Mesane kanserlerinde tümör ile ilişkili doku eozinofilisinin önemi nedir?
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Date
2010-01-12
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Uludağ Üniversitesi
Abstract
Doku eozinofil varlığı tümörlerde araştırılmalı mıdır? Tümör ile ilişkili doku eozinofil miktarı patoloji raporlarında belirtilmeli midir, yoksa bununla uğraşmak sadece zaman ve emek kaybı mıdır? Literatüre bakıldığında birçok tümör tipinde doku eozinofilisinin sağ kalıma iyi etkisi mevcuttur, ancak farklı tümör tipleri bunu inkar etmekte, eozinofillerin bir takım mediatörler yardımıyla tümör büyümesini uyardığını göstermektedir. Bazı tümörlerde ise sağ kalım ile ilişkisi gösterilememiştir. Mesane tümörlerinde doku eozinofilisinin tümöre etkisini gösteren çok az sayıda araştırma mevcuttur. Çalışmamızdaki amaç ürotelyal karsinoma tanısı almış vakalarda, doku eozinofilisinin prognostik faktörler ve sağ kalım ile ilişkisini incelemek, bunun sonucunda literature katkıda bulunmaktır. Retrospektif çalışmamız 1996–2002 yılları arasında tanı almış 90 ürotelyal karsinoma olgusunu kapsamaktadır. Hastalara ait klinik bilgiler toplanıp, patoloji kesitlere tekrar bakıldı. Her hastaya ait kesitler histolojik grade, vasküler veya perinöral invazyon, lenf nodu metastazı ve en büyük büyütme alanındaki (HPFx400) eozinofil sayısına göre değerlendirildi. Eozinofil sayısı düşük, orta ve yüksek olarak gruplandırıldı. Yapılan istatistiki çalışmalar sonucunda doku eozinofil sayısının, tümör boyutu, histolojik grade, lenfovasküler invazyon, perinöral invazyon, lenf nodu metastazı ve sağ kalım ile ilişkisi bulunamamıştır. Mesane tümörlerinde doku eozinofilisinin sağ kalım ile ilişkisini kanıtlamak için daha fazla sayıda yayına ihtiyaç vardır. Daha büyük serili çalışmalarda doku eozinofilisinin araştırılması tümör tedavisine, eozinofilinin çeşitli ajanlarla stimülasyonu veya baskılanması gibi ek tedavi seçeneklerinin eklenmesi açısından yararlı olabilir
Should the presence of tissue eosinophilia be studied in tumors? Should the amount of tissue eosinophilia associated with tumor be specified in the pathology reports, or is dealing with this is just a waste of time and effort? When we check the literature, in many tumor types, tissue eosinophilia has a positive effect on the survival; however different tumor types deny this fact and show that eosinophils stimulate tumor growth via some mediators. In some tumors, its relationship with survival could not be demonstrated. A few studies, showing the effect of eosinophils on tumor in bladder carcinomas are present. The purpose of our study is to investigate the relationship of tissue eosinophilia with prognostic factors and survival in cases diagnosed with urothelial carcinoma, and eventually to contribute to the literature. Our retrospective study consisted of 90 urothelial carcinoma cases, diagnosed between 1996 and 2002. Clinical information related to the patients was collected and pathological cross-sections were re-examined. Cross-sections belonging to each patient were assessed in respect to histological grade, vascular or perineural invasion, lymph node metastasis and the number of eosinophils in the biggest area of magnification. The numbers of eosinophils were grouped as low, medium and high. As a result of he conducted statistical studies, a relationship between the number of tissue eosinophils and size of the tumor, histological grade, lymphovascular invasion, perineural invasion, lymph node metastasis and survival could not be found. More studies are necessary to prove the relationship of tissue eosinophilia in with survival in bladder carcinomas. Investigation of tissue eosinophilia in studies having more number of cases may be important in regard to tumor treatment, stimulation or suppression of eosinophilia with various agents and the inclusion of additional treatment options.
Should the presence of tissue eosinophilia be studied in tumors? Should the amount of tissue eosinophilia associated with tumor be specified in the pathology reports, or is dealing with this is just a waste of time and effort? When we check the literature, in many tumor types, tissue eosinophilia has a positive effect on the survival; however different tumor types deny this fact and show that eosinophils stimulate tumor growth via some mediators. In some tumors, its relationship with survival could not be demonstrated. A few studies, showing the effect of eosinophils on tumor in bladder carcinomas are present. The purpose of our study is to investigate the relationship of tissue eosinophilia with prognostic factors and survival in cases diagnosed with urothelial carcinoma, and eventually to contribute to the literature. Our retrospective study consisted of 90 urothelial carcinoma cases, diagnosed between 1996 and 2002. Clinical information related to the patients was collected and pathological cross-sections were re-examined. Cross-sections belonging to each patient were assessed in respect to histological grade, vascular or perineural invasion, lymph node metastasis and the number of eosinophils in the biggest area of magnification. The numbers of eosinophils were grouped as low, medium and high. As a result of he conducted statistical studies, a relationship between the number of tissue eosinophils and size of the tumor, histological grade, lymphovascular invasion, perineural invasion, lymph node metastasis and survival could not be found. More studies are necessary to prove the relationship of tissue eosinophilia in with survival in bladder carcinomas. Investigation of tissue eosinophilia in studies having more number of cases may be important in regard to tumor treatment, stimulation or suppression of eosinophilia with various agents and the inclusion of additional treatment options.
Description
Keywords
Mesane karsinomu, Bladder carcinoma, Eozinofili, Prognozis, Eosinophilia, Prognosis
Citation
Aytaç, B. ve Vuruşkan, H. (2010). "Mesane kanserlerinde tümör ile ilişkili doku eozinofilisinin önemi nedir?" Uludağ Üniversitesi Tıp Fakültesi Dergisi, 36(3),85-88.