Comparison of composite whole body insulin sensitivity index derived from mixed meal test and oral glucose tolerance test in insulin resistant obese subjects

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dc.contributor.authorDuran, Cevdet
dc.contributor.authorSelimoğlu, Hadi
dc.contributor.buuauthorKıyıcı, Sinem
dc.contributor.buuauthorGüçlü, Metin
dc.contributor.buuauthorErsoy, Canan
dc.contributor.buuauthorÖzkaya, Güven
dc.contributor.buuauthorErtürk, Erdinç
dc.contributor.buuauthorTuncel, Ercan
dc.contributor.buuauthorİmamoğlu, Sazi
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0297-846Xtr_TR
dc.contributor.researcheridABI-4847-2020tr_TR
dc.contributor.researcheridAAJ-6536-2021tr_TR
dc.contributor.researcheridAAH-8861-2021tr_TR
dc.contributor.researcheridA-4421-2016tr_TR
dc.contributor.scopusid12753880400tr_TR
dc.contributor.scopusid15073842600tr_TR
dc.contributor.scopusid6701485882tr_TR
dc.contributor.scopusid16316866500tr_TR
dc.contributor.scopusid7005488796tr_TR
dc.contributor.scopusid7006929833tr_TR
dc.contributor.scopusid6602297533tr_TR
dc.date.accessioned2021-12-17T11:35:21Z
dc.date.available2021-12-17T11:35:21Z
dc.date.issued2009-10
dc.description.abstractApart from fasting blood glucose (FBG) and insulin (FBI), oral glucose tolerance test (OGTT) is also used in calculating insulin sensitivity. During OGTT, insulin secretion may not reflect normal physiological insulin secretion. Based on this idea, hepatic and whole body insulin sensitivity rates were tested during OGTT and mixed meal test (MMT) in obese subjects. Thirty-one women with Quantitative Insulin Sensitivity Check Index (QUICKI) values below 0.350 and body mass index (BMI) a parts per thousand yen30 were included into the study. OGTT with 75-g glucose and MMT 300 kcal were applied to all cases. Data obtained from OGTT and MMT were used in the assessment of insulin sensitivity with Hemostasis of Model Assessment-Insulin Resistance (HOMA-IR) and Matsuda's Composite Whole Body Insulin Sensitivity Index (Matsuda's ISI). Mean BMI, FBG, and FBI were 36.8 +/- A 3.9 kg/m(2), 100.5 +/- A 0.10 mg/dl, 16.2 +/- A 5.3 mu g/ml, respectively. QUICKI was 0.31 +/- A 0.01 and HOMA-IR was 3.71 +/- A 0.88. Matsuda's ISI derived from OGTT was 6.96 +/- A 3.35 and from MMT was 11.32 +/- A 6.61. In analysis, it was demonstrated that there was a correlation between HOMA-IR, QUICKI, and Matsuda's ISIs derived from OGTT and MMT. Comparing the time periods separately, it was detected that despite similar increment in insulin levels, glucose levels were higher in OGTT than MMT at 15 and 30 min. Consequently, Matsuda's ISI was demonstrated to be effectively used with the data of MMT, as used with OGTT. Moreover, MMT was shown to be in parallel to physiologic insulin secretion and reflect pancreatic functions better compared to OGTT.en_US
dc.identifier.citationSelimoğlu, H. vd. (2009). "Comparison of composite whole body insulin sensitivity index derived from mixed meal test and oral glucose tolerance test in insulin resistant obese subjects". Endocrine, 36(2), 299-304.en_US
dc.identifier.endpage304tr_TR
dc.identifier.issn1355-008X
dc.identifier.issue2tr_TR
dc.identifier.pubmed19598007tr_TR
dc.identifier.scopus2-s2.0-73349100672tr_TR
dc.identifier.startpage299tr_TR
dc.identifier.urihttps://doi.org/10.1007/s12020-009-9213-z
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs12020-009-9213-z
dc.identifier.urihttp://hdl.handle.net/11452/23368
dc.identifier.volume36tr_TR
dc.identifier.wos000270169800018tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInsulin sensitivityen_US
dc.subjectMatsuda's insulin sensitivity indexen_US
dc.subjectMixed meal testen_US
dc.subjectObesityen_US
dc.subjectOral glucose tolerance testen_US
dc.subjectBeta-cell functionen_US
dc.subjectModelen_US
dc.subjectAciden_US
dc.subjectSecretionen_US
dc.subjectIncretinsen_US
dc.subjectReleaseen_US
dc.subjectEndocrinology & metabolismen_US
dc.subject.emtreeInsulinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArea under the curveen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeEatingen_US
dc.subject.emtreeEndocrine system examinationen_US
dc.subject.emtreeEvaluationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGlucose tolerance testen_US
dc.subject.emtreeHealth surveyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInsulin resistanceen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMethodologyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeObesityen_US
dc.subject.emtreePhysiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshArea under curveen_US
dc.subject.meshDiagnostic techniques, endocrineen_US
dc.subject.meshEatingen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucose tolerance testen_US
dc.subject.meshHealth status indicatorsen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulinen_US
dc.subject.meshInsulin resistanceen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshObesityen_US
dc.subject.scopusGlucose Tolerance Tests; Insulin Resistance; Acanthosis Nigricansen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.titleComparison of composite whole body insulin sensitivity index derived from mixed meal test and oral glucose tolerance test in insulin resistant obese subjectsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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