Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid

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dc.contributor.buuauthorFazlıoğlu, Murat
dc.contributor.buuauthorŞentürk, Tunay
dc.contributor.buuauthorKumbay, Ethem
dc.contributor.buuauthorKaderli, Aysel Aydın
dc.contributor.buuauthorYılmaz, Yusuf
dc.contributor.buuauthorÖzdemir, Bülent
dc.contributor.buuauthorBaran, İbrahim
dc.contributor.buuauthorAydınlar, Ali
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-4518-5283tr_TR
dc.contributor.orcid0000-0002-8974-8837tr_TR
dc.contributor.researcheridK-6651-2012tr_TR
dc.contributor.researcheridAAI-6632-2021tr_TR
dc.contributor.researcheridC-1517-2017tr_TR
dc.contributor.scopusid23988764000tr_TR
dc.contributor.scopusid8342098300tr_TR
dc.contributor.scopusid6507775316tr_TR
dc.contributor.scopusid7801322152tr_TR
dc.contributor.scopusid22936014300tr_TR
dc.contributor.scopusid7004168959tr_TR
dc.contributor.scopusid35572557400tr_TR
dc.contributor.scopusid6603131517tr_TR
dc.date.accessioned2021-12-10T08:25:58Z
dc.date.available2021-12-10T08:25:58Z
dc.date.issued2009-01
dc.description.abstractBackground: Arterial elasticity has been previously linked to atherosclerotic vascular disease states. Serum uric acid level has been recently associated with increased arterial stiffness, but to what extent serum uric acid reflects angiographic coronary artery status and vessel compliance remains to be established. In this study we aimed to evaluate the association of arterial elasticity indexes, serum uric acid and the presence and extent of angiographic coronary artery disease (CAD) in patients with chronic stable angina. Methods: One hundred and eight consecutive patients attending for elective coronary angiography were investigated. The severity of CAD was expressed using the Gensini score. Quantitative analysis of the arterial elasticity was performed by applanation tonometry. Serum uric acid was measured in all participants. Stepwise multiple linear regression analysis was used to identify the independent correlates of the Gensini score. Results: After adjustment for age, gender, common cardiac risk factors and cardiovascular drugs, small artery elasticity index (SAEI) (p < 0.001) and Serum uric acid (p < 0.001) were independently correlated with the severity of CAD. Stepwise multiple linear regression analysis was also used to identify independent correlates of the SAEI. Serum uric acid emerged as the only independent correlate of SAEI (P < 0.001). Conclusions: SAEI independently reflects the extent of CAD in patients with chronic stable angina. This relationship is chiefly mediated by serum uric acid. Our data add to the growing evidence that serum uric acid may be a marker of arterial stiffness and atherosclerotic burden.en_US
dc.identifier.citationFazlıoğlu, M. vd. (2009). "Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid". Atherosclerosis, 202(1), 200-204.en_US
dc.identifier.endpage204tr_TR
dc.identifier.issn0021-9150
dc.identifier.issue1tr_TR
dc.identifier.pubmed18511056tr_TR
dc.identifier.scopus2-s2.0-57649195078tr_TR
dc.identifier.startpage200tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.atherosclerosis.2008.04.014
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0021915008002542
dc.identifier.urihttp://hdl.handle.net/11452/23165
dc.identifier.volume202tr_TR
dc.identifier.wos000262729400028tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Irelanden_US
dc.relation.journalAtherosclerosisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArterial stiffnessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectUric aciden_US
dc.subjectHeart-diseaseen_US
dc.subjectCardiovascular-diseaseen_US
dc.subjectRisken_US
dc.subjectAssociationen_US
dc.subjectStiffnessen_US
dc.subjectMarkeren_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subject.emtreeUric aciden_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAngiocardiographyen_US
dc.subject.emtreeArterial stiffnessen_US
dc.subject.emtreeArtery toneen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCardiovascular risken_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCoronary artery diseaseen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeElasticityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePlaque forming cellen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeTonometryen_US
dc.subject.emtreeUnstable angina pectorisen_US
dc.subject.emtreeUric acid blood levelen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAngina pectorisen_US
dc.subject.meshCoronary angiographyen_US
dc.subject.meshCoronary artery diseaseen_US
dc.subject.meshElasticityen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshManometryen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshRisk factorsen_US
dc.subject.meshUric aciden_US
dc.subject.scopusHyperuricemia; Uric Acid; Gouten_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.subject.wosPeripheral vascular diseaseen_US
dc.titleSmall arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric aciden_US
dc.typeArticle
dc.wos.quartileQ1en_US

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