Browsing by Author "Aymak, Figen"

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IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis
(Academic Press, 2007-04) Baştürk, Bilkay; Budak, Ferah; Göral, Güher; Heper, Yasemin; Yılmaz, Emel; Aymak, Figen; Töre, Okan; Ener, Beyza; Oral, Haluk B.; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Anabilim Dalı.; 0000-0003-0463-6818; 0000-0002-4803-8206; 0000-0002-3894-1231; AAH-6506-2021; AAG-8523-2021; K-7285-2012; F-4657-2014; A-5841-2017; 6701913697; 6603453166; 56191003300; 22037135100; 16645073100; 6505909596; 15053025300; 7004498001
Several genes encoding for different cytokines may play crucial roles in host susceptibility to Brucellosis, since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphism. The association of the cytokine gene polymorphisms with the development of Brucellosis was investigated in this study. DNA samples were obtained from a Turkish population of 40 patients with Brucellosis, and 50 healthy control subjects. All genotyping (IL-6, IL10, IFN-γ, TGF-β and TNF-α) experiments were performed using sequence-specific primers PCR (PCR-SSP). When compared to the healthy controls, the frequencies of high/intermediate producing genotypes of IL-10 and high producing genotype of IL-6 were significantly more common in the patient group. These results suggest that IL-10 and IL-6 gene polymorphisms may affect susceptibility to Brucellosis and increase risk of developing the disease. In order to confirm the biological significance of our results, further studies should be performed in larger population groups.
The involvement of IL-10, IL-6, IFN-gamma, TNF-alpha and TGF-beta gene polymorphisms among Turkish lung cancer patients
(Wiley, 2008-04) Baştürk, Bilkay; Çolakoğulları, Mukaddes; Ulukaya, Engin; Oral, Arzu Yılmaztepe; Aymak, Figen; Ursavaş, Ahmet; Oral, Haluk Barbaros; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.; 0000-0003-0463-6818; 0000-0003-0463-6818; A-5841-2017; K-7285-2012; K-5792-2018; AAI-3169-2021; 14423975800; 6602927353; 23091316500; 16645073100; 8329319900; 16645073100
Several genes encoding different cytokines may play crucial roles in host susceptibility to lung cancer, since cytokine production capacity varies among individuals and depends on cytokine gene polymorphisms. The association between cytokine gene polymorphisms with primary lung carcinoma was investigated. DNA samples were obtained from a Turkish population of 44 patients with primary lung cancer, and 59 healthy control subjects. All genotyping (IFN-gamma, TGF-beta 1, TNF-alpha, IL-6 and IL-10) experiments were performed using sequence-specific primers (SSP)-PCR. When compared to the healthy controls, the frequencies of high/intermediate producing genotypes of IL-10 and low producing genotype of TNF-a were significantly more common in the patient group. It is noteworthy that lung cancer patients with the TGF-beta T/T genotype in codon 10 had statistically longer survival compared to those having the C/C genotype (Kaplan-Meier survival function test, log rank significance = 0.014). These results suggest that IL-10, TNF-alpha and TGF-beta 1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients.
Prevalence of HLA-B*57 serotype associated with hypersensitivity reaction in HIV treatment in Turkish population
(Wiley, 2021-08-01) Kızmaz, Muhammed Ali; Aymak, Figen; Oral, Haluk Barbaros; Budak, Ferah; Kızmaz, Muhammed Ali; Aymak, Figen; ORAL, HALUK BARBAROS; BUDAK, FERAH; Bursa Uludağm Üniversitesi/Tıp Fakültesi/İmminoloji Anabilim Dalı.; 0000-0001-5334-7911; 0000-0003-0463-6818; 0000-0001-7625-9148; F-4657-2014; K-7285-2012; IZP-9398-2023; HKN-2347-2023
The prevalence of hla-b*57 serotype associated with hypersensitivity reactions in the treatment of hiv i̇nfection in the Turkish population
(Bentham Science, 2023-01-01) Kizmaz, Muhammed Ali; Simsek, Abdurrahman; ŞİMŞEK, ABDURRAHMAN; Aymak, Figen; Akalin, Emin Halis; AKALIN, EMİN HALİS; Budak, Ferah; BUDAK, FERAH; Oral, Haluk Barbaros; ORAL, HALUK BARBAROS; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Immunoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0001-5334-7911; 0000-0001-8850-0269; 0000-0001-7530-1279; 0000-0003-0463-6818; 0000-0001-7625-9148; HKN-2347-2023; K-7285-2012
Objectives The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish population and to provide new perspectives to physicians starting abacavir therapy in HIV patients.Background Abacavir, one of the drugs used to treat HIV infection, can cause hypersensitivity reactions in some patients. These hypersensitivity reactions have been shown to be associated with the HLA-B*57:01 allele. High-resolution HLA-B*57:01 scanning has a time and cost disadvantage compared with low-resolution HLA-B*57 scanning. Before starting abacavir treatment, we will discuss whether high-resolution scanning is more beneficial in individuals who are positive on HLA-B*57 screening. This is the study with the largest cohort to investigate the prevalence of HLA-B*57 in Turkey.Methods The results of 25 thousand 318 people who applied to Bursa Uludag University Faculty of Medicine, Department of Immunology for HLA-B* typing were scanned.Results In our study, the HLA-B*57 serotype was detected in 827 (3.3%) individuals.Conclusion Considering these results, it can be assumed that the prevalence of HLA-B*57:01 in Turkey is lower than 3.3%. Instead of a high-resolution HLA-B*57:01 scan in all patients starting abacavir therapy, a high-resolution HLA-B*57:01 scan might be of greater benefit in patients who are positive on a low-resolution HLA-B*57 scan.