Browsing by Author "Akdis, Cezmi A."

Now showing 1 - 3 of 3

Effect of altered human exposome on the skin and mucosal epithelial barrier integrity
(Taylor & Francis Inc, 2022-10-21) Pat, Yagiz; Oğulur, İsmail; Yazici, Duygu; Mitamura, Yasutaka; Cevhertaş, Laçin; Kucukkase, Ozan C.; Mesisser, Sanne S.; Akdis, Mubeccel; Nadeau, Kari; Akdis, Cezmi A.; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Tıbbi İmmünoloji Anabilim Dalı.; FYD-1431-2022
Pollution in the world and exposure of humans and nature to toxic substances is continuously worsening at a rapid pace. In the last 60 years, human and domestic animal health has been challenged by continuous exposure to toxic substances and pollutants because of uncontrolled growth, modernization, and industrialization. More than 350,000 new chemicals have been introduced to our lives, mostly without any reasonable control of their health effects and toxicity. A plethora of studies show exposure to these harmful substances during this period with their implications on the skin and mucosal epithelial barrier and increasing prevalence of allergic and autoimmune diseases in the context of the "epithelial barrier hypothesis". Exposure to these substances causes an epithelial injury with peri-epithelial inflammation, microbial dysbiosis and bacterial translocation to sub-epithelial areas, and immune response to dysbiotic bacteria. Here, we provide scientific evidence on the altered human exposome and its impact on epithelial barriers.
IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
(Wiley, 2003-02-19) Jutel, Marek; Akdis, M.; Aebischer-Casaulta, C.; Wrzyszcz, Maria; Blaser, Kim M.; Akdis, Cezmi A.; Budak, Ferah; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; F-4657-2014
The regulation of normal and allergic immune responses to airborne allergens in the mucosa is still poorly understood, and the mechanism of specific immunotherapy (SIT) in normalizing the allergic response to such allergens is currently not clear. Accordingly, we have investigated the immunoregulatory mechanism of both normal and allergic responses to the major house-dust mite (HDM) and birch pollen allergens - Dermatophagoides pteroynyssinus (Der p)1 and Bet v 1, respectively - as well as the immunologic basis of SIT to HDM in rhinitis and asthma patients. In normal immunity to HDM and birch pollen, an allergen-specific peripheral T cell suppression to Der p 1 and Bet v 1 was observed. The deviated immune response was characterized by suppressed proliferative T cell and Th1 (IFN-gamma) and Th2 (IL-5, IL-13) cytokine responses, and increased IL-10 and TGF-beta secretion by allergen-specific T cells. Neutralization of cytokine activity showed that T cell suppression was induced by IL-10 and TGF-beta during SIT and in normal immunity to the mucosal allergens. In addition, SIT induced an antigen-specific suppressive activity in CD4(+) CD25(+) T cells of allergic individuals. Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens.
Regulatory cytokines TGF-beta and IL-10 as well as allergen-specific IgA and IgG4 play key role in tolerance to mucosal allergens in aormal immunity and specific immunotherapy
(Wiley, 2002-07) Jutel, Marek; Malolepszy, Jozef; Aebischer, Casaulta C.; Wrzyszcz, Maria; Blaser, Kurt; Budak, Ferah; Akdiş, Mübeccel; Akdis, Cezmi A.; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; 0000-0001-8020-019X; AAV-4844-2020; F-4657-2014