Primary small cell carcinoma of the breast: Report of seven cases and review of the literature

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dc.contributor.authorKılıçkap, Saadetin
dc.contributor.authorKorkmaz, Taner
dc.contributor.authorÖven, Bala Başak Ustaalıoğlu
dc.contributor.buuauthorKanat, Özkan
dc.contributor.buuauthorCanhoroz, Mustafa
dc.contributor.buuauthorÇubukçu, Erdem
dc.contributor.buuauthorTolunay, Şahsine
dc.contributor.buuauthorEvrensel, Türkkan
dc.contributor.buuauthorManavoğlu, Osman
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9732-5340tr_TR
dc.contributor.researcheridAAI-1612-2021tr_TR
dc.contributor.researcheridAAJ-1027-2021tr_TR
dc.contributor.scopusid55881548500tr_TR
dc.contributor.scopusid52663246200tr_TR
dc.contributor.scopusid53986153800tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.contributor.scopusid6603942124tr_TR
dc.contributor.scopusid6602587152tr_TR
dc.date.accessioned2021-12-29T10:25:10Z
dc.date.available2021-12-29T10:25:10Z
dc.date.issued2011-07
dc.description.abstractAims and background. The aim of the study was to analyze the clinicopathological characteristics, treatment modalities, and clinical outcome of patients with primary small cell carcinoma of the breast. Methods. Fifty-three cases of primary small cell carcinoma of the breast were identified; 7 cases in this series and 46 from the English-language medical literature. Results. There were 52 females and 1 male. The mean age was 53 years. Tumor size ranged from 1 to 18 cm (mean, 4.53). Axillary node metastasis was present in 61.7%. Only one patient had distant metastases at presentation. The presence of hormone receptors was reported in 24.5% of the tumors. Modified radical mastectomy was the most common surgical procedure and was performed in 50.9% of the patients. Adjuvant radiotherapy was administered to 39.6% of the patients, and 69.8% underwent chemotherapy. Thirteen percent of patients received adjuvant tamoxifen therapy. The mean follow-up was 20.75 months (range, 3-60), and 10 of 53 cases (18.9%) died of metastatic disease. Conclusions. The prognosis of primary small cell carcinoma of the breast largely depends on the initial stage of the disease. Multimodality treatment including surgery, radiotherapy and chemotherapy seems to be the most appropriate strategy for early disease. Chemotherapy is usually unsuccessful in treating metastatic disease.en_US
dc.identifier.citationKanat, O. vd. (2011). "Primary small cell carcinoma of the breast: Report of seven cases and review of the literature". Tumori Journal, 97(4), 473-478.en_US
dc.identifier.endpage478tr_TR
dc.identifier.issn0300-8916
dc.identifier.issn2038-2529
dc.identifier.issue4tr_TR
dc.identifier.pubmed21989436tr_TR
dc.identifier.scopus2-s2.0-80053633986tr_TR
dc.identifier.startpage473tr_TR
dc.identifier.urihttps://doi.org/10.1177/030089161109700410
dc.identifier.urihttps://journals.sagepub.com/doi/abs/10.1177/030089161109700410
dc.identifier.urihttp://hdl.handle.net/11452/23730
dc.identifier.volume97tr_TR
dc.identifier.wos000295956300010tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalTumori Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectBreasten_US
dc.subjectChemotherapyen_US
dc.subjectRadiotherapyen_US
dc.subjectSmall cell carcinomaen_US
dc.subjectSurgeryen_US
dc.subjectNeedle aspiration cytologyen_US
dc.subjectNeuroendocrine carcinomaen_US
dc.subject.emtreeBisphosphonic acid derivativeen_US
dc.subject.emtreeChromograninen_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeCyclophosphamideen_US
dc.subject.emtreeEpirubicinen_US
dc.subject.emtreeEstrogen receptoren_US
dc.subject.emtreeEtoposideen_US
dc.subject.emtreeFluorouracilen_US
dc.subject.emtreeNeuron specific enolaseen_US
dc.subject.emtreeProgesterone receptoren_US
dc.subject.emtreeSynaptophysinen_US
dc.subject.emtreeTamoxifenen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAxillary lymph nodeen_US
dc.subject.emtreeBone metastasisen_US
dc.subject.emtreeBrain metastasisen_US
dc.subject.emtreeBreast carcinomaen_US
dc.subject.emtreeCancer adjuvant therapyen_US
dc.subject.emtreeCancer combination chemotherapyen_US
dc.subject.emtreeCancer surgeryen_US
dc.subject.emtreeCancer survivalen_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeDistant metastasisen_US
dc.subject.emtreeExternal beam radiotherapyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeImmunoreactivityen_US
dc.subject.emtreeLymph node dissectionen_US
dc.subject.emtreeLymph node metastasisen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMultimodality cancer therapyen_US
dc.subject.emtreeMultiple cycle treatmenten_US
dc.subject.emtreeNeedle biopsyen_US
dc.subject.emtreeOutcome assessmenten_US
dc.subject.emtreeOverall survivalen_US
dc.subject.emtreePartial mastectomyen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeSmall cell carcinomaen_US
dc.subject.emtreeTumor localizationen_US
dc.subject.emtreeTumor necrosisen_US
dc.subject.emtreeTumor volumeen_US
dc.subject.scopusNeuroendocrine Carcinoma; Synaptophysin; Chromograninsen_US
dc.subject.wosOncologyen_US
dc.titlePrimary small cell carcinoma of the breast: Report of seven cases and review of the literatureen_US
dc.typeReview

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