The relationship between c-erbB-2 oncogene expression and clinicopathological factors in gastric cancer

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dc.contributor.buuauthorGürel, S.
dc.contributor.buuauthorDolar, Mahmut Enver
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorSamlı, B.
dc.contributor.buuauthorÖztürk, H.
dc.contributor.buuauthorNak, Selim Giray
dc.contributor.buuauthorGülten, Macit
dc.contributor.buuauthorMemik, Faruk
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-9177-2021tr_TR
dc.date.accessioned2021-06-24T07:55:50Z
dc.date.available2021-06-24T07:55:50Z
dc.date.issued1999
dc.description.abstractGastric carcinoma is one of the most common carcinomas and a leading cause of death from cancer in Turkey. The relationship between clinicopathological features of the disease and oncogenes is under investigation. In this retrospective study we investigated the relationships between expression of c-erbB-2 oncoprotein and grade, stage and pathological characteristics of the tumour, and prognosis. Formalin-fixed, paraffin-embedded tissue sections were prepared from gastrectomy specimens from 55 patients with gastric carcinoma. The tissue sections were stained immunohistochemically to reveal c-erbB-2 protein. Six (10%) of the tumours stained positively for c-erbB-2 protein. There was no statistically significant association (P > 0.5) between c-erbB-2 staining and tumour grade, stage or pathological characteristics (necrosis, lymph-node infiltration), or between staining and prognosis. The results suggest that overexpression of c-erb-B-2 protein is not related to the pathological characteristics of the tumour in gastric carcinoma and is not an important prognostic indicator.en_US
dc.identifier.citationGürel, S. vd. (1999). "The relationship between c-erbB-2 oncogene expression and clinicopathological factors in gastric cancer". Journal of International Medical Research, 72(2), 74-78.en_US
dc.identifier.endpage78tr_TR
dc.identifier.issn0300-0605
dc.identifier.issue2tr_TR
dc.identifier.pubmed10446693tr_TR
dc.identifier.scopus2-s2.0-0344348912tr_TR
dc.identifier.startpage74tr_TR
dc.identifier.urihttps://doi.org/10.1177/030006059902700203
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/030006059902700203
dc.identifier.urihttp://hdl.handle.net/11452/20814
dc.identifier.volume27tr_TR
dc.identifier.wos000081397900003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherCambridge Med Publen_US
dc.relation.journalJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-erbB-2 oncoproteinen_US
dc.subjectGastric carcinomaen_US
dc.subjectClinicopathological featuresen_US
dc.subjectPrognosisen_US
dc.subjectHuman-breast-canceren_US
dc.subjectLong-term survivalen_US
dc.subjectGenetic alterationsen_US
dc.subjectOverexpressionen_US
dc.subjectAmplificationen_US
dc.subjectStomachen_US
dc.subjectAdenocarcinomaen_US
dc.subjectProteinen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleThe relationship between c-erbB-2 oncogene expression and clinicopathological factors in gastric canceren_US
dc.typeArticle
dc.wos.quartileQ3 (Medicine, research & experimental)en_US
dc.wos.quartileQ4 (Pharmacology & pharmacy)en_US

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