Effect of repeatedly given CDP-choline on cardiovascular and tissue injury in spinal shock conditions: Investigation of the acute phase

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dc.contributor.buuauthorCoşkun, Cenk Nuri
dc.contributor.buuauthorAvcı, Berrin
dc.contributor.buuauthorOcak, Nihal
dc.contributor.buuauthorYalçın, Murat
dc.contributor.buuauthorDirican, Melahat
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Temel Bilimler Bölümü.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridABE-6685-2020tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid23667159700tr_TR
dc.contributor.scopusid6603017388tr_TR
dc.contributor.scopusid23989248600tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.contributor.scopusid6601919847tr_TR
dc.contributor.scopusid6603687024tr_TR
dc.date.accessioned2022-03-25T05:56:45Z
dc.date.available2022-03-25T05:56:45Z
dc.date.issued2010-04
dc.description.abstractObjectives The protective effect of CDP-choline in spinal cord transection and the mediation of its cardiovascular effects were investigated. Methods Spinal cords of rats were transected at the T1-T2 levels. CDP-choline (250 mg/kg; intravenous) was administered 2 h and/or 24 h after the injury. Key findings Spinal cord transection caused severe tissue damage, decreased mean arterial pressure, heart rate, plasma adrenaline, and noradrenaline but increased plasma vasopressin levels. Repeated CDP-choline treatment attenuated the degree of tissue injury. Administration of CDP-choline at 2 h after transection transiently increased blood pressure and decreased heart rate, while it produced a small decrease in blood pressure and heart rate when it was given at 24 h. Plasma adrenaline levels were higher in the group where CDP-choline was given repeatedly. Plasma noradrenaline and vasopressin levels did not change additionally after CDP-choline injections in all groups. In order to determine if CDP-choline attenuates the oxidative injury induced by transection, we measured blood superoxide dismutase, glutathione peroxidase activity and malondialdehyde levels. Repeated CDP-choline administration decreased blood superoxide dismutase and glutathione peroxidase activity without any effect on malondialdehyde levels. Conclusions Data indicate that repeated intravenous CDP-choline treatment prevents tissue damage in spinal shock conditions in the acute phase. The cardiovascular effects of the drug do not seem to be responsible for this protection but the drug-induced attenuation of the oxidative stress may play a role.en_US
dc.identifier.citationCoşkun, C. vd. (2010). "Effect of repeatedly given CDP-choline on cardiovascular and tissue injury in spinal shock conditions: Investigation of the acute phase". Journal of Pharmacy and Pharmacology, 62(4), 497-506.en_US
dc.identifier.endpage506tr_TR
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158
dc.identifier.issue4tr_TR
dc.identifier.pubmed20604840tr_TR
dc.identifier.scopus2-s2.0-77952835497tr_TR
dc.identifier.startpage497tr_TR
dc.identifier.urihttps://doi.org/10.1211/jpp.62.04.0013
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1211/jpp.62.04.0013
dc.identifier.urihttp://hdl.handle.net/11452/25328
dc.identifier.volume62tr_TR
dc.identifier.wos000277102200013tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.bap2006/19tr_TR
dc.relation.journalJournal of Pharmacy and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatecholaminesen_US
dc.subjectCDP-cholineen_US
dc.subjectInjuryen_US
dc.subjectOxidative stressen_US
dc.subjectSpinal shocken_US
dc.subjectVasopressinen_US
dc.subjectCord-injuryen_US
dc.subjectBlood-pressureen_US
dc.subjectRegenerationen_US
dc.subjectInvolvementen_US
dc.subjectRegrowthen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.emtreeAdrenalinen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeNoradrenalinen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeVasopressinen_US
dc.subject.emtreeAdrenalin blood levelen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeAntioxidant activityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood pressure measurementen_US
dc.subject.emtreeBradycardiaen_US
dc.subject.emtreeCardiovascular diseaseen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHeart protectionen_US
dc.subject.emtreeMean arterial pressureen_US
dc.subject.emtreeNeuroprotectionen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeNoradrenalin blood levelen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeShocken_US
dc.subject.emtreeSpinal cord injuryen_US
dc.subject.emtreeSpinal cord transsectionen_US
dc.subject.emtreeSpinal shocken_US
dc.subject.emtreeVasopressin blood levelen_US
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleEffect of repeatedly given CDP-choline on cardiovascular and tissue injury in spinal shock conditions: Investigation of the acute phaseen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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