Browsing by Author "Blaser, Kurt"

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IL-10 and TGF- beta cooperate in inducing peripheral T cell tolerance during specific immunotherapy with inhalant allergens and during natural allergen exposure
(Mosby Elsevier, 2001-02) Jutel, Marek; Malolepszy, Josef; Casaulta, Carmen; Wrzyszcz, Maria; Blaser, Kurt; Budak, Ferah; Akdiş, Mübeccel; Akdis, Cezmi; Uludağ Üniversitesi/Tıp Fakültesi/Klinik Immunoloji Anabilim Dalı.; 0000-0001-8020-019X; F-4657-2014; AAV-4844-2020
Key role of regulatory cytokines TGF-beta and IL-10 as well as allergen-specific IgA and IgG4 in tolerance to mucosal antigens/allergens
(Mosby- Elsevier, 2002-01) Jutel, Marek; Malolepszy, Josef; Aebischer, Casaultra C.; Wrzyszcz, Maria; Blaser, Kurt; Akdiş, Mübeccel; Budak, Ferah; Akdiş, Cezmi; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; AAV-4844-2020; F-4657-2014
Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26
(Wiley, 2006) Kotenko, Sergei V.; Yılmaz, Mustafa; Mani, Orlando; Zumkehr, Judith; Blaser, Kurt; Akdiş, Cezmi A.; Akdiş, Mübeccel; Oral, Haluk B; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı/İmmünoloji Bölümü.; 0000-0003-0463-6818; K-7285-2012; 7004498001
The family of IL-10-related cytokines includes several human members, IL-19, IL-20, IL-22, IL-24 and IL-26, and a series of herpesviral and poxviral paralogs. Some of these cytokines share common receptor subunits. In this study, we investigated the effects of these cytokines on naive T cell differentiation, antigen-specific T cell suppression, survival and expression of surface markers in comparison to IL-10 and cytomegalovirus (CMV)-IL-10. Human CD45RA(+) T cells were stimulated in the presence of IL-10-family cytokines in sequential 12-day cycles. After three to four cycles of stimulation, IL-10 and CMV-IL-10 led to increased IFN-gamma and IL-10 but decreased IL-4 and IL-13. Interestingly, long-term exposure of T cells to IL-19, IL-20 and IL-22 down-regulated IFN-gamma but up-regulated IL-4 and IL-13 in T cells and supported the polarization of naive T cells toTh2-like cells. in contrast, neutralization of endogenous IL-22 activity by IL-22-binding protein decreased IL-4, IL-13 and IFN-gamma synthesis. The antigen-specific suppressor activity of IL-10 and CMV-IL-10 was not observed for any of the other IL-10-family cytokines. These data demonstrate that IL-19, IL-20 and IL-22 may participate in T cell-mediated diseases by distinct regulation of T cell cytokine profiles.
Regulatory cytokines TGF-beta and IL-10 as well as allergen-specific IgA and IgG4 play key role in tolerance to mucosal allergens in aormal immunity and specific immunotherapy
(Wiley, 2002-07) Jutel, Marek; Malolepszy, Jozef; Aebischer, Casaulta C.; Wrzyszcz, Maria; Blaser, Kurt; Budak, Ferah; Akdiş, Mübeccel; Akdis, Cezmi A.; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; 0000-0001-8020-019X; AAV-4844-2020; F-4657-2014