Browsing by Author "Ayaz, Erol"

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Anthelmintic activity of urtica dioica L. in mice naturally infected with Aspiculuris tetraptera
(Medwell Online, 2008-12-01) Türel, İdris; Oto, Gökhan; Ayaz, Erol; Yılmaz, Orhan; Mercan, Ufuk; Ayaz, Erol; Uludağ Üniversitesi/Yenişehir İbrahim Orhan Meslek Yüksekokulu.; CED-1767-2022
The aim of present study was to investigate the anthelmintic activity of Urtica dioica L. (nettle) in Swiss albino mice naturally infected with Aspiculuris tetraptera. Methanolic extracts obtained from leaves and seeds of U dioica were evaluated for their in vivo anthelmintic activity. The 250 mu L (175 mg mL(-1)) extracts were administered orally on daily basis. Results showed that methanolic extract of U. dioica seeds possessed only a slight anthelmintic activity. In contrast, methanolic extract of leaves exhibited potent anthelmintic activity.
Antimicrobial effect of garlic (Allium sativum) and traditional medicine
(Medwell Online, 2010-01) Goncagül, Gülen; Ayaz, Erol; Uludağ Üniversitesi/Yenişehir İbrahim Orhan Meslek Yüksekokulu.; AAK-6555-2021; 8350555500; 23048475600
Medicinal plants like pumpkin seed, thyme, onion, nigella sativa, lemon balm, stinging nettle are used extensively today. One of these plants used most intensively and widespread is garlic. In this context, fresh shape, powder state and oil of garlic have been used all around the world especially in Far East for centuries. In conclusion it is observed that the information transferred between generations and studies made scientifically that garlic is effectively used in cardiovascular diseases as regulator of blood pressure and with dropper effects of it on glycaemia and cholesterol, against bacterial, viral, mycosis and parasitic infections. It's also known that garlic is a wonderful plant having the properties of empowering immune system, anti-tumour and antioxidant. Garlic shows its this effect thanks to >200 components it involves. Garlic includes to >200 components such as volatile oils (allicin, alliin and ajoene) consisting of sulphur, enzymes (alliinase, peroxidase and miracynase), carbohydrates (sucrose, glucose), minerals (germanium, selenium, zinc), amino acids like cysteine, glutamine, isoleucine and methionine, bioflavonoids like quercetin and cyanidin and allistatin I and allistatin II, C, E and A vitamins and niacin, B-1,B- B-2 vitamins and beta carotene. In this study, it will be given a summary about properties of garlic and its areas of use against bacterial diseases.
Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats
(BMC, 2015-12-12) Aksit, Dilek; Yalinkilinc, Hande Sultan; Sekkin, Selim; Boyacioglu, Murat; Ayaz, Erol; Gokbulut, Cengiz; Cirak, Veli Yilgor; Uludağ Üniversitesi/Veteriner Fakültesi/Klinik Öncesi Bilimler Bölümü.; 0000-0003-0570-2514; FYC-2043-2022; 6602404057
Background: The aims of this study were to compare the pharmacokinetics of albendazole sulfoxide (ABZ-SO, ricobendazole) in goats and sheep at a dose of 5 mg/kg bodyweight (BW), after intravenous (IV) and subcutaneous (SC) administrations, and to investigate the effects of increased doses (10 and 15 mg/kg BW) on the plasma disposition of ABZ-SO in goats following SC administration. A total of 16 goats (Capra aegagrus hircus, eight males and eight females) and 8 sheep (Ovis aries, four males and four females) 12-16 months old and weighing 20-32 kg, were used. The study was designed according to two-phase crossover study protocol. In Phase-1, eight sheep were assigned as Group I and 16 goats were allocated into two groups (Group II and Group III). ABZ-SO was applied to Group I (sheep) and Group II (goats) animals subcutaneously, and to Group III (goats) animals intravenously, all at a dose rate of 5 mg/kg BW. In Phase-2, the sheep in the Group I received ABZ-SO intravenously in a dose of 5 mg/kg BW; the goats in Group II and Group III received ABZ-SO subcutaneously at a dose of 10 mg/kg and 15 mg/kg BW, respectively. Blood samples were collected from the jugular vein at different times between 1 and 120 h after drug administrations. The plasma concentrations of ABZ-SO and its metabolites were analysed by high performance liquid chromatography. Results: In goats, the area under the curve, terminal half-life and plasma persistence of ABZ-SO were significantly smaller and shorter, respectively, compared with those observed in sheep following both IV and SC administrations at a dose of 5 mg/kg BW. On the other side, dose-dependent plasma dispositions of ABZ-SO were observed following SC administration at increased doses (10 and 15 mg/kg) in goats. Conclusions: Consequently, ABZ-SO might be used at higher doses to provide higher plasma concentration and thus to achieve greater efficacy against the target parasites.
The effect of Nigella sativa oil against Aspiculuris tetraptera and Hymenolepis nana in naturally infected mice
(Saudi Medical Journal, 2007-11) Yılmaz, Hasan; Özbek, Hanefi; Taş, Zeynep; Orunç, Özlem; Ayaz, Erol; Uludağ Üniversitesi/Yenişehir İbrahim Orhan Meslek Yüksekokulu.; 23048475600
Objectives: To investigate the antiparasitic effect of Nigella sativa oil (NSO) on Aspiculuris tetraptera (A. tetraptera) and Hymenolepis nana (H.nana) in mice in January 2005. Methods: Mice were obtained from the animal house facility of the Faculty of Medicine, Yuzuncu Yil University, Van, Turkey. The natural infections were determined by the cellophane tape method and the centrifugal flotation method of stool samples. The infected mice with A. tetraptera and H. nana were divided into 4 groups; 2 treatment and 2 control groups. Nigella sativa oil was given at the dose of 250 mu l/kg body weight orally for 2 consecutive days in the 2 treatment groups. All the mice were sacrificed on the seventh day after the last treatment. Gastrointestinal tract of the sacrificed animals was opened and washed with a serum physiologic. The contents were examined under a stereo microscope for counting and identifying of the parasites. The treatment and the control groups were compared using Mann-Whitney U-Test. Results: Nigella sativa oil reduced both A. tetraptera and its eggs. The difference was significant between Group 1 and Group 3 (p < 0.05). Nigella sativa oil reduced H.nana eggs starting from second day of the treatment until necropsy day during 5 days, but it was not significant between Group 2 and Group 4 (p > 0.05). Conclusions: Antiparasitic effect of NSO is related to its stimulating immune system.
In vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goats
(Wiley, 2021-04-24) Gökbulut, Cengiz; Çırak, Veli Y.; Aypak, Süleyman; Avcı, Hamdi; Sekkin, Selim; Yalınkılınç, Hande S.; Boğa, Buket; Ayaz, Erol; ÇIRAK, VELİ YILGÖR; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Parazitoloji Anabilim Dalı.; FYC-2043-2022
Sheep and goats are sharing different helminth parasites including Haemonchus contortus. Control of these helminths is based mainly on the use of anthelmintics. However, in goats, the application of anthelmintics is often carried out mainly at dosages determined for sheep without knowing the real effects and metabolism features. One of the several anthelmintic classes used against these parasites is (pro) benzimidazoles which are still widely in use in small ruminants in many countries. The objective of this study was to determine (i) the correlation between plasma and tissue or gastrointestinal content dispositions of ricobendazole (RBZ) in goats and (ii) the in vivo exposure of ricobendazole by H. contortus. Ten goats were experimentally infected with 10,000 larvae of H. contortus. Four weeks of post-infection, the animals received RBZ subcutaneously at 5 mg/kg body weight. Two goats were sacrificed per time at 1, 2, 4, 6 and 12 h after drug administration and, blood, bile, urine, liver, lung, muscle and kidney gastrointestinal tissues/fluids were collected. Adult H. contortus were collected from abomasum, and all samples were analysed by HPLC system. Ricobendazole (RBZ) and its sulphone metabolite were extensively excreted by urine and distributed to all tissues and digestive tract, mainly into the abomasum fluid. RBZ concentration in the lung and ABZSO(2) in the kidney were relatively higher than those of other tissues, respectively. The parent drug and its metabolite were recovered in both male and female H. contortus. This study indicates that in goats the plasma concentration profiles of RBZ are strongly correlated with those achieved in different target tissues or fluids, which in turn, reflect the amount of drug taken up by parasites.