The hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqdeductal gray

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dc.contributor.authorMillington, William R.
dc.contributor.buuauthorÇavun, Sinan
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAC-9702-2019tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.contributor.scopusid6507468595tr_TR
dc.contributor.scopusid6508023759tr_TR
dc.date.accessioned2022-03-08T10:34:03Z
dc.date.available2022-03-08T10:34:03Z
dc.date.issued2004-09-03
dc.description.abstractThis study tested the hypothesis that the ventrolateral column of the midbrain periaqueductal gray (vlPAG) region mediates the hypotension and bradycardia evoked by visceral nociception. To test this, the local anesthetic lidocaine (2%; 0.5 mul) was microinjected into the vlPAG of halothane-anesthetized rats bilaterally and visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Acetic acid injection caused an abrupt fall in arterial pressure (-12.2 +/- 2.1 mm Hg) and heart rate (-37 +/- 93 bpm) lasting approximately 15 min. Lidocaine injection into the vlPAG prevented the fall in arterial pressure and heart rate completely. Cobalt chloride (5 mM; 0.2 or 0.5 mul) injection into the vlPAG also prevented nociceptive hypotension but it did not affect the fall in heart rate significantly. Lidocaine pretreatment also inhibited the depressor response caused by intramuscular formalin (5%; 0.2 ml) administration, a model of deep somatic nociception, although it did not prevent the response completely. To determine if opioid receptors mediate the response, selective mu, delta or kappa opioid receptor antagonists were microinjected into the vlPAG 5 min before intraperitoneal (ip) acetic acid administration. Naltrindole, a delta receptor antagonist, inhibited the response significantly but mu and kappa antagonists were completely ineffective. Lidocaine and naltrindole had no effect when injected into the dorsolateral PAG and did not influence cardiovascular function when injected into the vlPAG of saline treated control animals. These data support the hypothesis that the vlPAG mediates the depressor response evoked by visceral nociception and indicate that delta opioid receptors participate in the response.en_US
dc.identifier.citationÇavun, S. vd. (2004). “The hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqdeductal gray”. Brain Research, 1019(1-2), 237-245.en_US
dc.identifier.endpage245tr_TR
dc.identifier.issn0006-8993
dc.identifier.issue1-2tr_TR
dc.identifier.pubmed15306258tr_TR
dc.identifier.scopus2-s2.0-4043174740tr_TR
dc.identifier.startpage237tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2004.06.003
dc.identifier.urihttp://hdl.handle.net/11452/24907
dc.identifier.volume1019tr_TR
dc.identifier.wos000223710800027tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVisceral nociceptionen_US
dc.subjectPainen_US
dc.subjectCentral cardiovascular regulationen_US
dc.subjectPeriaqueductal grayen_US
dc.subjectOpioid receptoren_US
dc.subjectDelta receptoren_US
dc.subjectVentrolateral periaqueductal grayen_US
dc.subjectFos-like immunoreactivityen_US
dc.subjectColorectal distensionen_US
dc.subjectNoxious-stimulationen_US
dc.subjectArterial-pressureen_US
dc.subjectInduced analgesiaen_US
dc.subject5-HT1A receptorsen_US
dc.subjectEscapable painen_US
dc.subjectMidbrainen_US
dc.subjectMedullaen_US
dc.subjectNeurosciences and neurologyen_US
dc.subject.emtreeAcetic aciden_US
dc.subject.emtreeCobalt chlorideen_US
dc.subject.emtreeDelta opiate receptoren_US
dc.subject.emtreeDelta opiate receptor antagonisten_US
dc.subject.emtreeHalothaneen_US
dc.subject.emtreeKappa opiate receptor antagonisten_US
dc.subject.emtreeLidocaineen_US
dc.subject.emtreeLocal anesthetic agenten_US
dc.subject.emtreeMu opiate receptor antagonisten_US
dc.subject.emtreeNaltrindoleen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArterial pressureen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCardiovascular functionen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDepressor responseen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHypotensionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNociceptionen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePeriaqueductal gray matteren_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeVisceraen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHeart rateen_US
dc.subject.meshHypotensionen_US
dc.subject.meshMaleen_US
dc.subject.meshNarcotic antagonistsen_US
dc.subject.meshPain measurementen_US
dc.subject.meshPeriaqueductal grayen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, opioid, deltaen_US
dc.subject.scopusPeriaqueductal Gray; Animals; Escape Reactionen_US
dc.subject.wosNeurosciencesen_US
dc.titleThe hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqdeductal grayen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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