Assessment of bone mineral density and risk factors in children completing treatment for acute lymphoblastic leukemia

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dc.contributor.buuauthorGüneş, Adalet Meral
dc.contributor.buuauthorCan, Erkan
dc.contributor.buuauthorSağlam, Halil
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorBaytan, Birol
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0710-5422tr_TR
dc.contributor.researcheridC-7392-2019tr_TR
dc.contributor.researcheridABB-7412-2020tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid24072843300tr_TR
dc.contributor.scopusid36058591600tr_TR
dc.contributor.scopusid35612700100tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid6506622162tr_TR
dc.date.accessioned2021-12-09T08:13:27Z
dc.date.available2021-12-09T08:13:27Z
dc.date.issued2010-04
dc.description.abstractBackground: Reduced bone mineral density and increased fracture risk have been reported in children with cancer. In this study, we aimed to determine the growth and bone mineral density (BMD) of the children off chemotherapy for acute lymphoblastic leukemia, and the probable risk factors. Procedure: The age, anthropometric measurements, lumbar spine BMDs were recorded in 70 children. The risk factors on BMD; daily calcium intake, the time interval from the completion of the chemotherapy, cranial radiotherapy, cumulative steroid dose, decrease in physical activity were investigated. Serum calcium, phosphate, alkaline phosphates, magnesium, insulin-like growth factor-1 (IGF-1) and 25 (OH) vitamin D levels were determined. Results: The mean height percentile at the time of diagnosis was decreased from the value of 53 to a value of 47 at the beginning of the study (P = 0.071). Of them; 44% had osteoporosis, 41% had osteopenia, and the rest had normal BMD. BMD z-scores were decreased during the first 2 years from the completion of the treatment. There was a positive correlation between BMD z-scores and daily calcium intake (CC = 0.366, P = 0.0015). A negative correlation was determined between the time spent on TV and computers and BMD z-scores (CC = -0.464, P = 0.0019). Serum IGF-1 and 25 (OH) vitamin D levels of patients were significantly lower than controls (P = 0.033). Conclusions: Our data revealed that 85% of the survivors had bone mineralization defect. BMDs and z scores were decreased during the first 2 years from the completion of the treatment and then gradually began to increase. The most important risk factor for decreased BMD was low daily calcium intake. Therefore, patients and their families should be encouraged to take sufficient amount of calcium. Prophylactic vitamin D may also be supplemented.en_US
dc.identifier.citationGüneş, A. M. vd. (2010). "Assessment of bone mineral density and risk factors in children completing treatment for acute lymphoblastic leukemia". Journal of Pediatric Hematology Oncology, 32(3), 102-107.en_US
dc.identifier.endpage107tr_TR
dc.identifier.issn1077-4114
dc.identifier.issn1536-3678
dc.identifier.issue3tr_TR
dc.identifier.pubmed20216235tr_TR
dc.identifier.scopus2-s2.0-77951027425tr_TR
dc.identifier.startpage102tr_TR
dc.identifier.urihttps://doi.org/10.1097/MPH.0b013e3181d32199
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20216235/
dc.identifier.urihttp://hdl.handle.net/11452/23120
dc.identifier.volume32tr_TR
dc.identifier.wos000276667800019tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.bapBAPtr_TR
dc.relation.journalJournal of Pediatric Hematology/Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildhooden_US
dc.subjectAcute leukemiaen_US
dc.subjectBone mineral densityen_US
dc.subjectGrowth-factor-Ien_US
dc.subjectLong-term survivorsen_US
dc.subjectBinding-proteinsen_US
dc.subjectChemotherapyen_US
dc.subjectTherapyen_US
dc.subjectHormoneen_US
dc.subjectDietaryen_US
dc.subjectCalciumen_US
dc.subjectOncologyen_US
dc.subjectHematologyen_US
dc.subjectPediatricsen_US
dc.subject.emtree25 hydroxyvitamin Den_US
dc.subject.emtreeCalciumen_US
dc.subject.emtreeCorticosteroiden_US
dc.subject.emtreeMagnesiumen_US
dc.subject.emtreePhosphateen_US
dc.subject.emtreeSomatomedin Cen_US
dc.subject.emtreeAcute lymphoblastic leukemiaen_US
dc.subject.emtreeAnthropometric parametersen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBone densityen_US
dc.subject.emtreeCalcium blood levelen_US
dc.subject.emtreeCalcium intakeen_US
dc.subject.emtreeCancer chemotherapyen_US
dc.subject.emtreeCancer radiotherapyen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeChild growthen_US
dc.subject.emtreeClinical assessmenten_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFractureen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLeukemiaen_US
dc.subject.emtreeLumbar spineen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeOsteopeniaen_US
dc.subject.emtreeOsteoporosisen_US
dc.subject.emtreePhysical activityen_US
dc.subject.emtreePreschool childen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePubertyen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeVitamin blood levelen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshBone densityen_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshCohort studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshOsteoporosisen_US
dc.subject.meshPrecursor cell lymphoblastic leukemia-lymphomaen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshSurvival rateen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.meshTumor markers, biologicalen_US
dc.subject.scopusAcute Lymphoblastic Leukemia; Bone Density; Photon Absorptiometryen_US
dc.subject.wosOncologyen_US
dc.subject.wosHematologyen_US
dc.subject.wosPediatricsen_US
dc.titleAssessment of bone mineral density and risk factors in children completing treatment for acute lymphoblastic leukemiaen_US
dc.typeArticle
dc.wos.quartileQ4en_US
dc.wos.quartileQ3 (Pediatrics)en_US

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