaluate articles in radiology journals indexed in the Science Citation Index or Science Citation Index Expanded in terms of statistical errors. By this means, we aim to contribute to the production of high quality scientific publications. METHODS In this study, a total of 157 articles published in 2016-2017 in 20 radiology journals were reviewed randomly. Selected articles were evaluated for statistical errors regarding P values and statistical tests, and for errors in terminology and other errors related to interpretation. In addition, in order to examine whether the error rates of the articles published in the radiology journals differed according to the impact factor, the statistical errors were compared according to the impact factors of the journals. RESULTS Of the 157 articles published in radiology journals, 10 had no statistical errors, while 147 had at least one statistical error. The most frequently encountered error was "errors in summarizing data" with a rate of 66%. This was followed by "incorrect representation of P values" with a rate of 42%. The least frequently encountered error was "statistical symbol errors" with a rate of 3%. There was no statistically significant difference according to impact factors. CONCLUSION In conclusion, radiology journals, as do journals in different fields, include articles containing statistical errors. Even when the quality of the journal increases, there is no difference in these statistical error rates. In order to prevent statistical errors in manuscripts, there are responsibilities for both the researchers who conduct scientific studies and the editors who publish these studies in their journals. Researchers should have a basic statistical knowledge, and the editor must submit all manuscripts for a statistical review.Publication The impact of gamma irradiation on exosome profiles and electrolyte levels in apheresis platelet concentrates(Wiley, 2021-08-01) Bal, Salih Haldun; Karaçay, Mehmet; Kızmaz, Muhammed Ali; Kumaş, Levent Tufan; Can, Fatma Ezgi; Gülkaya, Deniz Koşay; Ermiş, Diğdem Yöyen; Budak, Ferah; Heper, Yasemin; Oral, Haluk Barbaros; BAL, SALİH HALDUN; Karaçay, Mehmet; Kızmaz, Muhammed Ali; Kumaş, Levent Tufan; Can, Fatma Ezgi; Gülkaya, Deniz Koşay; YÖYEN ERMİŞ, DİĞDEM; BUDAK, FERAH; HEPER, YASEMİN; ORAL, HALUK BARBAROS; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dr. Raşit Durusoy Kan Bankası.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Bioistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; 0000-0001-5334-7911; 0000-0001-7625-9148; 0000-0003-0463-6818; JSL-7718-2023; HKN-2347-2023; K-7285-2012; F-4657-2014; IZP-9398-2023; KBR-5535-2024; JHB-7829-2023; FHB-1791-2022; CSL-9726-2022; GYL-2038-2022; HOK-0035-2023; CTY-9474-2022Publication Three-dimensional analysis of craniofacial shape in obstructive sleep apnea syndrome using geometric morphometrics(Soc Chilena Anatomia, 2019-01-01) Can, Fatma Ezgi; Özdemir, Senem Turan; ÖZDEMİR, SENEM; Ercan, İlker; ERCAN, İLKER; Ocakoğlu, Gökhan; OCAKOĞLU, GÖKHAN; Çetinoğlu, Ezgi Demirdöğen; Ursavaş, Ahmet; URSAVAŞ, AHMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Bioistatistik Anabilim Dalı.; 0000-0002-2382-290X; 0000-0002-1114-6051; 0000-0002-7400-9089; HLG-6346-2023; AAI-3169-2021; AAH-5180-2021; AAA-8734-2021; ABF-2367-2020; JPK-7012-2023Craniofacial morphology is a risk factor for obstructive sleep apnea syndrome. The general aim of this study was to investigate the craniofacial shape differences in adults with and without obstructive sleep apnea syndrome, using geometric morphometric methods. A descriptive study conducted in 106 adult Turkish subjects, consisting of 50 patients with OSAS diagnosed by polysonmography and 56 non-OSAS controls. Tlree dimensional craniofacial scanning processes were performed on patient subjects on the same day as the PSG. Twelve standard craniofacial landmarks were collected from each subject's 3D craniofacial scan. Geometric morphometric analysis was used to compare the craniofacial shape differences between the OSAS and non-OSAS control groups. No statistically significant difference in terms of general shape in face shapes was found between the OSAS group and control group. However, local significance differences were found. There were significant differences between the groups in some of the interlandmark distances: 11 % of the interlandmark distances were greater in OSAS patients, and 29 % were greater in controls. Greater measured distances in OSAS are concentrated in the nasal region. In the control group, the difference is not concentrated in a specific region. Given the relationship of craniofacial structural alterations and sleep disordered breathing, we hypothesized that inter-landmark distance measurements in the craniofacial anatomy of patients might be predictive of OSA.Item Vitamin D status in the adult population of Bursa-Turkey(Taylor & Francis, 2020-11-02) Can, Fatma Ezgi; Göktaş, Olgun; Ersoy, Canan; Ercan, İlker; Bursa Uludağ Üniversitesi/Aile Sağlığı Merkezi/Aile Sağlığı Birimi.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı Endokrinoloji ve Metabolizma Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-2382-290X; AAH-8861-2021; EXQ-8413-2022; 6603078279; 6701485882; 6603789069Background Vitamin D, along with parathyroid hormone (PTH) and calcitonin, is an important hormone that affects bone and calcium metabolism. Objectives To evaluate the vitamin D status and its seasonal variation in the adult population of Bursa. Methods Since there is not enough information about vitamin D levels, 25 OH vitamin D levels were analysed retrospectively from the records of 11,734 adult subjects (9142 women, 2592 men) admitted to 24 family health centres located in different districts of Bursa between 1 December 2017 and 30 November 2018. Some tests that can affect vitamin D levels, demographic features, and accompanying comorbidities were also evaluated. A face-to-face questionnaire was administered to subjects who were willing to answer (n = 2965). Results The mean serum vitamin D level was 16.6 +/- 11.5 ng/mL in the entire population, 15.8 +/- 11.7 ng/mL in women and 19.5 +/- 9.9 ng/mL in men. The percentage of subjects with a vitamin D level <20 ng/mL was highest in March-May and lowest in the September-November period (80.7% and 69.9% for women, 77.5% and 32.9% for men, respectively). Conclusion Vitamin D levels <20 ng/mL are more prominent in women, and decline in spring, in the adult population of Bursa. These results are meaningful for the population living in Bursa, Turkey and the northern European region.