Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk

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dc.contributor.buuauthorÖzarda, Yeşim
dc.contributor.buuauthorÖzbek, Resul
dc.contributor.buuauthorHamurtekin, Emre
dc.contributor.buuauthorUlus, Ismail H.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.date.accessioned2021-06-30T10:55:40Z
dc.date.available2021-06-30T10:55:40Z
dc.date.issued2005-08
dc.description.abstractThis study assessed the choline status in newborns, infants, children, breast-feeding women, breast milk, infant forinula, breast-fed and formula-fed infants. The serum free choline level was 35.1 +/- 1.1 mu mol/L at birth and decreased to 24.2 +/- 1.6, 18.1 +/- 0.8, 16.3 +/- 0.9, 14.3 +/- 0.8, 12.9+0.6 or 10.9 +/- 0.6 mu mol/L at 22-28, 151-180, 331-365, 571-730, 731-1095 or 4016-4380 days after birth, respectively. The serum phospholipid-bound choline level was 1997 +/- 75 mu mol/L at birth and increased gradually to 2315 +/- 190 or 2572 +/- 100 mu mol/L at 571-730 or 4016-4380 days after birth, respectively. In breast-feeding women, serum free and phospholipid-bound choline levels were doubled at 12-28 days after birth, they decreased toward the control values with time. Free choline, phosphocholine and glycerophosphocholine were major choline compounds in breast milk. Their concentrations in mature milk were much greater than in colostrum and serum. Choline contents of breast milk varied greatly between mothers, and milk free choline levels were correlated with serum free choline (r.541; P <.001), phospholipid-bound choline (r=.527; P <.001) and glycerophosphocho line (r=.299-1 P <.01) concentrations and lactating days (r=.520 - P <.001). In breast-fed infants, serum free choline concentrations were correlated with free choline (r.47; P <.001), phosphocholine (r=.345; P <.002), glycerophosphocholine (r=.311; P <.01) and total choline (r=.306; P <.01) contents of breast milk. Serum free choline concentration in formula-fed infants was lower than breast-fed infants. These data show that (a) circulating choline status is elevated during infancy and lactation, (b) choline contents of breast milk vary between mothers and milk free choline contents are influenced by maternal circulating choline status, and (c) the choline contents of breast milk can influence infants' circulating choline status.en_US
dc.identifier.citationÖzarda, Y. vd. (2005). "Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk". Journal of Nutritional Biochemistry, 16(8), 489-499.tr_TR
dc.identifier.endpage499tr_TR
dc.identifier.issn0955-2863
dc.identifier.issue8tr_TR
dc.identifier.pubmed16043031tr_TR
dc.identifier.scopus2-s2.0-22844433198tr_TR
dc.identifier.startpage489tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jnutbio.2005.01.011
dc.identifier.urihttp://hdl.handle.net/11452/20933
dc.identifier.volume16tr_TR
dc.identifier.wos000231265700004tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Nutritional Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlasma cholineen_US
dc.subjectIncreasesen_US
dc.subjectRaten_US
dc.subjectBrainen_US
dc.subjectPhosphatidylcholineen_US
dc.subjectSupplementationen_US
dc.subjectDietaryen_US
dc.subjectEstersen_US
dc.subjectLipidsen_US
dc.subjectFree cholineen_US
dc.subjectBreast-feeding womenen_US
dc.subjectPhospholipid-bound cholineen_US
dc.subjectGlycerophosphocholineen_US
dc.subjectPhosphocholineen_US
dc.subjectNewbornsen_US
dc.subjectInfantsen_US
dc.subjectBreast milken_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectNutrition & dieteticsen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosNutrition & dieteticsen_US
dc.titleCholine status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milken_US
dc.typeArticle
dc.wos.quartileQ2 (Biochemistry & molecular biology)en_US
dc.wos.quartileQ1 (Biochemistry & molecular biology)en_US

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