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Recent Submissions
Investigation of improved uricase release and kinetic parameters through dual affected responsive nanopolymers
(Elsevier Sci Ltd, 2023-06-03) Noma, Samir Abbas Ali; NOMA, Samir Abbas Ali; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.; ABH-1773-2021
Uricase suppresses the harmful effects of uric acid accumulation by the degradation of uric acid to allantoin. Maintaining enzyme stability is a major challenge. The stability issue can be avoided when using enzymes loaded into polymeric structures. For this purpose, uricase loaded into responsive nanopolymers (UO-RNPs) was synthesized. The characterizations such as SEM, FTIR, and zeta potential of UO-RNPs were performed. Maximum uricase loading to RNPs was investigated and the release performance of UO-RNPs also under variable conditions such as pH and temperature. On the other hand, loading yield (LY) and loading efficiency (LE) was founded 73.22 & PLUSMN; 3.62% and 71.24 & PLUSMN; 4.61%, while storage stability and reusability of the UO-RNPs were found to be about 68% and 51% of the original activity after 4 weeks and 10 cycles, respectively. From Lineweaver-Burk plot the Km was founded 0.192 and 0.327 mM for loaded and free uricase. While V max was founded 0.131 and 0.0714 & mu;M/min for free uricase and UO-RNPs, respectively. UO-RNPs showed promising matrices for high catalytic efficiency and enhanced stability. Up until now, as far as we know, the present study of the loaded uricase into responsive nanopolymers is the first attempt of uricase enzyme in such an investigation.
Dummy molecularly imprinted polymer-based solid-phase extraction method for the determination of some phthalate monoesters in urine by gas chromatography-mass spectrometry analysis
(Elsevier, 2023-11-24) Küçük, Melike; Osman, Bilgen; Özer, Elif Tumay; KÜÇÜK, MELİKE; OSMAN, BİLGEN; TÜMAY ÖZER, ELİF; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.; 0000-0001-8406-149X; V-1616-2019; JCP-4547-2023; JME-2199-2023
A dummy molecularly imprinted polymer-based solid-phase extraction (SPE) sorbent was used for the selective extraction of some phthalate monoesters, monoethyl phthalate (MEP), monobutyl phthalate (MnBP) and mono-(2-ethylhexyl) phthalate (MEHP) in urine prior to gas-chromatography-mass spectrometry (GC-MS) analysis. Diethyl phthalate (DEP), a phthalate ester, was successfully used as a dummy template to prepare selective sorbent for MEP, MnBP, and MEHP extraction. DEP-imprinted poly(ethylene glycol dimethacrylate N-meth-acryloyl-L-tryptophan methyl ester) (DPEMT) microbeads were synthesized by suspension polymerization and characterized by Fourier Transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Brunauer Emmet Teller (BET) analysis. The critical parameters (i.e., pH, sorbent amount, ionic strength, sample volume, elution solvent) affecting the extraction performance of the DPEMT-SPE sorbent were optimized. Under optimum conditions, good linearities were obtained in the concentration range of 4 to 60 ng/mL with deter-mination coefficients (R2) of greater than 0.9959. The developed SPE method provided low limits of detection (LOD) of 0.05-1.20 ng/mL and limits of quantification (LOQ) of 0.18-4.01 ng/mL with relative standard de-viations (RSDs) of less than 8.95 % for intra-and inter-day analyses. The proposed SPE method was used to analyze phthalate monoesters in spiked urine samples, and recoveries of 97.45-109.26 % were obtained. DPEMT-SPE sorbent was reused for 15 times without any losses of performance. Consequently, a highly selective and sensitive SPE method based on a dummy molecularly imprinted polymer combined with GC-MS was suc-cessfully developed to monitor human phthalate exposure via urine samples.
Coexistence of gastric multiple neuroendocrine tumors with unusual morphological features and gastric signet-ring cell carcinoma
(Aves, 2018-06-01) Sarkut, Pınar; Ugras, Nesrin; UĞRAŞ, NESRİN; Yerci, Ömer; YERCİ, ÖMER; Öztürk, Ersin; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-2716-2021
The coexistence of signet-ring cell carcinoma and neuroendocrine tumors is very rare. We report a 57-year-old man who presented with a history of weight loss and nausea. Gastric mucosal biopsies obtained during gastrointestinal endoscopy revealed a gastric signet-ring cell carcinoma. The patient underwent a total gastrectomy with a standard D2 lymph node dissection. Ten individual tumors were detected in the resected specimen. Based on the histopathological and immunohistochemical findings, the final diagnosis was co-existing signet-ring cell carcinoma and neuroendocrine tumor. Spindle-shaped cells and extracytoplasmic mucin were noted in some tumor cells forming the neuroendocrine component. This case is a rare synchronous tumor because of its unusual neuroendocrine component.
Effect of stationary magnetic field on seed germination and crop yield in spinach ( spinacia oleracea l.)
(Publ House Bulgarian Acad Sci, 2019-01-01) Alpsoy, Hüseyin Can; ALPSOY, HÜSEYİN CAN; Ünal, Halil; ÜNAL, HALİL; Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Biyosistem Mühendisliği Bölümü.; Bursa Uludağ Üniversitesi/Yenişehir Meslek Yüksekokulu.; AAH-4410-2021
This study was carried out with the aim of investigating the effects of different doses and periods of stationary magnetic field (0, 150 mT - 1 h, 150 mT - 24 h, 300 mT - 1 h, 300 mT - 24 h) on the parameters of germination percentage, germination index, mean germination time, mean time to germination, coefficient of velocity of germination, germination energy, mean daily germination, speed of germination and time to 10, 30, 50, 70 and 90% germination in the seeds of spinach cv. Matador, as well as on further plant development and yield. According to the research results, different magnetic field treatments had statistically significant effects on the germination parameters mentioned above. Magnetic field treatment of 150 mT-1 h gave the best results in general, however, the values obtained with this treatment were in the same statistical group with control values, regarding the parameters of germination percentage, germination index and mean daily germination. Plant yield was also positively affected by the same magnetic treatment in spring growing, whereas it was found ineffective in fall growing. Other magnetic field treatments (150 mT 24 h, 300 mT - 1 h and 300 mT - 24 h), generally had adverse effects on the germination parameters. As a result, it was concluded that subjecting the seeds to 150 mT stationary magnetic field for 1 h may be recommended for improving germination characteristics and the resulting yield, especially for spring-sown spinach seeds.
Use of coffee silverskin to improve the functional properties of cookies
(Springer India, 2019-06-01) GÖÇMEN, DUYGU; ŞAHAN, YASEMİN; YILDIZ, ELİF; Yıldız, Elif; Coşkun, Meral; Aroufai, Idriss Amit; Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Gıda Mühendisliği Bölümü.; 0000-0003-1356-9012; AAG-6424-2021; ABE-6748-2020; KDP-3344-2024
The purpose of this study was to determine the suitability of coffee silverskin (CSS) supplementation to enhance phenolic content and antioxidant capacity of cookies. Cookie samples were prepared with partial replacement of wheat flour by CSS (2.5, 5.0, and 7.5%). Spread ratios were found lower in all cookies with CSS than in control. Cookies became darker with increasing levels of CSS. This is due to the fact that CSS has a dark color like cocoa. CSS supplementation had improved functional quality of cookies by increasing phenolic contents, antioxidant capacities, and in vitro bioaccessibilities of them. According to the sensory evaluation, all samples with CSS received 6 and above scores (6: like slightly, 7: like moderately) for all attributes from the panelists. The results demonstrated that CSS supplementation have a good potential for developing functional and acceptable cookies and similar bakery products.
