Yumuşak doku tümörlerinde olgu karakteristikleri
Loading...
Files
Date
1992
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Tüm kanser olgularının % 0.7 ile % 1 'ini oluşturan yumuşak doku tümörleri histopatolojik tiplerinin çeşitliliği, yüksek lokal rekürrens ve uzak metastaz olasılığı ile karakterize bir tümör grubudur. Çalışmada 1986 ve 1988 yılları arasında Onkoloji ve Nükleer Tip Merkezine başvuran 163 olgu incelenmiştir. Olguların % 59.5'i erkek, % 40.5'i kadın idi. Yaş gruplarına göre dağılımına bakıldığında en fazla olgunun % 38. 7'lik bir oran ile 40-60 lar arasında bulunduğu görüldü. Histopatolojik ayrımda ilk sırada liposarkomalar (% 15.3) yer aldı. Liposarkomaları malign fibröz histiositomalar (MFH, % 12.3), fibrosarkomalar (% 11.7) ve rabdomyosarkomalar (% 9.8) izliyordu. Yumuşak doku tümörlerinin en sıklıkla gövdeyi tuttuğu saptandı (% 48.4). Tutulan bölgeler arasında gövdeyi alt extremite izliyordu (% 30.1). Cerrahi girişim olarak olguların % 54. 6'sına total yada subtotal tümör rezeksiyonu, % 38'ine yalnızca biopsi uygulanmıştır. Radikal cerrahi girişim yapılmış olgu oranı yalnızca% 7.4 idi. % 41.1 olguda tam ve izlem sırasında CT kullanılmıştır. Post-operatif onkolojik tedavi olarak % 33.7 olguda yalnızca radyoterapi, % 13.5 olguda yalnızca kemoterapi ve% 19.1 olguda kemoradyoterapi kombinasyonu uygulanmıştır. % 33. 7 olguda ise çeşitli nedenler ile cerrahi sonrası herhangi bir tedavi uygulanmamıştır. İzlem yapılabilen olgularda fokal rekürrens oranı % 16.6, uzak metastaz oranı % 23.3 olarak bulunmuştur. En sık karşılaşılan uzak metastaz bölgesi akciğer olmuştur (% 77.5). Akciğer metastazlarının yanı sıra cilt, karaciğer, kemik, beyin ve orbita metastazları saptanmıştır. Ortalama izlem lipostar noktalar için 12.3 ±2.1 ay, malignant fibröz histiositomalar için 11.3 ± 1.3 ay, fibrosarkomalar için 11.9 ± 1. 7 ay ve rabdomyosarkomalar için 9.5 ± 1.1 ay olarak bulunurken tüm olgular için 10.6 ± 1.0 ay olarak saptanmıştır.
Soft tissue sarcomas are rare tumors characterized with various histopothological types, high local recurrence and distant metastasis rates. In this study, 163 soft tissue sarcoma cases who were admitted to the Center of Oncology & Nuclear Medicine, Istanbul, between 1986 and 1988, were analyzed retrospectively. 59.5 % of the cases were male and 40.5 % were female. Most of the cases were in 40-60 years age group (38.7 %) 15.3 % of the cases were liposarcomas, 12.3 % malignant fibrous histiocytomas, 11. 7 % fibrosarcomas and 9.8 % rhabdomyosarcomas. In the great majority of the cases, truncal body was the initially involved area (48.4 %). Lower extremity was following the truncal body (30. 1 %). In 54.6% of the cases, total or subtotal tumor resection was performed. Biopsy alone was taken in 38 % of the cases. Radical surgical procedures were done only in 7.4 % of the cases. CT Seans were taken in 41.1 %. In 33.7 % of the cases, radiation therapy was the only treatment modality used. Chemotherapy alone was given in 13.5 % of the cases and chemoradiotherapy combination in 19.1 %. 33.7% of the patients were lost to follow-up because of various reasons. In the rest of the patients, local recurrence rate was 16.6 %and distant metastasis rate 23.3 %. The most common distant metastases were seen in the lung (77.5 %). Mean survival for all patients was 10.6 ± 1.0 (SE) montlıs. Mean survival was 12.3 ±2.1 months for liposarcoma, 11.3 ± 1.3 montlıs for malignant fibrous histiocytomas, 11.9 ±I. 7 months for fibrosarcomas and 9.5 ± 1.1 months for rhabdomyosarcomas (p = 0.31).
Soft tissue sarcomas are rare tumors characterized with various histopothological types, high local recurrence and distant metastasis rates. In this study, 163 soft tissue sarcoma cases who were admitted to the Center of Oncology & Nuclear Medicine, Istanbul, between 1986 and 1988, were analyzed retrospectively. 59.5 % of the cases were male and 40.5 % were female. Most of the cases were in 40-60 years age group (38.7 %) 15.3 % of the cases were liposarcomas, 12.3 % malignant fibrous histiocytomas, 11. 7 % fibrosarcomas and 9.8 % rhabdomyosarcomas. In the great majority of the cases, truncal body was the initially involved area (48.4 %). Lower extremity was following the truncal body (30. 1 %). In 54.6% of the cases, total or subtotal tumor resection was performed. Biopsy alone was taken in 38 % of the cases. Radical surgical procedures were done only in 7.4 % of the cases. CT Seans were taken in 41.1 %. In 33.7 % of the cases, radiation therapy was the only treatment modality used. Chemotherapy alone was given in 13.5 % of the cases and chemoradiotherapy combination in 19.1 %. 33.7% of the patients were lost to follow-up because of various reasons. In the rest of the patients, local recurrence rate was 16.6 %and distant metastasis rate 23.3 %. The most common distant metastases were seen in the lung (77.5 %). Mean survival for all patients was 10.6 ± 1.0 (SE) montlıs. Mean survival was 12.3 ±2.1 months for liposarcoma, 11.3 ± 1.3 montlıs for malignant fibrous histiocytomas, 11.9 ±I. 7 months for fibrosarcomas and 9.5 ± 1.1 months for rhabdomyosarcomas (p = 0.31).
Description
Bu çalışma, Mayıs 1989 tarihinde İstanbul[Türkiye]'da düzenlenen 8. Ulusal Kanser Kongresinde bildiri olarak sunulmuştur.
Keywords
Yumuşak doku tümörleri, Olgu karakteristikleri, Soft tissue tumors, Olguda tanı, Case characteristics, Diagnosis in the case
Citation
Engin, K. (1992). ''Yumuşak doku tümörlerinde olgu karakteristikleri''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 19(2), 193-200.