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Recent Submissions
Effects of citicoline administration on synaptic proteins in rapid eye movement sleep-deprived rats
(Mashhad Univ Med Sciences, 2022-05-01) Çakır, Ayşen; Öcalan, Büşra; Koç, Cansu; Suyen, Güldal Güleç; Cansev, Mehmet; Kahveci, Nevzat; ÇAKIR, AYŞEN; Öcalan, Büşra; KOÇ, CANSU; CANSEV, MEHMET; KAHVECİ, NEVZAT; 0000-0002-6097-5585; 0000-0003-2918-5064; 0000-0003-0841-8201; C-5730-2015; A-6819-2018
Objective(s): Sleep has a pivotal role in learning-memory and sleep deprivation (SD) negatively affects synaptic functioning. Cytidine-5-diphosphocholine (Citicoline) has been known to improve learning and memory functions. Our objective was to explore the effects of Citicoline on hippocampal and cortical synaptic proteins in rapid eye movement (REM) sleep-deprived rats.Materials and Methods: Rats (n=36) were randomly divided into 6 groups. Environmental control or sleep deprivation was done by placing the rat on a 13 cm diameter platform (Large Platform [LP] group) or on a 6.5 cm diameter platform (REMSD group), respectively, for 96 hours. Rats randomized for controls (Home Cage [HC] group) were followed up in home cages. Rats in each of the REMSD, LP or HC group were randomized to receive either saline (0,9%NaCl) or Citicoline (600 mu mol/kg) intraperitoneally twice a day for four days. After the experiments, rats were sacrificed; their cerebral cortices and hippocampi were dissected for analyzing the levels of pre-synaptic proteins synaptophysin and synapsin I, and the post synaptic density protein-95 (PSD-95) by Western-blotting.Results: Hippocampal levels of PSD-95, but not the pre-synaptic proteins, were reduced by REM sleep deprivation. Citicoline treatment ameliorated the reduction in PSD-95 levels in REM sleep deprived rats. On the other hand, REM sleep deprivation was not found to be significantly effective on pre-or post-synaptic proteins in cerebral cortex.Conclusion: REM sleep deprivation reduces hippocampal PSD-95 levels which are enhanced by Citicoline treatment. These data propose that Citicoline may ameliorate the adverse effects of SD on hippocampal synaptic functioning.
Disease and quality of life aspects of cat allergy in non-pet owners with allergic rhinitis
(Karger, 2023-03-29) Aslıer, Nesibe Gül Yüksel; Saatçi, Özlem; Aslıer, Mustafa; ASLIER, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Hastalıkları Anabilim Dalı.; IYJ-7551-2023
Introduction: The severity of cat allergy-related symptoms varies widely. The rising prevalence of cat owning makes it a significant human health problem. The aim of this study was to evaluate disease severity and quality of life (QoL) aspects of cat sensitization and allergy in non-pet owners with allergic rhinitis (AR). Methods: In this study, 231 out of 596 patients with AR were enrolled. The disease severity and QoL measures of the non-pet owner patients were evaluated according to their demographics and allergen sensitizations. The data were re-gathered after cat exposure for cat-sensitized patients (n = 53). Results: The median age of the patients (174 females, 57 males) was 33 (18-70). The overall frequency of cat sensitization was 12.6% (75/596). The frequency of cat allergy in this cohort was 13.9% (32/231). Family history of atopy and multi-allergen sensitization were more common in the cat-sensitized patients. Disease severity and QoL scores were higher in the cat allergy group after cat exposure. Cat allergy was the major independent risk factor for the severity of AR and QoL measures. Conclusion: Due to the fact that indirect exposure to cat dander allergens can occur anywhere, even where cats are not present, cat-sensitized people should be aware of cat allergy. Cat allergy appears to be an independent risk factor for disease severity and QoL effects for non-pet owner patients with AR.
Riemannian manifolds with a semi-symmetric non-metric connection satisfying some semisymmetry conditions
(Int Center Scientific Research & Studies, 2011-01-01) Doğru, Yusuf; Özgür, Cihan; Murathan, Cengizhan; MURATHAN, CENGİZHAN; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Matematik Anabilim Dalı.; ABE-8167-2020
We study on a Riemannian manifold (M, g) with a semi-symmetric non-metric connection. We obtain some characterizations for (M,g) satisfying some semisymmety conditions.
Multi wave, kink, breather, interaction solutions and modulation instability to a conformable third order nonlinear schrodinger equation
(Springer, 2023-04-01) Ay, Nursena Günhan; GÜNHAN, NURSENA; Yaşar, Emrullah; YAŞAR, EMRULLAH; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Matematik Anabilim Dalı.; 0000-0002-1919-2431; 0000-0003-4732-5753; HNT-0160-2023; HOC-4413-2023
The purpose of this work is the examine the three-waves, double exponential, homoclinic breather, and periodic cross kink-soliton solutions for a third-order fractional nonlinear Schrodinger equation (3-FNLS). This model which is vital in fiber optics, explains the propagation of light in optical fibers when ultra-short pulses are produced. We define the model in terms of the conformable time fractional derivative operator so that the model could give a better description of the physical aspect. By picking the activation function in Hirota bilinear form, as the hyperbolic, trigonometric and exponential function along with suitable dispose of parameters, we acquire the three-waves, double exponential, homoclinic breather, and periodic cross kink-soliton auspiciously. Additionally, we have elucidated some three-dimensional and contour portraits to foresee the wave dynamics. These acquired new solutions that do not exist in the literature include some free constants and thereby can be significant to describe variety in qualitative aspects of wave phenomena. At last, we also check the stability of the governing model. By executing the modulation instability analysis, we scrutinize the stability analysis of the yielded exact solutions and the movement role of the waves.
Determination of sliced pineapple drying characteristics in a closed loop heat pump assisted drying system
(Diponegoro Univ, 2018-02-01) Tunçkal, Cüneyt; Coskun, Salih; Doymaz, İbrahim; Ergün, Enes; Bursa Uludağ Üniversitesi/Mühendislik Fakültesi/Makina Mühendisliği Bölümü.; 0000-0002-9395-3534; EUU-6698-2022
Pineapple (Ananascomosus) slices were dried with the aid of a heat pump assisted dryer (HPD). During this process, air velocity was kept constant at 1m/s, while air temperatures were changed as 37 degrees C, 40 degrees C and 43 degrees C. The drying air was also circulated by using an axial fan in a closed cycle and fresh air was not allowed into the system. The drying rate and drying time were significantly influenced by drying temperature. It was observed that drying temperatures had significant effects on the drying rate and drying time. During the conduct of the study, pineapple slices were dried at 37, 40 and 43 degrees C for 465, 360 and 290 min, respectively. The specific moisture extraction ratio (SMER) values were observed to change as drying temperatures were changed. The drying rate curves indicated that the whole drying process occurred in the falling rate period. Seven well-known thin-layer models (Lewis, Henderson & Pabis, Logarithmic, Page, Midilli & Kucuk, Weibull and Aghbashlo et al.) were employed to make a prediction about drying kinetics through nonlinear regression analysis. The Midilli & Kucuk and Aghbashlo et al. models were consistent with the experimental data. Fick's second law of diffusion was used to determine the moisture diffusivity coefficient ranging from 3.78x10(-9) to 6.57x10(-9) m(2)/s the each of the above mentioned temperatures. The dependence of effective diffusivity coefficient on temperature was defined by means a fan Arrhenius type equation. The activation energy of moisture diffusion was found to be 75.24kJ/mol.
