Endotoxin increases plasma leptin and ghrelin levels in dogs
dc.contributor.buuauthor | Yılmaz, Zeki | |
dc.contributor.buuauthor | Özarda, Yeşim | |
dc.contributor.buuauthor | Ulus, İsmail Hakkı | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-9836-0749 | tr_TR |
dc.contributor.researcherid | D-5340-2015 | tr_TR |
dc.contributor.researcherid | A-9637-2008 | tr_TR |
dc.contributor.researcherid | AAL-8873-2021 | tr_TR |
dc.contributor.scopusid | 35944810500 | tr_TR |
dc.contributor.scopusid | 35741320500 | tr_TR |
dc.contributor.scopusid | 7004271086 | tr_TR |
dc.date.accessioned | 2021-11-29T07:51:16Z | |
dc.date.available | 2021-11-29T07:51:16Z | |
dc.date.issued | 2008-03 | |
dc.description.abstract | Objective. Evaluations of plasma leptin and ghrelin levels and their relations with circulating levels of proinflammatory mediators, stress hormones, and biochemical markers of hepatorenal injury during experimental endotoxemia in dogs. Setting: Uludag University. Design: Placebo-controlled animal study. Animals, Adult mongrel dogs (n = 16). Interventions. Intravenous injection of endotoxin (1 mg/kg) and blood sample withdrawal before and at 0.5-48 hrs posttreatment. Measurements and Main Results. Mean baseline plasma leptin and ghrelin levels were 2.4 +/- 0.1 ng/mL and 867 +/- 58 pg/mL, respectively. Plasma leptin and ghrelin increased significantly by 16% (p <.05) and 72% (p <.001) at 0.5 hr, and they remained elevated by 33-41 % (p <.001) and 59-74% (p <.001) at 48 hrs after administration of endotoxin, respectively. There was positive correlation (r =.844; p <.001) between plasma leptin and ghrelin levels in endotoxin-treated dogs. Endotoxemia was associated with several-fold elevations in circulating levels of stress hormones, proinflammatory mediators, and hepatorenal injury markers. Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r =.955 and r =.890; p <.001), procalcitonin (r =.825 and r =.716; p <.001), cortisol (r =.823 and r =.786; p <.001), and hepatorenal injury markers (r =.580 to.745 and r =.393 to.574; p <.05 to.01). Conclusions. Circulating leptin and. ghrelin levels increase during endotoxemia, and these increases are associated with elevated levels of proinflarnmatory mediators, stress hormones, and serum biochemical markers for hepatorenal dysfunction. | tr_TR |
dc.identifier.citation | Yılmaz, Z. vd. (2008). ''Endotoxin increases plasma leptin and ghrelin levels in dogs''. Critical Care Medicine, 36(3), 828-833. | tr_TR |
dc.identifier.endpage | 833 | tr_TR |
dc.identifier.issn | 0090-3493 | |
dc.identifier.issn | 1530-0293 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.pubmed | 18431270 | tr_TR |
dc.identifier.scopus | 2-s2.0-44449134342 | tr_TR |
dc.identifier.startpage | 828 | tr_TR |
dc.identifier.uri | https://doi.org/10.1097/01.CCM.0B013E3181611F5AA | |
dc.identifier.uri | https://journals.lww.com/ccmjournal/Fulltext/2008/03000/Endotoxin_increases_plasma_leptin_and_ghrelin.24.aspx | |
dc.identifier.uri | http://hdl.handle.net/11452/22848 | |
dc.identifier.volume | 36 | tr_TR |
dc.identifier.wos | 000253450500023 | tr_TR |
dc.indexed.pubmed | Pubmed | tr_TR |
dc.indexed.scopus | Scopus | tr_TR |
dc.indexed.wos | SCIE | tr_TR |
dc.language.iso | en | tr_TR |
dc.publisher | Lippincott Williams & Wilkins | tr_TR |
dc.relation.journal | Critical Care Medicine | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | tr_TR |
dc.subject | Leptin | tr_TR |
dc.subject | Ghrelin | tr_TR |
dc.subject | Nitric oxide | tr_TR |
dc.subject | Procalcitonin | tr_TR |
dc.subject | Endotoxin | tr_TR |
dc.subject | Lipopolysaccharide | tr_TR |
dc.subject | Dog | tr_TR |
dc.subject | Platelet closure times | tr_TR |
dc.subject | Circulating leptin | tr_TR |
dc.subject | Serum leptin | tr_TR |
dc.subject | Lipopolysaccharide | tr_TR |
dc.subject | Sepsis | tr_TR |
dc.subject | Activation | tr_TR |
dc.subject | Expression | tr_TR |
dc.subject | Cytokines | tr_TR |
dc.subject | Responses | tr_TR |
dc.subject | Infusion | tr_TR |
dc.subject | General & internal medicine | tr_TR |
dc.subject.emtree | Endotoxin | tr_TR |
dc.subject.emtree | Ghrelin | tr_TR |
dc.subject.emtree | Hydrocortisone | tr_TR |
dc.subject.emtree | Leptin | tr_TR |
dc.subject.emtree | Nitric oxide | tr_TR |
dc.subject.emtree | Procalcitonin | tr_TR |
dc.subject.emtree | Stress hormone | tr_TR |
dc.subject.emtree | Ghrelin | tr_TR |
dc.subject.emtree | Leptin | tr_TR |
dc.subject.emtree | Animal experiment | tr_TR |
dc.subject.emtree | Animal model | tr_TR |
dc.subject.emtree | Article | tr_TR |
dc.subject.emtree | Controlled study | tr_TR |
dc.subject.emtree | Disease course | tr_TR |
dc.subject.emtree | Disease marker | tr_TR |
dc.subject.emtree | Endotoxemia | tr_TR |
dc.subject.emtree | Female | tr_TR |
dc.subject.emtree | Hormone blood level | tr_TR |
dc.subject.emtree | Hormone response | tr_TR |
dc.subject.emtree | Kidney injury | tr_TR |
dc.subject.emtree | Liver injury | tr_TR |
dc.subject.emtree | Male | tr_TR |
dc.subject.emtree | Nonhuman | tr_TR |
dc.subject.emtree | Priority journal | tr_TR |
dc.subject.emtree | Animal | tr_TR |
dc.subject.emtree | Blood | tr_TR |
dc.subject.emtree | Dog | tr_TR |
dc.subject.mesh | Animals | tr_TR |
dc.subject.mesh | Dogs | tr_TR |
dc.subject.mesh | Endotoxemia | tr_TR |
dc.subject.mesh | Female | tr_TR |
dc.subject.mesh | Ghrelin | tr_TR |
dc.subject.mesh | Leptin | tr_TR |
dc.subject.mesh | Male | tr_TR |
dc.subject.scopus | Ghrelin Receptors; Acyltransferases; Growth Hormone Releasing Hexapeptide | tr_TR |
dc.subject.wos | Critical care medicine | tr_TR |
dc.title | Endotoxin increases plasma leptin and ghrelin levels in dogs | tr_TR |
dc.type | Article | |
dc.wos.quartile | Q1 | tr_TR |
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