Malign peritoneal mezotelyoma hastalarının retrospektif değerlendirilmesi
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Date
2020-03-24
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Bursa Uludağ Üniversitesi
Abstract
Mezotelyoma plevra, periton, perikard ve tunica vaginalisin serozal yüzeylerinden gelişen malignitedir. Özellikle asbest maruziyeti ile ilişkilendirilmiştir. Malign peritoneal mezotelyoma (MPM) plevral tutulumdan sonra ikinci sıklıkta görülür. Çalışmamızda MPM tanısı alan hastalarda demografik özelliklerin, kullanılan tedavi seçeneklerinin incelenmesi amaçlandı. Çalışmamızda 12 erkek, 4 kadın toplamda 16 hastanın medyan yaşı 66 (46-93) yıldı. 15 hasta epiteolid, 1 hasta bifazik histopatolojiye sahipti. 2 hastaya hipertermik intraperitoneal kemoterapi (HİPEK) yapılmıştı. Birinci seçim kemoterapi alan 16 hasta, ikinci seçim kemoterapi alan 13 hasta, üçüncü seçim kemoterapi alan 4 hasta, dördüncü seçim kemoterapi alan 1 hasta mevcuttu. Birinci seçim kemoterapi alan hastaların medyan progresyonsuz sağkalımı 14,4 ay (CI %95 7,4:21,4) saptandı. Hastaların medyan toplam sağkalımı 22,0 aydı (CI %95 16:27,9). Standart tedavi seçenekleri arasında olan sitoredüksiyon cerrahisi + HİPEK, sistemik kemoterapi ve immünoterapinin optimal kullanımı ve bu tedavilere uygun hasta seçimi için prospektif, multidispliner, daha fazla hasta sayısı içeren çalışmalara ihtiyaç vardır.
Malignant mesothelioma is a neoplasm that originates from the serosal membrane of pleura, peritoneum, pericardium, and tunica vaginalis. It has been particularly associated with exposure to asbestos. Malignant peritoneal mesothelioma (MPM) is the second most commonly encountered type of mesothelioma after pleura. In our study, we aimed to analyze the demographic characteristics and treatment options of the patients diagnosed with MPM. In our study, the median age of 16 patients (12 men and four women) was 66 (46-93) years. Fifteen patients had epithelioid, and one patient had biphasic histopathology. Hyperthermic intraperitoneal chemotherapy (HIPEC) was performed in 2 patients. There were 16 patients receiving first-line chemotherapy, 13 patients receiving second-line chemotherapy, four patients receiving third-line chemotherapy, and one patient receiving fourth-line chemotherapy. The median progression-free survival of patients receiving first-line chemotherapy was found 14.4 months (CI 95% 7.4: 21.4). The median overall survival of the patients was detected 22. months (CI 95% 16: 27.9%). In order to determine which group of patients will benefit from cytoreduction surgery+HIPEC or which group of patients should start with systemic chemotherapy or immunotherapy, there is a need for prospective, multidisciplinary studies and a more significant number of patients.
Malignant mesothelioma is a neoplasm that originates from the serosal membrane of pleura, peritoneum, pericardium, and tunica vaginalis. It has been particularly associated with exposure to asbestos. Malignant peritoneal mesothelioma (MPM) is the second most commonly encountered type of mesothelioma after pleura. In our study, we aimed to analyze the demographic characteristics and treatment options of the patients diagnosed with MPM. In our study, the median age of 16 patients (12 men and four women) was 66 (46-93) years. Fifteen patients had epithelioid, and one patient had biphasic histopathology. Hyperthermic intraperitoneal chemotherapy (HIPEC) was performed in 2 patients. There were 16 patients receiving first-line chemotherapy, 13 patients receiving second-line chemotherapy, four patients receiving third-line chemotherapy, and one patient receiving fourth-line chemotherapy. The median progression-free survival of patients receiving first-line chemotherapy was found 14.4 months (CI 95% 7.4: 21.4). The median overall survival of the patients was detected 22. months (CI 95% 16: 27.9%). In order to determine which group of patients will benefit from cytoreduction surgery+HIPEC or which group of patients should start with systemic chemotherapy or immunotherapy, there is a need for prospective, multidisciplinary studies and a more significant number of patients.
Description
16. Uludağ İç Hastalıkları Ulusal Kış Kongresi’nde (05 - 08 Mart 2020, Bursa) sözlü bildiri olarak sunulmuştur.
Keywords
Peritoneal mezotelyoma, Hipertermik İntraperitoneal kemoterapi, Sistemik kemoterapi, Sitoredüksiyon cerrahisi, Hyperthermic intraperitoneal, Peritoneal mesothelioma, Chemotherapy, Cytoreduction surgery, Systemic chemotherapy
Citation
Ocak, B. vd. (2020). ''Malign peritoneal mezotelyoma hastalarının retrospektif değerlendirilmesi''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(1),25-29.