The effect of taurine supplementation on oxidative stress in experimental hypothyroidism

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dc.contributor.buuauthorTaş, Sibel
dc.contributor.buuauthorDirican, Melahat
dc.contributor.buuauthorSarandol, Emre
dc.contributor.buuauthorSerdar, Zehra
dc.contributor.departmentUludağ Üniversitesi/Fen Edebiyet Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.researcheridM-6142-2017tr_TR
dc.contributor.researcheridAAG-6985-2021tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridABE-6873-2020tr_TR
dc.date.accessioned2021-09-13T13:36:45Z
dc.date.available2021-09-13T13:36:45Z
dc.date.issued2006
dc.description.abstractThe purpose of this study was to investigate the oxidative status in experimental hypothyroidism and the antioxidant effect of taurine supplementation. Forty male Sprague Dawley rats were randomly divided into four groups (group 1, control; group 2, control + taurine; group 3, propylthiouracil (PTU); group 4, PTU + taurine). Hypothyroidism was induced by giving 0.05% PTU in drinking water for 8 weeks. Taurine was supplemented in drinking water at a concentration of 1 % for 5 weeks. Plasma (p < 0.05), red blood cell (p < 0.01), liver (p < 0.001) and kidney tissue (p > 0.05) malondialdehyde levels were increased in the PTU group compared with those of the control rats and were decreased in the PTU + taurine group compared with the PTU alone group. No significant changes were observed in glutathione levels of kidney and liver in the PTU group, but taurine supplementation significantly increased the glutathione levels of these tissues. Paraoxonase and arylesterase activities were decreased in the PTU group while taurine supplementation caused no significant changes in paraoxonase and arylesterase activities. These findings suggest that taurine supplementation may play a protective role against the increased oxidative stress resulting from hypothyroidism.en_US
dc.identifier.citationTaş, S. vd. (2006). ''The effect of taurine supplementation on oxidative stress in experimental hypothyroidism''. Cell Biochemistry and Function, 24(2), 153-158.en_US
dc.identifier.endpage158tr_TR
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue2tr_TR
dc.identifier.pubmed15617030tr_TR
dc.identifier.scopus2-s2.0-33645320285tr_TR
dc.identifier.startpage153tr_TR
dc.identifier.urihttps://doi.org/10.1002/cbf.1198
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbf.1198
dc.identifier.urihttp://hdl.handle.net/11452/21918
dc.identifier.volume24tr_TR
dc.identifier.wos000236399600010tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectCell biologyen_US
dc.subjectTaurineen_US
dc.subjectRaten_US
dc.subjectOxidative stressen_US
dc.subjectHypothyroidismen_US
dc.subjectSerumen_US
dc.subjectParaoxonaseen_US
dc.subjectSkeletal-muscleen_US
dc.subjectEnzyme-activitiesen_US
dc.subjectEnzyme-activitiesen_US
dc.subjectLiver-mitochondriaen_US
dc.subjectThyroid-dysfunctionen_US
dc.subjectAntioxidant defenseen_US
dc.subjectRat hepatocytesen_US
dc.subjectLipid-peroxidationen_US
dc.subjectHepatic glutathione synthesisen_US
dc.subject.scopusHyperthyroidism; Propylthiouracil; Levothyroxine Sodiumen_US
dc.subject.wosCell biologyen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.titleThe effect of taurine supplementation on oxidative stress in experimental hypothyroidismen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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