Browsing by Author "Can, Demet"

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Akut generalize ekzantematöz püstülozis
(Uludağ Üniversitesi, 2013-02-14) Nacaroğlu, Hikmet Tekin; Can, Demet
Akut generalize ekzantematöz püstülozis (AGEP), klinik olarak ani başlayan, ateşle birlikte tüm vücutta yaygın püstüler döküntü ile seyreden nadir bir dermatozdur. Vakaların %90’nında ilaç kullanım öyküsü mevcut olmakla birlikte etyopatogenezde nadiren viral ve bakteriyel enfeksiyonlar ile civaya karşı aşırı duyarlılık reaksiyonları da suçlanmaktadır. Klinik olarak eritemli zemin üzerinde, foliküler yerleşimli olmayan, çok sayıda steril püstülle karekterizedir. Hastalığın spesifik bir tedavisi yoktur, altta yatan nedenin ortadan kaldırılması ile spontan iyileşme gözlenir. Bu makalede AGEP’in etiyolojik, klinik ve histopatolojik özellikleri gözden geçirilmiştir.
Anaphylaxis in Turkish children: A multi-centre, retrospective, case study
(Wiley, 2011-12) Orhan, Fazıl; Bakırtaş, Arzu; Yılmaz, Özge; Boz, Ayşen Bingöl; Can, Demet; Kuyucu, Semanur; Harmancı, Koray; Tahan, Fulya; Reisli, İsmail; Karakaş, Taner; Baki, Ali Erdem; Çokuğraş, Haluk; Çakır, Murat; Canıtez, Yakup; Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Alerji ve İmmünoloji Anabilim Dalı.; 8988954700
Background Anaphylaxis is a serious and potentially lethal systemic reaction affecting more than one organ or system. Objective We aimed to describe the demographic characteristics, clinical features, causes, settings, and administered therapy in Turkish children. Methods This retrospective, case note study included all children referred to the outpatient clinics of the Pediatric Allergy Departments of the participating study centres from 1 July 1999 to 30 June 2009 for investigation of anaphylaxis or who were seen by us at the moment of the reaction during the same period and who met the clinical criteria of anaphylaxis. Results Two hundred and twenty-four cases of anaphylaxis were reported in 137 children (88 boys, P = 0.0001). The mean +/- SD age at the referral was 7.7 +/- 4.2 years (range: 4 months-17 years). Ninety-eight episodes (43.8%) occurred at home. The symptoms were cutaneous in 222 (99.1%) episodes, respiratory in 217 (96.9%), neuro-psychiatric in 118 (52.7%), cardiovascular in 92 (41.1%), and gastrointestinal in 88 (39.3%). Biphasic reaction was reported in seven episodes (3.1%, 95% CI: 1.5-6.3). Death occurred in one case (0.4%, 95% CI: 0.08-2.4). Treatment was available in 158 episodes (70.5%). Of them, 148 (93.7%) received antihistamines, 132 (83.5%) corticosteroids, 51 (32.3%) epinephrine, and 17 (10.8%) beta-2-mimetics. The causative agents were foods in 86 (38.4%) episodes, hymenoptera venom in 84 (37.5%), drugs and medications in 47 (21.0%), and latex in 5 (2.2%). In two episodes (0.9%), the causative agent was unidentified. Allergy to the trigger was known prior to anaphylaxis in 116 (51.8%) episodes. An epinephrine autoinjector had been prescribed for 70 children (51.1%). Conclusions and Clinical Relevance Anaphylaxis was seen significantly more in boys. Most of the reactions occurred at home. Foods were the most frequent cause. Epinephrine, the first-line treatment of anaphylaxis, was administered in only a third of the children.
Awareness of allergy in Turkey
(Wiley, 2010-06) Kalpaklıoğlu, Ayşe Füsun; Kalkan, İlkay Koca; Akçay, Ahmet Oğuz; Reisli, İsmail; Can, Demet; Yüksel, Hasan; Kırmaz, Cengiz; Gülen, Figen; Ediger, Dane; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; AAE-9142-2019
Cftr mutations unidentified in cftr2 database and their phenotypic characteristics: Data from cystic fibrosis registry of Turkey
(European Respiratory Soc Journals Ltd, 2020-09-07) Cinel, Güzin; Dogru, Deniz; Çakir, Erkan; Eyüboğlu, Tuğba Şişmanlar; Çobanoğlu, Nazan; Pekcan, Sevgi; Yalçın, Ebru; Kiper, Nural; Sen, Velat; Sen, Hadice Selimoğlu; Ercan, Ömür; Keskin, Özlem; Eltan, Sevgi Bilgiç; Al Shadfan, Lina Muhammed; Yazan, Hakan; Altıntaş, Derya Ufuk; Sasihüseyinoğlu, Şenay; Cokugras, Haluk; Atabek, Ayşe Ayzıt; Gürsoy, Tuğba Ramaşlı; Aslan, Ayşe Tana; Bingol, Aysen; Başaran, Abdurrahman Erdem; Özdemir, Ali; Köse, Mehmet; Hangül, Melih; Emiralioğlu, Nagehan; Tuğcu, Gökçen; Yüksel, Hasan; Yılmaz, Özge; Orhan, Fazıl; Aydın, Zeynep Gokçe Gayretli; Topal, Erdem; Tamay, Zeynep; Can, Demet; Bal, Cem Murat; Çaltepe, Gönül; Özçelik, Uğur; Sapan, Nihat; SAPAN, NİHAT; Çekiç, Sükrü; ÇEKİÇ, ŞÜKRÜ; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-9574-1842; L-1933-2017; FUI-8766-2022
Characteristics and prognosis of childhood atopic dermatitis: A multi-center study in Turkey
(Wiley, 2009) Yüksel, Hasan; Can, Demet; Reisli, İsmail; Uzuner, Nevin; Orhan, Fazıl; Cevit, Ömer; Tahan, Fulya; Kuyucu, Semanur; Boz, Bingol A.; Akçay, Ahmet Oğuz; Yılmaz, Özge; Canıtez, Yakup; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
Characteristics and prognosis of childhood atopic dermatitis: A multicenter study in Turkey
(Karger, 2010) Yüksel, Hasan; Can, Demet; Reisli, İsmail; Uzuner, Nevin; Orhan, Fazıl; Cevit, Ömer; Tahan, Fulya; Kuyucu, Semanur; Bingöl, Ayşen Boz; Akçay, Ahmet; Yılmaz, Özge; Canıtez, Yakup; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 8988954700
Background: Childhood atopic dermatitis (AD) is classically accepted as initial finding of atopic march; however, non-atopic cases do not follow this course. The aim of this study was to determine the characteristics and prognosis of AD in childhood in Turkey. Methods: The study included 531 children with AD that presented to pediatric allergy departments in 11 different regions of Turkey. Age at diagnosis, total serum and inhalant-specific immunoglobulin E (IgE) levels and allergen skin prick test results were recorded retrospectively. Clinical characteristics like additional allergic diseases at presentation or during follow-up were recorded as well as duration of follow-up. Results: Mean age at diagnosis was 37.8 +/- 36.2 months. Mean IgE level was 318.3 +/- 677.8 IU/ml (median 100 IU/ml). Skin prick tests yielded positive results in 47% of children. At presentation, 31.6% of children reported additional allergic disease, while 11.7% developed allergic disease during follow-up. Among all, 46.6% had additional allergic disease at any point. IgE levels were significantly higher in children with additional allergic diseases (p = 0.001). Allergen skin prick test positivity and family history of allergic diseases increased the risk of additional allergic diseases significantly (OR = 3.90, 95% CI = 2.3-6.6 and OR = 1.89, 95% CI = 1.3-2.8, respectively). Conclusions: Allergic sensitization is not present in all cases of AD. Coexistence of additional allergic diseases is not as high as expected but more common in children who have been demonstrated to have atopic sensitization with high IgE levels and allergen skin prick test positivity.
Patients eligible for modulator drugs: Data from cystic fibrosis registry of Turkey
(John Wiley, 2020-09) Çobanoğlu, Nazan; Özçelik, Uğur; Çakır, Erkan; Şişmanlar Eyüboğlu, Tuğba; Pekcan, Sevgi; Cinel, Güzin; Yalçın, Ebru; Kiper, Nural; Emiralioğlu, Nagehan; Şen, Velat; Şen, Hadice Selimoğlu; Ercan, Ömür; Çokuğraş, Haluk; Kılınç, Ayşe Ayzıt; Al Shadfan, Lina Muhammed; Yazan, Hakan; Altıntaş, Derya Ufuk; Karagöz, Dilek; Demir, Esen; Kartal Öztürk, Gökçen; Bingöl, Ayşen; Başaran, Abdurrahman Erdem; Çelebioğlu, Ebru; Aslan, Ayşe Tana; Gürsoy, Tuğba Ramaslı; Tuğcu, Gökçen; Özdemir, Ali; Harmancı, Koray; Yıldırım, Gonca Kılıç; Köse, Mehmet; Hangül, Melih; Tamay, Zeynep; Süleyman, Ayşe; Yüksel, Hasan; Yılmaz, Özge; Özcan, Gizem; Topal, Erdem; Can, Demet; Korkmaz Ekren, Pervin; Çaltepe, Gönül; Özdoğan, Şebnem; Korkmaz Ekren, Pervin; Doğru, Deniz; Sapan, Nihat; Çekiç, Şükrü; Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Bölümü; 0000-0002-9574-1842; 0000-0002-7601-8392; FUI-8766-2022; L-1933-2017; 6602156485; 56117061000
Background: A better understanding of cystic fibrosis transmembrane conductance regulator biology has led to the development of modulator drugs such as ivacaftor, lumacaftor-ivacaftor, tezacaftor-ivacaftor, and elexacaftor-tezacaftor-ivacaftor. This cross-sectional study evaluated cystic fibrosis (CF) patients eligible for modulator drugs. Methods: Data for age and genetic mutations from the Cystic Fibrosis Registry of Turkey collected in 2018 were used to find out the number of patients who are eligible for modulator therapy. Results: Of registered 1488 CF patients, genetic analysis was done for 1351. The numbers and percentages of patients and names of the drugs, that the patients are eligible for, are as follows: 122 (9.03%) for ivacaftor, 156 (11.54%) for lumacaftor-ivacaftor, 163 (11.23%) for tezacaftor-ivacaftor, and 57 (4.21%) for elexacaftor-tezacaftor-ivacaftor. Among 1351 genotyped patients total of 313 (23.16%) patients are eligible for currently licensed modulator therapies (55 patients were shared by ivacaftor and tezacaftor-ivacaftor, 108 patients were shared by lumacaftor-ivacaftor and tezacaftor-ivacaftor, and 22 patients were shared by tezacaftor-ivacaftor and elexacaftor-tezacaftor-ivacaftor groups). Conclusions: The present study shows that approximately one-fourth of the registered CF patients in Turkey are eligible for modulator drugs. As, frequent mutations that CF patients have in Turkey are different from North American and European CF patients, developing modulator drugs effective for those mutations is necessary. Furthermore, as modulator drugs are very expensive currently, financial support of the government in developing countries like Turkey is noteworthy.
Pulmoner arteriyovenöz malformasyonda klasik triad: Çomak parmak, siyanoz ve polisitemi
(Uludağ Üniversitesi, 2013-03-14) Nacaroğlu, Hikmet Tekin; Gülle, Saniye; Bağ, Özlem; Alper, Hüdaver; Bak, Mustafa; Can, Demet
Pulmoner arteriyovenöz malformasyonlar (PAVM) anormal kapiller gelişimden kaynaklanan, genellikle konjenital lezyonlardır. Lezyonlar izole tek bir anomali şeklinde görülebileceği gibi otozomal dominant geçişli herediter hemorajik telenjiektazi (Rendu-Osler-Weber sendromu; ROWS) ile birlikte çok sayıda da olabilir. Bu vakalar asemptomatik olabilecekleri gibi efor dispnesi, çarpıntı ve çabuk yorulma da görülebilir. Klasik radyolojik görünümü yuvarlak, düzgün sınırlı lezyonlardır. Bilgisayarlı toraks tomografisi ve anjiyografi de teşhis için faydalıdır.Burada çomaklaşma ve siyanoz ile PAVM tanısı alan 2 ve 13 yaşlarında iki kız olgu sunulmuştur.
The reliability and validity of the Turkish version of a childhood asthma control test
(Wiley, 2011-06) Soyer, Özge; Keskin, Özlem; Uzuner, Nevin; Yazicioglu, Mehtap; Kilic, Murat; Artac, Hasibe; Ozmen, Serap; Can, Demet; Zeyrek, D.; Çokuğraş, Haluk C.; Aydogan, Metin; Kuyucu, Semanur; INal, A.; Gurkan, Fuat; Orhan, Fazil; Yilmaz, Ozge; Boz, Bingol A.; Tahan, Fulya; Cevit, Ömer; Sekerel, B.; Sapan, Nihat; Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Alerji ve İmmünoloji Anabilim Dalı.
The reliability and validity of Turkish version of childhood asthma control test
(Springer, 2012-05) Şekerel, Bülent E.; Soyer, Özge Uysal; Keskin, Özlem; Uzuner, Nevin; Yazıcıoğlu, Mehtap; Kılıç, Mehmet; Artaç, Hasibe; Özmen, Serap; Can, Demet; Zeyrek, Dost; Çokuğraş, Halük; Aydoğan, Metin; Kuyucu, Semanur; İnal, Ayfer; Gürkan, Fuat; Orhan, Fazıl; Yılmaz, Özge; Boz, Ayşen Bingöl; Tahan, Fulya; Cevit, Ömer; Canıtez, Yakup; Uludağ Üniversitesi/Tıp Fakültesi.; 8988954700
Introduction: The reliability and validity of Turkish version of Childhood Asthma Control Test (C-ACT). Purpose: The management of asthma is an important as well as difficult issue of physician's daily practice particularly in busy clinical settings. C-ACT was created to identify asthma control levels in children aged 4-11 years. Our aim was to evaluate the reliability, validity and responsiveness of C-ACT in a Turkish sample of children with asthma. Method: In this multicenter study, 368 children were enrolled. C-ACT was completed every month by parents and patients who were evaluated in 3 visits within 2 month intervals. At each visit, physicians interpret the control level and decided for the treatment step as established in GINA guidelines. Results: The internal consistency reliability of the Turkish version of C-ACT (C-ACT1 to C-ACT5) was found to be 0.82, 0.83, 0.82, 0.82 and 0.80, respectively (reliability statistics, Cronbach's alpha). Test-retest reliability was 0.71. There was significant correlation between C-ACT and physician's assessment of asthma control at visit 1 (r = 0.65, P < 0.001). Conclusions: Turkish version of C-ACT is an accurate and reliable tool to evaluate asthma control in children aged 4-11 years. Its widespread use may facilitate appropriate assessment of asthma control and may lead to decrease the number of uncontrolled patients.
The utility of childhood asthma control test and its relationship with control measures and with the decisions made by asthma specialist
(Mosby-Elsevier, 2010-02) Şekerel, Bülent Enis; Keskin, Özlem; Uzuner, Nevin; Yazıcıoğlu, Mehtap; Kılıç, Murat; Artaç, Hasibe; Özmen, Serap; Can, Demet; Zeyrek, D.; Çokuğraş, Haluk; Soyer, Özge; Aydoğan, Metin; Kuyucu, Semanur; İnal, A.; Gürkan, Fuat; Orhan, Fazıl; Yılmaz, Özge; Bingöl, Ayşen; Tahan, Fulya; Cevit, Ömer; Sapan, Nihat; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.