Elevation of serum cerebral injury markers correlates with serum choline decline after coronary artery bypass grafting surgery

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dc.contributor.buuauthorİlçöl, Özarda Yeşim
dc.contributor.buuauthorBaşağan-Moğol, Elif
dc.contributor.buuauthorCengiz, Mete
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Merkez Laboratuvarı.tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid7003766367tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.contributor.scopusid23982134100tr_TR
dc.date.accessioned2021-12-22T06:51:48Z
dc.date.available2021-12-22T06:51:48Z
dc.date.issued2006
dc.description.abstractThe aims of this study were to determine circulating choline status and its relationship to circulating levels of S-100b protein and neuron-specific enolase, biochemical markers of cerebral injury and cognitive decline, after coronary artery bypass grafting ( CABG) surgery. Preoperatively, patients scheduled for off-pump or on- pump CABG surgery had serum concentrations of 12.0 +/- 0.2 and 11.7 +/- 0.4 mmol/L free choline and 2640 +/- 65 and 2675 +/- 115 mmol/L phospholipid-bound choline, respectively. Serum free and bound choline levels decreased by 22-37% or 34-47% and 16-36% or 31-38% at 48 h after off-pump or on- pump surgery, respectively. Serum S-100b and neuron-specific enolase increased from preoperative values of 0.083 +/- 0.009 and 6.3 +/- 0.2 mg/L to 0.405 +/- 0.022 and 11.4 +/- 0.8 mg/L, respectively, at 0 h postoperatively and remained elevated for 48 h after off-pump surgery. Serum free and bound choline concentrations were inversely correlated with the concentrations of S-100b ( r=-0.798; p<0.001 and r=-0.734; p<0.001) and neuron-specific enolase ( r=-0.840; p<0.001 and r=-0.728; p<0.001). In conclusion, CABG surgery induces a decline in serum free and phospholipid-bound choline concentrations. The decreased serum choline concentrations were inversely correlated with the elevated levels of circulating cerebral injury markers. Thus, a decline in circulating choline may be involved in postoperative cognitive decline.en_US
dc.identifier.citationİlçöl, Ö. Y. vd. (2006). ''Elevation of serum cerebral injury markers correlates with serum choline decline after coronary artery bypass grafting surgery''. Clinical Chemistry and Laboratory Medicine, 44(4), 471-478.en_US
dc.identifier.endpage478tr_TR
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue4tr_TR
dc.identifier.pubmed16599843tr_TR
dc.identifier.scopus2-s2.0-33645795517tr_TR
dc.identifier.startpage471tr_TR
dc.identifier.urihttps://doi.org/10.1515/CCLM.2006.074
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/CCLM.2006.074/html
dc.identifier.urihttp://hdl.handle.net/11452/23437
dc.identifier.volume44tr_TR
dc.identifier.wos000236956300019tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWalter de Gruyteren_US
dc.relation.journalClinical Chemistry and Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedical laboratory technologyen_US
dc.subjectS-100βen_US
dc.subjectNeuron-specific enolase (NSE)en_US
dc.subjectFree cholineen_US
dc.subjectCoronary artery surgeryen_US
dc.subjectCognitive declineen_US
dc.subjectBrain injuryen_US
dc.subjectCardiac-surgeryen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectPlasma cholineen_US
dc.subjectCognitive dysfunctionen_US
dc.subjectOn-pumpen_US
dc.subjectRat-brainen_US
dc.subjectOff-pumpen_US
dc.subjectNeuron-specific enolaseen_US
dc.subjectProton magnetic-resonanceen_US
dc.subjectHippocampal acetylcholine-releaseen_US
dc.subject.emtreeProtein S100Ben_US
dc.subject.emtreePhospholipiden_US
dc.subject.emtreeNeuron specific enolaseen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeUpregulationen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePreoperative evaluationen_US
dc.subject.emtreePostoperative perioden_US
dc.subject.emtreePostoperative complicationen_US
dc.subject.emtreeOff pump coronary surgeryen_US
dc.subject.emtreeMental deteriorationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeEnzyme blood levelen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeCoronary artery bypass graften_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeBrain injuryen_US
dc.subject.emtreeBlood analysisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAgeden_US
dc.subject.meshTime factorsen_US
dc.subject.meshS100 proteinsen_US
dc.subject.meshPhosphopyruvate hydrataseen_US
dc.subject.meshNerve growth factorsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMaleen_US
dc.subject.meshHumansen_US
dc.subject.meshFemaleen_US
dc.subject.meshCoronary drtery bypassen_US
dc.subject.meshCognition disordersen_US
dc.subject.meshCholineen_US
dc.subject.meshBrain diseasesen_US
dc.subject.meshBiological markersen_US
dc.subject.meshAgeden_US
dc.subject.meshAdulten_US
dc.subject.scopusCholine; Dimethylglycine; Betainesen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleElevation of serum cerebral injury markers correlates with serum choline decline after coronary artery bypass grafting surgeryen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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