Nutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses

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dc.contributor.authorWurtman, Richard J.
dc.contributor.authorSakamoto, Toshimasa
dc.contributor.authorUlus, İsmael
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.date.accessioned2021-11-10T08:50:28Z
dc.date.available2021-11-10T08:50:28Z
dc.date.issued2010-12
dc.description.abstractBrain phosphatide synthesis requires three circulating compounds: docosahexaenoic acid (DHA), uridine, and choline. Oral administration of these phosphatide precursors to experimental animals increases the levels of phosphatides and synaptic proteins in the brain and per brain cell as well as the numbers of dendritic spines on hippocampal neurons. Arachidonic acid fails to reproduce these effects of DHA. If similar increases occur in human brain, administration of these compounds to patients with diseases that cause loss of brain synapses, such as Alzheimer's disease, could be beneficial.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USAtr_TR
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Mental Health (NIMH) (R01MH028783)tr_TR
dc.identifier.citationWurtman, Richard. J. vd. (2010). "Nutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses". Nutrition Reviews, 68(12), 88-101.en_US
dc.identifier.endpage101tr_TR
dc.identifier.issn0029-6643
dc.identifier.issn1753-4887
dc.identifier.issue12tr_TR
dc.identifier.pubmed21091953tr_TR
dc.identifier.scopus2-s2.0-78649436932tr_TR
dc.identifier.startpage88tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1753-4887.2010.00344.x
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21091953/
dc.identifier.urihttp://hdl.handle.net/11452/22616
dc.identifier.volume68tr_TR
dc.identifier.wos000284587300006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalNutrition Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAging brain functionen_US
dc.subjectNutritional modifiersen_US
dc.subjectPhosphatide precursorsen_US
dc.subjectUridineen_US
dc.subjectPlus docosahexaenoic aciden_US
dc.subjectCDP-choline levelsen_US
dc.subjectRat-brainen_US
dc.subjectAlzheimers-diseaseen_US
dc.subjectFatty-aciden_US
dc.subjectNeurite outgrowthen_US
dc.subjectPheochromocytoma cellsen_US
dc.subjectTranscription factorsen_US
dc.subjectGlutamate receptorsen_US
dc.subjectSynaptic plasticityen_US
dc.subjectNutrition & dieteticsen_US
dc.subjectAnimaliaen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeDocosahexaenoic aciden_US
dc.subject.emtreeOmega 3 fatty aciden_US
dc.subject.emtreeUridineen_US
dc.subject.emtreeAlzheimer diseaseen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBehavioren_US
dc.subject.emtreeBrain cellen_US
dc.subject.emtreeBrain developmenten_US
dc.subject.emtreeBrain functionen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeCognitionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeNerve cell networken_US
dc.subject.emtreeNeuriteen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeProtein synthesisen_US
dc.subject.emtreeSynapseen_US
dc.subject.emtreeSynaptic membraneen_US
dc.subject.emtreeSynaptogenesisen_US
dc.subject.emtreeVerbal memoryen_US
dc.subject.scopusCholine Phosphate Cytidylyltransferase; Phosphatidylcholines; Citicolineen_US
dc.subject.wosNutrition & dieteticsen_US
dc.titleNutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapsesen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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