Browsing by Author "Aslan, Vildan"
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Item Akciğer lobu kama (wedge) rezeksiyonundanon-kontakt diyod lazer uygulamalarının anlık ve postoperatif erken dönem sonuçlarının araştırılması(Bursa Uludağ Üniversitesi, 2022-07-18) Aslan, Vildan; Salcı, Hakan; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; 0000-0001-5323-6891Bu çalışmada, akciğer lobu kama (wedge) rezeksiyonunda non-kontakt 980 nm diyod lazerin anlık ve postoperatif erken dönemdeki radyolojik, laboratuvar ve histopatolojik bulgularının araştırılması amaçlandı. Çalışmada Yeni Zelanda ırkı tavşan kullanıldı ve (n=21) 3 gruba (n=7) ayrıldı. Sol torakotomi sonrası cranial akciğer lobunda, grup I'de (GRI) 15 watt/cm2, grup II'de (GRII) 10 watt/cm2 ve grup III'te (GRIII) 5 watt/cm2 güç yoğunluğu kullanılarak kama rezeksiyon yapıldı. Preoperatif ve postoperatif 0, 1, 7 ve 15. günlerde klinik ve radyolojik muayeneler ile preoperatif, 1, 7 ve 15. günlerde hematolojik, biyobelirteç, kan gazı analizleri yapıldı. Tavşanlar 0. gün ve sakrifiye edildikten sonra 15. günde alınan akciğer doku örneklerinin histopatolojisi incelendi. Verilere istatistik uygulandı. Respirasyon'un GRI'de postoperatif süreçte arttığı gözlendi ve 0. günde GRII ile GRI ve GRIII arasında (p=0,009, p<0,001) fark anlamlıydı. WBC, Neu, Eos, Bas, PLT değerleri tüm grup ve zamanlarda referans aralığındaydı. IL-1β, GRI ve GRIII'te 15. günde artarken, istatistiksel olarak anlamlı değildi (p>0,05). IL-8 değeri GRII'de postoperatif süreçte artarken, ölçüm zamanlarına göre preoperatif ile 1. gün (p=0,006) ve 1 ile 7. gün arasındaki (p=0,018) fark anlamlıydı. VEGF değerinin diğer gruplara göre GRII'de 1. günde artarak 15. günde hafif oranda azaldığı görülürken, 15. günde anlamlı farklılık GRI ve GRII arasında saptandı (p=0,013). PCO2, GRI'de 1. gün, PO2, GRI'de 1, 7, 15. gün ve SaO2 GRI'de 1 ve 7. günde referans değer üzerindeydi. GRII'de PO2 için, preoperatif ve 1. gün arasında (p=0,026) fark anlamlıydı. Akciğer deseni yönünden anlamlı farklılık, 1. günde GRI ile GRIII (p=0,03) ve GRII ile GRIII (p=0,018) arasında belirlendi. Karbonizasyon zonu için GRI ile GRIII ve GRII ile GRIII arasında (p=0,011, p=0,004), koagulasyon zonu için GRI ile GRII arasında (p=0,019) anlamlı farklılık saptandı. Fibroplazi miktarı için 15. günde GRI ile GRIII ve GRII ile GRIII (p=0,015, p=0,002) arasındaki fark anlamlıydı. Sonuç olarak; anlık ve erken postoperatif dönemdeki bulgular değerlendirildiğinde, akciğer dokusunun anatomik ve fizyolojik yapısını koruyacak en etkin lazer modunun, 980 nm dalga boyu, 15watt/cm2, non-kontakt mod, ortalama 60 sn süre ve 900 joule olduğu söylenebilir.Item Erkek bir köpekte meme bezinde anaplastik karsinoma olgusu(Uludağ Üniversitesi, 2017-12-25) Aslan, Vildan; Çeşme, Hilal; Mutlu, Ayşe Meriç; Cangül, İ. Taci; Salcı, Hakan; Uludağ Üniversitesi/Veteriner Fakültesi.Dokuz yaşlı, erkek, Rottweiler ırkı bir köpek, sağ ikinci torakal meme lobunda büyüme şikayetiyle kliniklerimize getirildi. Klinik olarak sağ torakal 2. papilla mamma yaklaşık 5x4×3 cm boyutlarında, ostium papillare ise ülseratif ve enfekteydi. Toraksın radyografisinde metastazı ortaya koyacak herhangi bir bulguya rastlanmadı. Ultrasonografik muayenede meme dokusu heterojen bir görünüme sahipti ve hiperekoik bir alan ile çevriliydi. Genel anestezi altında ilgili meme lobunun mastektomisi gerçekleştirildi. Histopatolojik incelemede meme bezi epitel hücrelerinin yer yer solid ve papiller tarzda ürediği ve hücrelerde mitotik aktivitenin oldukça yüksek olduğu gözlendi. Bu bulgulara dayanarak kitleye anaplastik karsinoma tanısı konuldu. Erkek köpeklerde nadir olarak gözlenen anaplastik meme bezi karsinoması bu olgu sunumu ile rapor edilmektedir.Item Histologic and electromyographic evaluation of neuroregenerative effect of stromal vascular fraction following neuroanastomosis(Kafkas Üniversitesi, 2020-03-23) Acar, Hilal; Çerçi, Ece; Khezri, Marzieh Karimi; Çetin, Melike; Canatan, Uygur; Şen, Mehmet Metin; Aslan, Vildan; Sarıl, Canan Altıncı; Temiz, Elif Mekik; Taşkapılıoğlu, Mevlüt Özgür; Erdost, Hatice; Salcı, Hakan; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.; 0000-0001-5472-9065; 0000-0003-0154-9938; 0000-0001-9650-0891; 0000-0001-5323-6891; 000-0003-1547-7293; 0000-0001-6548-8754; AAH-9216-2021; AAI-6861-2021; AAW-5254-2020; ABB-8161-2020; 57209653860; 57212212053; 57216947212; 56393942900; 57189443508; 57216950078; 57200994296; 57216954758; 57216945905; 25936798300; 6505787570; 8680329000In this study, histologic and electromyographic (EMG) evaluation of neuroregenerative effect of stromal vascular fraction (SVF) following periferal nerve anastomosis was aimed. Totally, 31 Wistar Albino, male rats (weighing about 300 g) were studied, and these rats were grouped according to surgical techniques performed on the right sciatic nerve: group I (GRI) micro suture (n=7), group II (GRII) micro suture + SVF (n=7), group III (GRIII) fibrin glue (n=7) and group IV (GRIV) fibrin glue + SVF (n=7). Fat tissue was taken from 3 rats to prepare SVF, and SVF was produced by non-enzymatic method. The left sciatic nerve of all rats was evaluated for EMG as control. Under general anesthesia, after transversal incision of the sciatic nerve, microsurgical epineural repair technique was performed with 10/0 nonabsorbable suture. EMG examinations were performed in terms of conduction rate, amplitude, distal latency and spontaneous muscle activity at 0th day and postoperative (PO) 1st and 8th weeks. EMG results between and within the groups were statistically evaluated by one-way analysis of variance. Rats in all groups were sacrificed by decapitation at PO 8th week and histological examinations of the sciatic nerves were performed following preparation of the neural tissues. EMG examination results showed the highest nerve conduction in GRI, the highest amplitude in GRIII, normal latency in GRII and longer distal latency in GRIV at PO 8th week. Amplitude and conduction velocity increased gradually in all groups. In needle EMG, the best muscle membrane stabilization was achieved in GRII and GRIV at PO 8th week. Statistically, the values of amplitude, distal latency, conduction velocity, and spontaneous muscle activity were found to be at normal levels at PO 8th week in all groups (P>0.05). In the histological results, although fibroconnective tissue reactions in the anastomosis area had similar scores in GRII and GRIV, maximum fibroconnective tissue reaction and the best axonal regeneration was seen in GRI and GRIII, respectively. In addition, GRI and GRII had the most inflammatory cells accumulation in the suture region, and less inflammatory cells were seen in the anastomosis area of GRIII and GRIV. As a conclusion, fibrin glue presents good electrophysiological and histological results; however, it is clear that local SVF usage on the nerve anastomosis area can be a good choice to decrease fibroconnective tissue reaction and inflammation.Publication How effective is individual claw trimming in cattle? An ex-vivo study(Sivar-soc Italiana Veterinari Animali Reddito, 2021-02-01) Canatan, Uygur; Akbala, Melike; Akbala, Melike; Cetin, Melike; Acar, Hilal; ACAR, HİLAL; Aslan, Vildan; ASLAN, VİLDAN; Saril, Canan Altinci; Temiz, Elif Mekik; Yigitgor, Pelin; Salci, Hakan; SALCI, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.; JDC-5958-2023; JPN-6878-2023Claw trimming is an application to give a functional shape to the claws, to maintain foot weight distribution and to prevent foot diseases. Claw trimming should be done by experts. In this study, it was aimed to show the effectiveness of individual claw trimming applied in cattle claws by morphometric measurements.As material, 85 ex-vivo cattle feet of different races were used. The feet were divided into four groups as right front (n=17), left front (n=17), right hind (n=24) and left hind (n=27). In addition, the claws were divided laterally and medially. After the mechanical cleaning of the claws, functional nail cutting (Dutch method) was applied by different people and morphometric measurements of the claws (claw angle, dorsal wall length, claw height, diagonal length, heel height, inner heel height, sole length, sole width, abaxial white line width and axial white line width).The claw angle was 49 degrees on the right hind lateral, 47 degrees on the right hind medial, 49 degrees on the left hind medial and within reference ranges on the other claws. Statistically, dorsal wall length of right anterior lateral (p=0.006) and left posterior medial (p=0.01) claws were significant. Significance was also detected left posterior lateral (p=0.01) and left posterior medial (p=0.01) claws in diagonal length. Inner heel height was significant on claws of left posterior lateral (p=0.01), and there was significant difference on right front lateral (p=0.02), left anterior medial (p=0.03) and left posterior medial (p=0.002) claws in terms of sole width. A positive correlation was found in the correlation analysis between all parameters except claw angle.As a conclusion, the claw trimming is important manipulation in large animal practice, regardless of the applied claw trimming technique, individual claw trimming has some difference on morphometric shape of the claws, and it should be performed by masters on this.Item Tracheobronchoscopic, cytological and microbiological results of tracheal and bronchial collapse in dogs(Polish Soc Veterinary Sciences Editorial Office, 2017-07-31) Salcı, Hakan; Çetin, Melike; Kahya, Serpil; Akkoç, Ahmet; Yılmaz, Özge; Canatan, Uygur; Çeşme, Hilal; Aslan, Vildan; Altıncı, Canan; Khider, Mohammed; Yılmaz, Zeki; Bayram, Ahmet Sami; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0001-9836-0749; 0000-0003-0684-0900; 0000-0002-6227-1098; AAI-6861-2021; AAH-2842-2021; AAG-7421-2021; T-4623-2019; A-9637-2008; ABB-7580-2020; 8680329000; 56393942900; 35368679200; 55584229300; 56524019400; 57189443508; 56951171800; 57200994296; 57200984827; 57200991560; 35944810500; 8347194000The aim of this study was to evaluate the tracheobronchoscopic, cytological and microbiological results of tracheal and bronchial collapse in dogs. In total, 8 dogs were included in the study. Clinically, tracheal palpations of the dogs were reflective of tracheal disease, and all dogs coughed on tracheal palpation. Vital parameters and hematological values of the dogs were within the normal ranges. Radiological views of the respiratory tracts and thorax were largely normal, but distinctive tracheal contours were noted in cases 3 and 6. Tracheobronchoscopy was performed under general anesthesia, and endoscopic findings (mucosal surfaces and color, prominent appearance of vessels, chondral ring abnormalities of the trachea, and the presence of bronchial and tracheal collapse) were scored. Bronchoalveolar lavage (BAL) was performed to collect samples for cytological and microbiological analysis. Five cases had tracheal collapse, and two cases had right bronchial collapse. Concurrent tracheal and right bronchial collapse were diagnosed in one case. Cytological results were not indicative of inflammation or infection, but Escherichia coli was isolated from case 2 (bronchial collapse) and case 3 (tracheal collapse). Antibiotic susceptibility results revealed that the organisms were susceptible to sulfamethoxazole/trimethoprim. Statistically, there were no significant differences between the cases in terms of total endoscopic scores. In conclusion, tracheal and/or bronchial collapse should only be diagnosed by tracheobronchoscopic examination. Cytological and microbiological analyses of the BAL fluid in these cases do not always provide valuable data for clinical practitioners.