Restoration of blood pressure by centrally injected U-46619, a thromboxane A(2) analog, in hemorrhaged hypotensive rats: Investigation of different brain areas

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dc.contributor.buuauthorYalçın, Murat
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.contributor.scopusid6603687024tr_TR
dc.date.accessioned2021-09-01T10:49:22Z
dc.date.available2021-09-01T10:49:22Z
dc.date.issued2004
dc.description.abstractIn the present study, we investigated the cardiovascular effects of centrally injected U-46619, a thromboxane A(2) (TXA(2)) analog, and the central and peripheral mechanisms of these effects in hemorrhagic shock conditions. Hemorrhage was performed by withdrawing a total volume of 2.1 ml of blood/100 g body weight over a period of 10 min. Injections were made into the lateral cerebral ventricle (LCV), nucleus tractus solitarius (NTS), rostral ventrolateral medulla (RVLM) and paraventricular nucleus of hypothalamus (PVN). U-46619 (0.1, 1 and 2 mug) increased blood pressure and reversed hypotension in hemorrhagic shock. The pressor effect was dose- and time-dependent in all investigated brain areas. Heart rate changes were not significantly different in all groups. Pretreatment of rats with an injection of SQ-29548 ( 4 or 8 mug), a TXA(2) receptor antagonist, into the LCV, NTS, RVLM and PVN completely blocked the pressor effect of U-46619 (1 mug) injected into respective brain areas. Hemorrhage itself increased plasma adrenaline, noradrenaline, vasopressin levels and renin activity. U-46619 (1 mug) injected into the LCV, PVN, RVLM and NTS produced additional increases in these hormone levels and in renin activity. Intravenous pretreatments of rats with prazosin (0.5 mg/kg), an alpha(1)-adrenoceptor antagonist, [beta-mercapto-beta, beta-cyclopentamethylenepropionyl(1), O-Me-Tyr(2), Arg(8)]-vasopressin (10 mug/kg), a vasopressin V-1-receptor antagonist, or saralasin (250 mug/kg), an angiotensin II receptor antagonist, in hemorrhaged rats partially blocked the pressor response to U-46619 (1 mug) injected into the LCV, PVN, RVLM and NTS. Results show that centrally administered U-46619, a TXA(2) analog, increases blood pressure and reverses hypotension in hemorrhagic shock. Activation of central TXA(2) receptors mediates the pressor effect of the drug. Furthermore, the increases in plasma adrenaline, noradrenaline, vasopressin levels and renin activity are involved in these effects.en_US
dc.identifier.citationYalçın, M. ve Savcı, V. (2004). “Restoration of blood pressure by centrally injected U-46619, a thromboxane A(2) analog, in hemorrhaged hypotensive rats: Investigation of different brain areas”. Pharmacology, 70(4), 177-187.en_US
dc.identifier.endpage187tr_TR
dc.identifier.issn0031-7012
dc.identifier.issue4tr_TR
dc.identifier.pubmed15001818tr_TR
dc.identifier.scopus2-s2.0-1542313854tr_TR
dc.identifier.startpage177tr_TR
dc.identifier.urihttps://doi.org/10.1159/000075546
dc.identifier.urihttps://www.karger.com/Article/Abstract/75546
dc.identifier.urihttp://hdl.handle.net/11452/21602
dc.identifier.volume70tr_TR
dc.identifier.wos000220027600002tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.journalPharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectThromboxane A(2)en_US
dc.subjectBlood pressureen_US
dc.subjectHemorrhagic shocken_US
dc.subjectCatecholamineen_US
dc.subjectSvasopressinen_US
dc.subjectRenin activityen_US
dc.subjectSympatho-adrenomedullary outflowen_US
dc.subjectParaventricular nucleusen_US
dc.subjectVasopressin secretionen_US
dc.subjectNitric-oxideen_US
dc.subjectCDP-cholineen_US
dc.subjectProstaglandinsen_US
dc.subjectActivationen_US
dc.subjectResponsesen_US
dc.subjectPerfusionen_US
dc.subjectReceptorsen_US
dc.subject.emtree15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic aciden_US
dc.subject.emtree7 [3 [(4 phenylsemicarbazido)methyl] 7 oxabicyclo[2.2.1]hept 2 yl] 5 heptenoic aciden_US
dc.subject.emtreeAdrenalinen_US
dc.subject.emtreeNoradrenalinen_US
dc.subject.emtreePrazosinen_US
dc.subject.emtreeVasopressinen_US
dc.subject.emtreeVasopressin receptor antagonisten_US
dc.subject.emtreeAdrenalin blood levelen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeBleedingen_US
dc.subject.emtreeBlood pressureen_US
dc.subject.emtreeBrainen_US
dc.subject.emtreeCardiovascular systemen_US
dc.subject.emtreeCentral nervous systemen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeHypotensionen_US
dc.subject.emtreeLateral brain ventricleen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMedulla oblongataen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeNoradrenalin blood levelen_US
dc.subject.emtreePeripheral nervous systemen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSolitary tract nucleusen_US
dc.subject.emtreeVasopressin blood levelen_US
dc.subject.mesh15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic aciden_US
dc.subject.meshAngiotensin II type 1 receptor blockersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshBrainen_US
dc.subject.meshCatecholaminesen_US
dc.subject.meshHeart rateen_US
dc.subject.meshHemodynamic processesen_US
dc.subject.meshHemorrhageen_US
dc.subject.meshHydrazinesen_US
dc.subject.meshHypotensionen_US
dc.subject.meshInjectionsen_US
dc.subject.meshInjections, intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshMedulla oblongataen_US
dc.subject.meshParaventricular hypothalamic nucleusen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReceptors, adrenergic, alpha-1en_US
dc.subject.meshReceptors, vasopressinen_US
dc.subject.meshReninen_US
dc.subject.meshShock, hemorrhagicen_US
dc.subject.meshSolitary nucleusen_US
dc.subject.meshThromboxane a2en_US
dc.subject.meshVasoconstrictor agentsen_US
dc.subject.meshVasopressinsen_US
dc.subject.scopusHistamine H4 Receptors; Thioperamide; Chlorpheniramine Maleateen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleRestoration of blood pressure by centrally injected U-46619, a thromboxane A(2) analog, in hemorrhaged hypotensive rats: Investigation of different brain areasen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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