Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation

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dc.contributor.buuauthorYılmaz, Mert
dc.contributor.buuauthorEner, Serdar
dc.contributor.buuauthorAkalın, Halis
dc.contributor.buuauthorSağdıç, Kadir
dc.contributor.buuauthorSerdar, Osman Akın
dc.contributor.buuauthorCengiz, Mete
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAF-5116-2019tr_TR
dc.date.accessioned2021-07-01T06:35:37Z
dc.date.available2021-07-01T06:35:37Z
dc.date.issued1999
dc.description.abstractThe systemic inflammatory response to cardiopulmonary bypass (CPB) is associated with increased production of cytokines. This systemic inflammatory response characterized by the activation of interleukin-6 (IL-6) and interleukin-8 (IL-8) during and after CPB is well documented. A prospective, randomized, double-blind study was performed so as to understand the effects of low-dose methyl prednisolone sodium succinate (MPSS) on the circulating levels of serum cytokines and clinical outcome. Twenty patients were randomly divided into two groups on the basis of the administration of low-dose(1 mg/kg) MPSS in = 10) and placebo in = 10) into the pump prime solution. All patients were scheduled to undergo a primary; elective coronary artery bypass grafting operation. Patients receiving concurrent corticosteroids, salicylates, dipyridamol or anticoagulants were excluded from the study. Other exclusion criteria were concurrent chronic obstructive pulmonary disease, chronic renal failure, insulin-dependent diabetes, congestive cardiac failure, peptic ulcer history, prior cardiac operations, recent tin a one-month period) myocardial infarction and steroid dependency. Mild systemic hypothermia (30-32 degrees C, rectal) was assured during the CPB. Four blood samples were drawn from the radial artery catheter immediately before starting CPB (T1), following protamine administration (T2) and at 24 (T3) and 48 h (T4) after completion of CPB. In each sample, creatine kinase-myocardial band (CK-MB), white blood cell (WBC), IL-6 and IL-8 levels were measured. IL-6 and IL-8 concentrations were measured by enzyme immunoassay and enzyme-linked immunoabsorbant assay methods.en_US
dc.identifier.citationYılmaz, M. vd. (1999). "Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation". Perfusion-UK, 14(3), 201-206.tr_TR
dc.identifier.endpage206tr_TR
dc.identifier.issn0267-6591
dc.identifier.issue3tr_TR
dc.identifier.pubmed10411250tr_TR
dc.identifier.scopus2-s2.0-0032982381tr_TR
dc.identifier.startpage201tr_TR
dc.identifier.urihttps://doi.org/10.1177/026765919901400308
dc.identifier.urihttps://journals.sagepub.com/doi/abs/10.1177/026765919901400308
dc.identifier.urihttp://hdl.handle.net/11452/20952
dc.identifier.volume14tr_TR
dc.identifier.wos000082332100008tr_TR
dc.language.isoenen_US
dc.publisherArnolden_US
dc.relation.journalPerfusion-UKen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectInterleukin-6en_US
dc.subjectMethylprednisoloneen_US
dc.subjectComplementen_US
dc.subjectGenerationen_US
dc.subjectPlasmaen_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.subject.wosPeripheral vascular diseaseen_US
dc.titleEffect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulationen_US
dc.typeArticle

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