First-episode psychosis is associated with oxidative stress: Effects of short-term antipsychotic treatment

Simple item page
dc.contributor.buuauthorSarandöl, Aslı
dc.contributor.buuauthorSarandöl, Emre
dc.contributor.buuauthorAçıkgöz, Hacer Ebru
dc.contributor.buuauthorEker, Salih Saygın
dc.contributor.buuauthorAkkaya, Cengiz
dc.contributor.buuauthorDirican, Melahat
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Klinik Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridQ-9477-2019tr_TR
dc.contributor.scopusid14020405100tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.contributor.scopusid56800707200tr_TR
dc.contributor.scopusid14019347700tr_TR
dc.contributor.scopusid14061855100tr_TR
dc.contributor.scopusid6601919847tr_TR
dc.date.accessioned2022-06-13T08:07:55Z
dc.date.available2022-06-13T08:07:55Z
dc.date.issued2015-11
dc.description.abstractAimsIn the present study, our aim was to investigate the oxidative-antioxidative systems in unmedicated first-episode psychosis (FEP) patients at the beginning and after short-term treatment. MethodsThis study consisted of 29 patients who experienced an FEP and 25 control subjects. In order to investigate the oxidative status, we determined plasma malondialdehyde (MDA) levels, oxidizability of red blood cells, oxidation and oxidizability of apolipoprotein B-containing lipoproteins (apo B-basal MDA and apo B-MDA). In order to evaluate the antioxidative defense, we measured serum total antioxidative capacity, uric acid, albumin, total bilirubin and vitamin E levels and serum paraoxonase/arylesterase, whole blood glutathione peroxidase (GPx) and red blood cell superoxide dismutase activities before and after 6 weeks of treatment in patients with FEP. ResultsPlasma MDA and apo B-basal MDA levels and red blood cell superoxide dismutase activity were significantly higher and serum arylesterase and whole blood-GPx activities were lower in the FEP group than those of the healthy control group. There were not any significant changes in the oxidative and antioxidative system parameters (except increased vitamin E levels) after treatment. ConclusionsThe results of this study suggest that FEP is accompanied by oxidative stress. However, further studies are needed to clarify the role of oxidative stress in the physiopathologic mechanisms of FEP, so that oxidative and antioxidative system parameters can be used in the management of these patients. In accordance with psychiatric evaluation, for a better management, patients with FEP may require a multidisciplinary approach, including oxidative and antioxidative system parameters.en_US
dc.identifier.citationSarandöl, A. vd. (2015). "First-episode psychosis is associated with oxidative stress: Effects of short-term antipsychotic treatment". Psychiatry and Clinical Neurosciences, 69(11), 699-707.en_US
dc.identifier.endpage707tr_TR
dc.identifier.issn1323-1316
dc.identifier.issue11tr_TR
dc.identifier.pubmed26172069tr_TR
dc.identifier.scopus2-s2.0-84945458763tr_TR
dc.identifier.startpage699tr_TR
dc.identifier.urihttps://doi.org/10.1111/pcn.12333
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/pcn.12333
dc.identifier.urihttp://hdl.handle.net/11452/27089
dc.identifier.volume69tr_TR
dc.identifier.wos000363891900005tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalPsychiatry and Clinical Neurosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAffective disordersen_US
dc.subjectAntioxidanten_US
dc.subjectFirst-episode psychosisen_US
dc.subjectOxidative stressen_US
dc.subjectSchizophreniaen_US
dc.subjectLow-density-lipoproteinen_US
dc.subjectDrug-naive patientsen_US
dc.subjectAntioxidant defenseen_US
dc.subjectLipid peroxideen_US
dc.subjectSschizophreniaen_US
dc.subjectPlasmaen_US
dc.subjectOnseten_US
dc.subjectSusceptibilityen_US
dc.subjectDiseaseen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPsychiatryen_US
dc.subject.emtreeAlbuminen_US
dc.subject.emtreeAlpha tocopherolen_US
dc.subject.emtreeApolipoprotein Ben_US
dc.subject.emtreeAryldialkylphosphataseen_US
dc.subject.emtreeArylesteraseen_US
dc.subject.emtreeBilirubinen_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeNeuroleptic agenten_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeUric aciden_US
dc.subject.emtreeALB protein, humanen_US
dc.subject.emtreeAlpha tocopherolen_US
dc.subject.emtreeAPOB protein, humanen_US
dc.subject.emtreeApolipoprotein B100en_US
dc.subject.emtreeAryldialkylphosphataseen_US
dc.subject.emtreeArylesteraseen_US
dc.subject.emtreeBilirubinen_US
dc.subject.emtreeCarboxylesteraseen_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeNeuroleptic agenten_US
dc.subject.emtreeSerum albuminen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeUric aciden_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeClinical evaluationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeEnzyme blood levelen_US
dc.subject.emtreeErythrocyteen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeOxidationen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreePatient careen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreePsychosisen_US
dc.subject.emtreeShort course therapyen_US
dc.subject.emtreeVitamin blood levelen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeCase control studyen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeOxidation reduction reactionen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreePsychotic disordersen_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshAdulten_US
dc.subject.meshAntipsychotic agentsen_US
dc.subject.meshApolipoprotein B-100en_US
dc.subject.meshAryldialkylphosphataseen_US
dc.subject.meshBilirubinen_US
dc.subject.meshCarboxylic ester hydrolasesen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshErythrocytesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione peroxidaseen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshOxidation-reductionen_US
dc.subject.meshOxidative stressen_US
dc.subject.meshPsychotic disordersen_US
dc.subject.meshSerum albuminen_US
dc.subject.meshSuperoxide dismutaseen_US
dc.subject.meshUric aciden_US
dc.subject.meshVitamin Een_US
dc.subject.meshYoung adulten_US
dc.subject.scopusOxidative Stress; Acetylcysteine; Bipolar Disorderen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosNeurosciencesen_US
dc.subject.wosPsychiatryen_US
dc.titleFirst-episode psychosis is associated with oxidative stress: Effects of short-term antipsychotic treatmenten_US
dc.typeArticle
dc.wos.quartileQ3en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus