Browsing by Author "Akdiş, Mübeccel"

Now showing 1 - 9 of 9

Atopik dermatit'in patogenezinde immunolojik mekanizmalar
(Uludağ Üniversitesi, 2004) Akdiş, Mübeccel; Akdiş, Cezmi A.
Aktive T-hücreleri ve ürünleri, psöriasis ve atopik dermatit (AD) gibi birçok cilt hastalığının patogenezinde önemli bir rol oynarlar. Aktivasyonu takiben, periferik kandaki T hücrelerinin derideki selektif yerleşimi ve efektör işlevleri, patogenezdeki immunolojik olaylar dizinini temsil eder. Kutanöz lenfositle ilişkili antijen (CLA), bellek/efektör T hücresinin deriye migrasyonunda rol oynayan bir yerleşim reseptörüdür. CLA, farklılaşma sürecinde Th1 hücreleri üzerinde belirir ve Th2 hücreleri üzerinde de bakteriyel super antigen ve/veya IL-12 uyarısıyla indüklenebilir. Muhtemelen, deriye özgü yerleşim, işlevsel ve fenotipik T hücre subsetleri ile sı- nırlı değildir. Bazı T hücre reseptörlerinde değişken β zinciri ekspresyonu veya IL-12Rβ ekspresyonu ile karakterize IL-12 ve/veya süperantijen yanıtı, T hücreleri üzerindeki CLA ekspresyonunu kontrol eden faktörlerdir. CLA taşıyan CD4 ve CD8 T hücreleri, AD hastalarının periferik kanındaki aktive bellek/efektör T hücre subsetlerini temsil eder. Bunlar, IgE’yi IL-13 aracılığıyla uyarırlar ve eosinofil yaşam süresini de IL-5 aracılığıyla uzatırlar. Atopik hastalıklardaki periferik Th2 yanıtının bir mekanizması olarak, dolaşımdaki aktive bellek/efektör Th1 hücreleri selektif olarak aktivasyon ile indüklenen hücre ölümüne uğrayarak, immün yanıtı hayatta kalan Th2 hücrelerinden yana kaydırır. Atopik dermatitde, T hücreleri, dendritik hücreler ve keratinositlerden oluşan bir kemokin ağı, inşamatuvar hücrelerin deriye infiltrasyonunu kontrol eder. Aktive olan bu T hücreleri, Fas bağımlı bir yol ile keratinosit apoptozisini indükler ki bu spongiosis ve ekzematöz lezyonların oluşumunda önemli bir patogenetik faktördür.
B regulatory cells in allergy
(Wiley, 2020-12-21) Ma, Siyuan; Satitsuksanoa, Pattraporn; Jansen, Kirstin; Van de Veen, Willem; Akdiş, Mübeccel; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; 0000-0003-2287-3569; 57216918051
B cells have classically been recognized for their unique and indispensable role in the production of antibodies. Their potential as immunoregulatory cells with anti-inflammatory functions has received increasing attention during the last two decades. Herein, we highlight pioneering studies in the field of regulatory B cell (Breg) research. We will review the literature on Bregs with a particular focus on their role in the regulation of allergic inflammation.
Dysregulation of the epithelial barrier by environmental and other exogenous factors
(Wiley, 2021-08-18) Mitamura, Yasutaka; Öğülür, İsmail; Pat, Yağız; Rinaldi, Arturo O.; Ardıçlı, Özge; Cevhertaş, Laçin; Brueggen, Marie-Charlotte; Traidl-Hoffmann, Claudia; Akdiş, Mübeccel; Akdiş, Cezmi A.; ARDIÇLI, ÖZGE; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Tıbbi İmmünoloji Anabilim Dalı.; AAG-7421-2021; FYD-1431-2022
The "epithelial barrier hypothesis" proposes that the exposure to various epithelial barrier-damaging agents linked to industrialization and urbanization underlies the increase in allergic diseases. The epithelial barrier constitutes the first line of physical, chemical, and immunological defense against environmental factors. Recent reports have shown that industrial products disrupt the epithelial barriers. Innate and adaptive immune responses play an important role in epithelial barrier damage. In addition, recent studies suggest that epithelial barrier dysfunction plays an essential role in the pathogenesis of the atopic march by allergen sensitization through the transcutaneous route. It is evident that external factors interact with the immune system, triggering a cascade of complex reactions that damage the epithelial barrier. Epigenetic and microbiome changes modulate the integrity of the epithelial barrier. Robust and simple measurements of the skin barrier dysfunction at the point-of-care are of significant value as a biomarker, as recently reported using electrical impedance spectroscopy to directly measure barrier defects. Understanding epithelial barrier dysfunction and its mechanism is key to developing novel strategies for the prevention and treatment of allergic diseases. The aim of this review is to summarize recent studies on the pathophysiological mechanisms triggered by environmental factors that contribute to the dysregulation of epithelial barrier function.
IL-10 and TGF- beta cooperate in inducing peripheral T cell tolerance during specific immunotherapy with inhalant allergens and during natural allergen exposure
(Mosby Elsevier, 2001-02) Jutel, Marek; Malolepszy, Josef; Casaulta, Carmen; Wrzyszcz, Maria; Blaser, Kurt; Budak, Ferah; Akdiş, Mübeccel; Akdis, Cezmi; Uludağ Üniversitesi/Tıp Fakültesi/Klinik Immunoloji Anabilim Dalı.; 0000-0001-8020-019X; F-4657-2014; AAV-4844-2020
Innate lymphoid cell subsets in obese asthma patients: Difference in activated cells in peripheral blood and their relationship to disease severity
(Wiley, 2022-05-30) Çelebi Sözener, Zeynep; Cevhertaş, Laçin; Satitsuksanoa, Pattraporn; van de Veen, Willem; Jansen, Kirstin; Seçil, Derya; Sin, Betül Ayşe; Akdiş, Cezmi A.; Akdiş, Mübeccel; Mungan, Dilşad; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Fen Bilimleri Enstitüsü/Tıbbi İmmünoloji Anabilim Dalı.; FYD-1431-2022
Key role of regulatory cytokines TGF-beta and IL-10 as well as allergen-specific IgA and IgG4 in tolerance to mucosal antigens/allergens
(Mosby- Elsevier, 2002-01) Jutel, Marek; Malolepszy, Josef; Aebischer, Casaultra C.; Wrzyszcz, Maria; Blaser, Kurt; Akdiş, Mübeccel; Budak, Ferah; Akdiş, Cezmi; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; AAV-4844-2020; F-4657-2014
Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26
(Wiley, 2006) Kotenko, Sergei V.; Yılmaz, Mustafa; Mani, Orlando; Zumkehr, Judith; Blaser, Kurt; Akdiş, Cezmi A.; Akdiş, Mübeccel; Oral, Haluk B; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı/İmmünoloji Bölümü.; 0000-0003-0463-6818; K-7285-2012; 7004498001
The family of IL-10-related cytokines includes several human members, IL-19, IL-20, IL-22, IL-24 and IL-26, and a series of herpesviral and poxviral paralogs. Some of these cytokines share common receptor subunits. In this study, we investigated the effects of these cytokines on naive T cell differentiation, antigen-specific T cell suppression, survival and expression of surface markers in comparison to IL-10 and cytomegalovirus (CMV)-IL-10. Human CD45RA(+) T cells were stimulated in the presence of IL-10-family cytokines in sequential 12-day cycles. After three to four cycles of stimulation, IL-10 and CMV-IL-10 led to increased IFN-gamma and IL-10 but decreased IL-4 and IL-13. Interestingly, long-term exposure of T cells to IL-19, IL-20 and IL-22 down-regulated IFN-gamma but up-regulated IL-4 and IL-13 in T cells and supported the polarization of naive T cells toTh2-like cells. in contrast, neutralization of endogenous IL-22 activity by IL-22-binding protein decreased IL-4, IL-13 and IFN-gamma synthesis. The antigen-specific suppressor activity of IL-10 and CMV-IL-10 was not observed for any of the other IL-10-family cytokines. These data demonstrate that IL-19, IL-20 and IL-22 may participate in T cell-mediated diseases by distinct regulation of T cell cytokine profiles.
Regulatory cytokines TGF-beta and IL-10 as well as allergen-specific IgA and IgG4 play key role in tolerance to mucosal allergens in aormal immunity and specific immunotherapy
(Wiley, 2002-07) Jutel, Marek; Malolepszy, Jozef; Aebischer, Casaulta C.; Wrzyszcz, Maria; Blaser, Kurt; Budak, Ferah; Akdiş, Mübeccel; Akdis, Cezmi A.; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; 0000-0001-8020-019X; AAV-4844-2020; F-4657-2014
Tolerance mechanisms in allergen immunotherapy
(Lippincott Williams & Wilkins, 2020-12) Sözener, Zeynep Çelebi; Mungan, Dilşad; Öğülür, İsmail; Akdiş, Mübeccel; Akdiş, Cezmi; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; FYD-1431-2022; 57216918051
Purpose of review Allergen immunotherapy is the only treatment modality which alters the natural course of allergic diseases by restoring immune tolerance against allergens. Deeper understanding of tolerance mechanisms will lead to the development of new vaccines, which target immune responses and promote tolerance. Recent findings Successful allergen immunotherapy (AIT) induces allergen-specific peripheral tolerance, characterized mainly by the generation of allergen-specific Treg cells and reduction of Th2 cells. At the early phase, AIT leads to a decrease in the activity and degranulation of mast cells and basophils and a decrease in inflammatory responses of eosinophils in inflamed tissues. Treg cells show their effects by secreting inhibitory cytokines including interleukin (IL)-10, transforming growth factor-beta, interfering with cellular metabolisms, suppressing antigen presenting cells and innate lymphoid cells (ILCs) and by cytolysis. AIT induces the development of regulatory B cells producing IL-10 and B cells expressing allergen-specific IgG4. Recent investigations have demonstrated that AIT is also associated with the formation of ILC2reg and DCreg cells which contribute to tolerance induction. Research done so far, has shown that multiple molecular and cellular factors are dysregulated in allergic diseases and modified by AIT. Studies should now focus on finding the best target and ideal biomarkers to identify ideal candidates for AIT.