The role of triple therapy, age, gender and smoking on the genotoxic effects of helicobacter pylori infection

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dc.contributor.authorTokyay, Nuray Denli
dc.contributor.authorKarakaya, Ali Esat
dc.contributor.authorSardaş, Semra
dc.contributor.buuauthorGülten, Tuna
dc.contributor.buuauthorDemiray, Mutlu
dc.contributor.buuauthorErcan, İlker
dc.contributor.buuauthorGülten, Macit
dc.contributor.buuauthorEvke, Erin E.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları ve Gastroenteroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.orcid0000-0003-2501-3097tr_TR
dc.contributor.researcheridM-8060-2019tr_TR
dc.contributor.scopusid6505944216tr_TR
dc.contributor.scopusid6603631569tr_TR
dc.contributor.scopusid6603629209tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.date.accessioned2021-12-10T12:59:16Z
dc.date.available2021-12-10T12:59:16Z
dc.date.issued2002
dc.description.abstractThe role of age, gender and smoking on both the genotoxic effects of Helicobacter pylori and the efficacy of eradication therapy in a group of patients with gastritis was investigated. Gastritis was confirmed by endoscopy and biopsy, and the presence of H. pylori by urease testing. Pre- and post-treatment peripheral blood lymphocyte cultures were prepared from 17 patients and 25 metaphases per patients were analysed for sister chromatid exchange (SCE), a well-established technique for the evaluation of human exposure to toxic agents. Treatment with omeprazole clarithromycin and amoxycillin triple therapy eradicated H. pylori in 94% of patients and significantly reduced the SCE frequency. Pre-treatment SCE frequency was found to be positively correlated with age. Female smokers tended to have higher post-treatment SCE frequencies than male smokers, and pre- and post-treatment SCE frequencies were higher in older males than in older females. Eradication therapy decreased the genotoxicity of H. pylori, but age in males and smoking in females may decrease treatment efficacy.en_US
dc.identifier.citationGülten, T. vd. (2002). "The role of triple therapy, age, gender and smoking on the genotoxic effects of helicobacter pylori infection". Journal of International Medical Research, 30(4), 380-385.en_US
dc.identifier.endpage385tr_TR
dc.identifier.issn0300-0605
dc.identifier.issue4tr_TR
dc.identifier.pubmed12235919tr_TR
dc.identifier.scopus2-s2.0-0036630134tr_TR
dc.identifier.startpage380tr_TR
dc.identifier.urihttps://doi.org/10.1177/147323000203000403
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/147323000203000403
dc.identifier.urihttp://hdl.handle.net/11452/23178
dc.identifier.volume30tr_TR
dc.identifier.wos000177800900003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgeen_US
dc.subjectSister chromatid exchangesen_US
dc.subjectEradication therapyen_US
dc.subjectGenderen_US
dc.subjectGenotoxicityen_US
dc.subjectHelicobacter pylori infectionen_US
dc.subjectSister chromatid exchangeen_US
dc.subjectSmokingen_US
dc.subjectFrequencyen_US
dc.subjectCanceren_US
dc.subjectDiseaseen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.emtreeOmeprazoleen_US
dc.subject.emtreeAmoxicillinen_US
dc.subject.emtreeClarithromycinen_US
dc.subject.emtreeUreaseen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeEnzyme assayen_US
dc.subject.emtreeGastritisen_US
dc.subject.emtreeEradication therapyen_US
dc.subject.emtreeExposureen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGenderen_US
dc.subject.emtreeGastroscopyen_US
dc.subject.emtreeGenotoxicityen_US
dc.subject.emtreeHelicobacter infectionen_US
dc.subject.emtreeHelicobacter pylorien_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLymphocyte cultureen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetaphaseen_US
dc.subject.emtreePeripheral lymphocyteen_US
dc.subject.emtreeSister chromatid exchangeen_US
dc.subject.emtreeSmokingen_US
dc.subject.emtreeStomach biopsyen_US
dc.subject.meshClarithromycinen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge factorsen_US
dc.subject.meshAmoxicillinen_US
dc.subject.meshFemaleen_US
dc.subject.meshDrug therapy, combinationen_US
dc.subject.meshHelicobacter infectionsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshOmeprazoleen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshSex factorsen_US
dc.subject.meshSister chromatid exchangeen_US
dc.subject.meshSmokingen_US
dc.subject.meshStomach neoplasmsen_US
dc.subject.scopusSister Chromatid Exchange; Cytogenetics; Lymphocytesen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleThe role of triple therapy, age, gender and smoking on the genotoxic effects of helicobacter pylori infectionen_US
dc.typeArticle

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