Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels

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dc.contributor.buuauthorYeşilbursa, Dilek
dc.contributor.buuauthorSerdar, Zehra Asiran
dc.contributor.buuauthorSerdar, Akın
dc.contributor.buuauthorSaraç, Mesud
dc.contributor.buuauthorCoşkun, Şenay
dc.contributor.buuauthorJale, C
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.date.accessioned2021-07-05T08:58:18Z
dc.date.available2021-07-05T08:58:18Z
dc.date.issued2005-01
dc.description.abstractObjective: Obesity is a well-known risk factor of atherosclerosis. Recent studies showed that obesity is associated with enhanced lipid peroxidation. The aim of this study is to investigate the effect of weight reduction with orlistat treatment on lipid peroxidation levels. We assessed lipid peroxidation by measuring the concentration of plasma malondialdehyde (MDA). Design: A randomized, controlled, open-label 6-month study. Subjects: In total, 36 obese (body mass index (BMI) 430 kg/m(2)) and 11 healthy age-matched control subjects were enrolled in the study. Measurements: Fasting glucose, triglyceride, total cholesterol, HDL cholesterol and LDL cholesterol and MDA levels were measured in both groups. Obese subjects received orlistat, 120 mg three times daily together with hypocaloric diet. After 6 months of treatment laboratory tests were repeated. Results: MDA levels were significantly higher in obese patients than the control group (P<0.0001). After 6 months of treatment in obese subjects, the mean weight of the patients decreased by 6.8 kg, the BMI by 3.2 kg/m(2). Plasma MDA levels were significantly reduced by weight loss from 2 +/- 0.77 to 0.89 +/- 0.41 nmol/ml (P<0.001). BMI correlated with MDA levels at baseline (r=0.6, P<0.0001). Changes in BMI was positively associated with plasma MDA level reduction (r=0.36, P<0.05). Conclusion: These results indicate that obesity is associated with increases in endogenous lipid peroxides. Our data show that the indicator of lipid peroxidation-MDA-falls markedly in association with weight loss with orlistat. The demonstration of decreased free radical generation has important implications for oxidative mechanism underlying obesity-associated disorders.en_US
dc.identifier.citationYeşilbursa, D. vd. (2005). "Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels". International Journal of Obesity, 29(1), 142-145en_US
dc.identifier.endpage145tr_TR
dc.identifier.issn0307-0565
dc.identifier.issue1tr_TR
dc.identifier.pubmed15467775tr_TR
dc.identifier.scopus2-s2.0-11244318176tr_TR
dc.identifier.startpage142tr_TR
dc.identifier.urihttps://doi.org/10.1038/sj.ijo.0802794
dc.identifier.urihttps://www.nature.com/articles/0802794en_US
dc.identifier.urihttp://hdl.handle.net/11452/21053
dc.identifier.volume29tr_TR
dc.identifier.wos000225710800020tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalInternational Journal of Obesityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLipid peroxidationen_US
dc.subjectWeight lossen_US
dc.subjectOrlistaten_US
dc.subjectIndependent risk factoren_US
dc.subjectOxidationen_US
dc.subjectLow-density-lipoproteinen_US
dc.subjectCoronary-heart-diseaseen_US
dc.subjectNecrosis-factor-alphaen_US
dc.subjectPlasma malondialdehydeen_US
dc.subjectBody-weighten_US
dc.subjectWomenen_US
dc.subjectReductionen_US
dc.subjectStressen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectNutrition & dieteticsen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.subject.wosNutrition & dieteticsen_US
dc.titleLipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levelsen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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