Tumor size predictive for malignancy in indeterminate follicular thyroid lesions

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dc.contributor.buuauthorDuran, Cevdet
dc.contributor.buuauthorSaraydaroğlu, Özlem
dc.contributor.buuauthorErsoy, Canan
dc.contributor.buuauthorSelimoğlu, Hadi
dc.contributor.buuauthorKıyıcı, Sinem
dc.contributor.buuauthorÖz, Özen
dc.contributor.buuauthorGüçlü, Metin
dc.contributor.buuauthorTuncel, Ercan
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorİmamoğlu, Sazı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-9701-2021tr_TR
dc.contributor.researcheridAAB-6174-2020tr_TR
dc.contributor.researcheridAAH-8861-2021tr_TR
dc.contributor.scopusid12754039000tr_TR
dc.contributor.scopusid15074395500tr_TR
dc.contributor.scopusid6701485882tr_TR
dc.contributor.scopusid15074185600tr_TR
dc.contributor.scopusid12753880400tr_TR
dc.contributor.scopusid15074213200tr_TR
dc.contributor.scopusid15073842600tr_TR
dc.contributor.scopusid7006929833tr_TR
dc.contributor.scopusid6603810549tr_TR
dc.contributor.scopusid6602297533tr_TR
dc.date.accessioned2021-12-13T05:33:41Z
dc.date.available2021-12-13T05:33:41Z
dc.date.issued2006
dc.description.abstractFine needle aspiration biopsy is of little value in distinguishing benign and malignant thyroid follicular neoplasms. In this study, we investigated clinical and histopathologic characteristics of cytologically indeterminate thyroid follicular lesions (ITFL) in attempt to predict malignancy as determined by histopathologic examination. Fifty-seven patients diagnosed with ITFL underwent thyroidectomy. The mean patient age was 50.4 +/- 13.4 years. Based on the histopathologic findings, cases were classified into 3 categories: nonfollicular lesion (NF), follicular adenoma (FA), and follicular carcinoma (FC). The NF group contained 19 subjects with nodular colloidal goiter (NCG), 3 with Hashimoto thyroiditis. and one with granulomatous thyroiditis. The FA group contained 7 classic follicular and 8 Hurtle cell adenomas. The FC group contained 6 classic follicular, 8 Hurtle cell, and one insular carcinoma. The mean nodule size was significantly larger in the FC group than in the FA and NF groups (4.2 +/- 2.4 cm vs 2.2 +/- 0.9 cm and 2.5 +/- 1.3 cm, respectively, P < 0.05). Using a value of nodule size of 3 cm, the sensitivity and specificity for solvent malignant histology are 66.7% and 83.3%, respectively. These data show that nodule size of ITFL is predictive of malignancy. A nodule size greater than 3 cm is associated with a higher probability of malignancy and suggests total thyroidectomy as an initial therapeutic intervention.en_US
dc.identifier.citationDuran, C. vd. (2006). ''Tumor size predictive for malignancy in indeterminate follicular thyroid lesions''. Endocrinologist, 16(6), 313-316.en_US
dc.identifier.endpage316tr_TR
dc.identifier.issn1051-2144
dc.identifier.issn1539-9192
dc.identifier.issue6tr_TR
dc.identifier.scopus2-s2.0-33751376587tr_TR
dc.identifier.startpage313tr_TR
dc.identifier.urihttps://doi.org/10.1097/01.ten.0000250222.52041.38
dc.identifier.urihttps://journals.lww.com/theendocrinologist/Fulltext/2006/11000/Tumor_Size_Predictive_for_Malignancy_in.5.aspx
dc.identifier.urihttp://hdl.handle.net/11452/23182
dc.identifier.volume16tr_TR
dc.identifier.wos000242498400005tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.journalEndocrinologisten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectThyroid canceren_US
dc.subjectSuspecten_US
dc.subjectIndeterminateen_US
dc.subjectFollicular lesionen_US
dc.subjectFollicular canceren_US
dc.subjectMarkersen_US
dc.subjectDiagnosisen_US
dc.subjectGalectin-3en_US
dc.subjectBenignen_US
dc.subjectNeoplasiaen_US
dc.subjectCarcinomaen_US
dc.subjectCytologyen_US
dc.subjectFine-needle-aspirationen_US
dc.subjectRisken_US
dc.subject.emtreeTumor volumeen_US
dc.subject.emtreeThyroidectomyen_US
dc.subject.emtreeThyroid noduleen_US
dc.subject.emtreeThyroid follicular carcinomaen_US
dc.subject.emtreeThyroid adenomaen_US
dc.subject.emtreeSensitivity and specificityen_US
dc.subject.emtreePredictionen_US
dc.subject.emtreeOncocytomaen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeCancer cytodiagnosisen_US
dc.subject.emtreeAspiration biopsyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAdulten_US
dc.subject.scopusThyroid Nodule; Fine Needle Aspiration Biopsy; Elasticity Imaging Techniquesen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.titleTumor size predictive for malignancy in indeterminate follicular thyroid lesionsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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