Browsing by Author "Birtane, Murat"
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Publication Attitudes of patients with spondylarthritis or rheumatoid arthritis regarding biological treatment during covid-19 pandemic: A multi-center, phone-based, cross-sectional study(Türkiye Romatizma Araştırma ve Savaş Derneği, 2021-12-01) Zateri, Coskun; Birtane, Murat; Aktaş, İlknur; Sarıkaya, Selda; Rezvani, Aylin; Altan, Lale; Dursun, Nigar; Dursun, Erbil; Taştekin, Nurettin; Çeliker, Reyhan; Özdolap, Şenay; Akgün, Kenan; ALTAN İNCEOĞLU, LALE; 0000-0002-7948-5383; 0000-0002-1050-9666; 0000-0002-8015-0513; 0000-0002-6552-7204; AAH-1652-2021Objectives: In this study, we aimed to investigate the medical treatment attitudes of patients with spondylarthritis or rheumatoid arthritis (RA) who were using biological drugs during the novel coronavirus-2019 (COVID-19) pandemic.Patients and methods: In this multi-center, cross-sectional study, a total of 277 patients (178 males, 99 females; median age: 45 years; range, 20 to 77 years) who were using biological disease-modifying anti-rheumatic drugs (bDMARDs) for rheumatic diseases and were reached by phone between June 1st, 2020 and June 30th, 2020 were included. Demographic characteristics, working status, type of the rheumatic disease, comorbidities, smoking habits, and type of the bDMARDs were recorded. Disease activity was evaluated using the Visual Analog Scale (VAS). The patients were asked whether they continued the treatment plan, as it was before or changed and, if changed, how they changed the plan and what happened after the change.Results: Of the patients, 229 had spondylarthritis and 48 had RA. A total of 36.1% of the patients were smokers, and the most common comorbidity was hypertension (17.3%). Totally, 5.8% of the patients had a history of contact with a COVID-19 positive person. Only three (1.1%) patients were diagnosed with COVID-19 infection and none of them died. Of the patients, 64.3% continued their treatment, while 35.7% adopted various changes. Most patients made the decision about the treatment plan on their own (n=160, 57.8%), while 38.3% of them consulted their physicians and 13.9% of them consulted any health staff. The only significant parameter for changing the drug course was receiving intravenous bDMARDs (by infusion at hospital) (p=0.001). These patients had also a higher disease activity as measured by VAS, compared to the patients receiving non-infusion therapy (p=0.021). As a result of these changes, severity of the symptoms increased in 91 (32.9%) patients. Disruption of regular biological treatment and prior infusion therapy more likely worsened the complaints (p<0.001 and p=0.024, respectively).Conclusion: Intravenous bDMARD therapy seems to be the main factor affecting the continuity of the treatment in the pandemic period. During the pandemic period, alternative treatment options should be considered other than infusion therapy not to interrupt the treatment of these patients.Item Quality of life and related variables in patients with ankylosing spondylitis(Springer, 2011-05) Bodur, Hatice; Ataman, Şebnem; Rezvani, Aylin; Buğdaycı, Derya Soy; Çevik, Remzi; Birtane, Murat; Akıncı, Ayşen; Altay, Zuhal; Günaydın, Rezzan; Yener, Mahmut; Koçyiğit, Hikmet; Duruöz, Tuncay; Yazgan, Pelin; Çakar, Engin; Aydın, Gülümser; Hepgüler, Simin; Kırnap, Mehmet; Ölmez, Neşe; Soydemir, Raikan; Kozanoğlu, Erkan; Bal, Ajda; Karkucak, Murat; Günendi, Zafer; Altan, Lale; Sivrioğlu, Koncuy; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; 56245687600; 6603281363To evaluate quality of life (QoL) and related variables in patients with ankylosing spondylitis (AS), a chronic inflammatory disease of the spine. Nine-hundred and sixty-two patients with AS from the Turkish League Against Rheumatism AS Registry, who fulfilled the modified New York criteria, were enrolled. The patients were evaluated using the Assessment of SpondyloArthritis International Society core outcome domains including Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), fatigue (BASDAI-question 1), pain (last week/spine/due to AS), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Radiology Index (BASRI), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) and two QoL questionnaires (the disease-specific ASQoL and generic the Short Form-36 [SF-36]). The mean ASQoL score was 7.1 +/- A 5.7. SF-36 subscales of general health, physical role and bodily pain had the poorest scores. ASQoL was strongly correlated with disease duration, BASDAI, fatigue, BASFI, BASMI, BASRI, MASES, pain and SF-36 subscales (P < 0.001). SF-36 subscales were also strongly correlated with BASDAI and BASFI. Advanced educational status and regular exercise habits positively affected QoL, while smoking negatively affected QoL. In patients with AS, the most significant variables associated with QoL were BASDAI, BASFI, fatigue and pain. ASQoL was noted to be a short, rapid and simple patient-reported outcome (PRO) instrument and strongly correlated with SF-36 subscales.Item Reliability and validity of Turkish version of fibromyalgia participation questionnaire(Bmj Publishing, 2017-06) Çeliker, Reyhan; Birtane, Murat; Akgün, Kenan; Zateri, Coşkun; Taştekin, Nurettin; Rezvani, Aylin; Aktaş, İlknur; Özdolap, Şenay; Altan, Lale; Ercan, İlker; Uludağ Üniversitesi/Tıp Fakültesi/Fizik Tedavi ve Rehabilitasyon Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi.; AAH-1652-2021; ABF-2367-2020Item Reliability and validity of Turkish version of the fibromyalgia rapid screening tool (FIRST)(Bmj Publishing Group, 2016-06) Çeliker, Reyhan; Rezvani, Aylin; Aktaş, İlknur; Taştekin, Nurettin; Dursun, Erbil; Dursun, Nigar; Sarıkaya, Sevda; Özdolap, Şenay; Akgün, Kenan; Zateri, Coşkun; Birtane, Murat; Altan, Lale; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; AAH-1652-2021Item Risk of falls in patients with ankylosing spondylitis(Lippincott Williams & Wilkins, 2015-03) Dursun, Nigar; Sarıkaya, Selda; Özdolap, Şenay; Dursun, Erbil; Zateri, Coşkun; Birtane, Murat; Akgün, Kenan; Revzani, Aylin; Aktaş, İlknur; Taştekin, Nurettin; Çeliker, Reyhan; Altan, Lale; Uludağ Üniversitesi/Tıp Fakültesi/Fizik Tedavi ve Rehabilitasyon Anabilim Dalı.; 0000-0002-6453-8382; AAH-1652-2021; 6603281363Background: Risk of vertebral fractures is increased in patients with ankylosing spondylitis (AS). The underlying mechanisms for the elevated fracture risk might be associated with bone and fall-related risks. The aims of this study were to evaluate the risk of falls and to determine the factors that increase the risk of falls in AS patients. Methods: Eighty-nine women, 217 men, a total of 306 AS patients with a mean age of 40.1 +/- 11.5 years from 9 different centers in Turkey were included in the study. Patients were questioned regarding history of falls within the last 1 year. Their demographics, disease characteristics including Bath AS Disease Activity Index, Bath AS Metrology Index (BASMI), Bath AS Functional Index (BASFI), and risk factors for falls were recorded. The Short Physical Performance Battery (SPPB) test was used for evaluation of static and dynamic balance. Erythrocyte sedimentation rate, C-reactive protein, and 25-hydroxyvitamin D levels were measured. Results: Forty of 306 patients reported at least 1 fall in the recent 1 year. The patients with history of falls had higher mean age and longer disease duration than did nonfallers (P = 0.001). In addition, these patients' BASMI and BASFI values were higher than those of nonfallers (P = 0.002; P = 0.000, respectively). We found that the patients with history of falls had lower SPPB scores (P = 0.000). We also found that the number of falls increased with longer disease duration and older age (R = 0.117 [P = 0.041] and R = 0.160 [P = 0.005]). Our results show that decreased SPPB scores were associated with increased number of falls (R = 0.183, P = 0.006). Statistically significant correlations were found between number of falls and AS-related lost job (R = 0.140, P = 0.014), fear of falling (R = 0.316, P = 0.000), hip involvement (R = 0.112, P = 0.05), BASMI (R = 0.234, P = 0.000), and BASFI (R = 0.244, P = 0.000). Conclusions: Assessment of pain, stiffness, fatigue, and lower-extremity involvement as well as asking for a history of falls will highlight those at high risk for further falls. In addition to the general exercise program adopted for all patients, we suggest that a balance rehabilitation program should be valuable for the patients with risk factors for fall. Exercise may improve fear of falling and BASFI and BASMI scores. However, further study is needed to investigate these hypotheses. We believe that clinicians should train and support the patients via reducing fear of falls and maintaining good posture and functional capacity.Item Turkish league against rheumatism national recommendations for the management of ankylosing spondylitis(Romatizmaya Karşı Türk Dili Yayınları, 2011) Bodur, Hatice; Sivas, Filiz; Yılmaz, Özlem; Özgöçmen, Salih; Günaydın, Rezzan; Kaya, Tacıser; Ataman, Şebnem; Altay, Zuhal; Aydoğ, Ece; Birtane, Murat; Borman, Pınar; Buğdaycı, Derya Soy; Bütün, Bülent; Çakırbay, Haşim; Duruöz, Tuncay; Gürer, Gülcan; Hepgüler, Simin; Kamanlı, Ayhan; Kuru, Ömer; Küçükdeveci, Ayşe; Nacir, Barış; Ölmez, Neşe; Rezvani, Aylin; Yanık, Burcu Çörekçi; Altan, Lale; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; AAH-1652-2021; 6603281363Objectives: To develop Turkish League Against Rheumatism (TLAR) National Recommendations for the management of ankylosing spondylitis (AS). Materials and methods: A scientific committee of 25 experts consisting of six rheumatologists and 19 physical medicine and rehabilitation specialists was formed by TLAR. Recommendations were based on the 2006 ASsessment in Ankylosing Spondylitis International Working Group(ASAS)/European League Against Rheumatism (EULAR) recommendations and a systematic review of associated publications between January 2005 and September 2010. A Delphi process was used to develop the recommendations. Twelve major recommendations were constructed for the management of AS. Voting using a numerical rating scale assessed the strength of each recommendation. Results: The 12 recommendations include patient assessment, patient follow-up along with pharmacological and non-pharmacological methods. Some minor additions and changes have been made to the ASAS/EULAR recommendations. All of the recommendations had sufficient strength. Conclusion: National recommendations for the management of AS were developed based on scientific evidence and consensus expert opinion. These recommendations will be updated regularly in accordance with recent developments.