The effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy in brown layer chicks

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dc.contributor.authorSevimli, Alper
dc.contributor.authorUğuz, Cevdet
dc.contributor.buuauthorDeniz, Mısırlıoğlu
dc.contributor.buuauthorPolat, Ümit
dc.contributor.buuauthorYalçın, Murat
dc.contributor.buuauthorAkkoç, A. N.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Psikoloji Ana Bilim Dalı.tr_TR
dc.date.accessioned2021-08-31T13:05:36Z
dc.date.available2021-08-31T13:05:36Z
dc.date.issued2005-04
dc.description.abstractThe effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy were investigated. In this study, 175 1-day-old brown layer chicks were used. Throughout the study Group II ( vitamin A) received high doses of vitamin A ( 75 000 IU/kg), whereas Group I ( negative control), Group III ( positive control), Group IV ( pentoxyfylline) and Group V ( methylprednisolone) received normal levels of vitamin A in the diet. At the fifth week, the experimental Groups II, III, IV and V were injected with Freund's adjuvant intra-articularly to induce amyloid arthropathy. Group IV received pentoxyfylline and Group V received methylprednisolone ( 10 mg/kg, intramuscularly) once. Joint and blood samples were examined 13 weeks after the injections. The values in Groups I, II, III, IV and V, respectively, were as follows: amyloid arthropathy formation (%), 0, 100, 87, 76, 66; serum amyloid A (ng/ml), 1669/17, 607 +/- 40, 423 +/- 39, 342 +/- 27, 293 +/- 22; serum retinol (mu g/dl): 59.75 +/- 3.8, 42.72 +/- 3, 59.24 +/- 3.6, 102 +/- 9.1, 101.3 +/- 12.3; heterophil/lymphocyte ratio: 0.504, 0.75, 0.75, 0.087, 0.44. In conclusion, it was observed that vitamin A enhanced the development of amyloid arthropathy and there were positive associations between amyloidosis, increased levels of serum amyloid A and increased numbers of tissue infiltrating macrophages. Methylprednisolone had a more successful inhibitory effect on amyloid arthropathy than pentoxyfylline.en_US
dc.identifier.citationSevimli, A. vd. (2005). "The effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy in brown layer chicks". Avian Pathology, 34(2), 143-149.en_US
dc.identifier.endpage149tr_TR
dc.identifier.issn0307-9457
dc.identifier.issn1465-3338
dc.identifier.issue2tr_TR
dc.identifier.pubmed16191696tr_TR
dc.identifier.scopus2-s2.0-17844404835tr_TR
dc.identifier.startpage143tr_TR
dc.identifier.urihttps://doi.org/10.1080/03079450500059149
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/03079450500059149
dc.identifier.urihttp://hdl.handle.net/11452/21585
dc.identifier.volume34tr_TR
dc.identifier.wos000228834800011tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalAvian Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute-Phase Proteinen_US
dc.subjectNf-Kappa-Ben_US
dc.subjectRetinoic aciden_US
dc.subjectPrecursor proteinen_US
dc.subjectGene-expressionen_US
dc.subjectPhorbol esteren_US
dc.subjectInterleukin-1en_US
dc.subjectActivationen_US
dc.subjectInhibitionen_US
dc.subjectBindingen_US
dc.subjectVeterinary sciencesen_US
dc.subjectGallus gallusen_US
dc.subject.emtreeAntiinflammatory agenten_US
dc.subject.emtreeEnzyme inhibitoren_US
dc.subject.emtreeFreund adjuvanten_US
dc.subject.emtreeMethylprednisoloneen_US
dc.subject.emtreePentoxifyllineen_US
dc.subject.emtreeRetinolen_US
dc.subject.emtreeAmyloidosisen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeAnimal diseaseen_US
dc.subject.emtreeArthropathyen_US
dc.subject.emtreeBird diseaseen_US
dc.subject.emtreeChemically induced disorderen_US
dc.subject.emtreeChickenen_US
dc.subject.meshAmyloidosisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-inflammatory agentsen_US
dc.subject.meshChickensen_US
dc.subject.meshEnzyme inhibitorsen_US
dc.subject.meshFreund's adjuvanten_US
dc.subject.meshJoint diseasesen_US
dc.subject.meshMethylprednisoloneen_US
dc.subject.meshPentoxifyllineen_US
dc.subject.meshPoultry diseasesen_US
dc.subject.meshVitamin Aen_US
dc.subject.scopusSerum Amyloid A Protein; Amyloidosis; Amyloid Enhancing Factoren_US
dc.subject.wosVeterinary sciencesen_US
dc.titleThe effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy in brown layer chicksen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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