Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia

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dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.buuauthorEralp, Oya
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-4242-8609tr_TR
dc.contributor.orcid0000-0001-9836-0749tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.researcheridAAG-2943-2020tr_TR
dc.contributor.scopusid35944810500tr_TR
dc.contributor.scopusid24472964600tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.date.accessioned2021-12-01T08:32:31Z
dc.date.available2021-12-01T08:32:31Z
dc.date.issued2008-06
dc.description.abstractBackground: Platelets are of great importance in the pathogenesis of endotoxemia. Although thrombocytopenia is used as a diagnostic sign of endotoxemia, changes in values for platelet indices (plateletcrit [PCT], mean platelet volume [MPV], and platelet size distribution width [PDW]) in response to endotoxin are still unknown. Objective: The aim of this study was to evaluate platelet count and its relations with platelet indices in a canine model of endotoxemia. Methods: Twenty dogs were divided into 2 groups of 10 each, and treated intravenously with Escherichia coli endotoxin (1 mg/kg) or vehicle. Venous blood samples were collected before treatment (0 hour) and 0.5, 1, 2, 4, 6, 8, 12, and 24 hours after treatment. Platelet counts and indices were determined on a CELL-DYN hematology analyzer. Results: The platelet count and PCT decreased by a mean of 73% and 93%, respectively (P <.001), at 0.5 hour, and remained 70% and 85% lower than baseline values (P <.001) for 24 hours after endotoxin injection. MPV and PDW increased by a mean of 28% and 45%, respectively (P <.01), at 0.5 hour, and remained increased by 7% and 16% over baseline values for 24 hours (P <.01-.001). Platelet count correlated positively with PCT (P <.001), but correlated negatively with MPV (P <.001) and PDW (P <.01). Conclusions: Changes in platelet count and its association with platelet indices may reflect changes in platelet production and reactivity. Platelet indices have potential value in the diagnosis and monitoring of dogs and humans with endotoxemia.tr_TR
dc.identifier.citationYılmaz, Z. vd. (2008). ''Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia''. Veterinary Clinical Pathology, 37(2), 159-163.tr_TR
dc.identifier.endpage163tr_TR
dc.identifier.issn0275-6382
dc.identifier.issn1939-165X
dc.identifier.issue2tr_TR
dc.identifier.pubmed18533914tr_TR
dc.identifier.scopus2-s2.0-47649122356tr_TR
dc.identifier.startpage159tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1939-165X.2008.00023.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1939-165X.2008.00023.x
dc.identifier.urihttp://hdl.handle.net/11452/22926
dc.identifier.volume37tr_TR
dc.identifier.wos000256413500005tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoentr_TR
dc.publisherWileytr_TR
dc.relation.journalVeterinary Clinical Pathologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectVeterinary sciencestr_TR
dc.subjectCanis familiaristr_TR
dc.subjectEscherichia colitr_TR
dc.subjectMoroccan pepper virustr_TR
dc.subjectDogtr_TR
dc.subjectEndotoxintr_TR
dc.subjectMpvtr_TR
dc.subjectPcttr_TR
dc.subjectPdwtr_TR
dc.subjectPlatelettr_TR
dc.subjectSepsistr_TR
dc.subjectDogstr_TR
dc.subjectNumbertr_TR
dc.subjectDystr_TR
dc.subjectFunctiontr_TR
dc.subjectDiagnosistr_TR
dc.subject.emtreeLipopolysaccharidetr_TR
dc.subject.emtreeLipopolysaccharide, e coli O55 B5tr_TR
dc.subject.emtreeAnimaltr_TR
dc.subject.emtreeAnimal diseasetr_TR
dc.subject.emtreeArticletr_TR
dc.subject.emtreeBloodtr_TR
dc.subject.emtreeChemically induced disordertr_TR
dc.subject.emtreeCytologytr_TR
dc.subject.emtreeDogtr_TR
dc.subject.emtreeDog diseasetr_TR
dc.subject.emtreeEndotoxemiatr_TR
dc.subject.emtreeFemaletr_TR
dc.subject.emtreeMaletr_TR
dc.subject.emtreeThrombocytetr_TR
dc.subject.emtreeThrombocyte counttr_TR
dc.subject.emtreeTimetr_TR
dc.subject.meshAnimalstr_TR
dc.subject.meshBlood Plateletstr_TR
dc.subject.meshDog Diseasestr_TR
dc.subject.meshDogstr_TR
dc.subject.meshEndotoxemiatr_TR
dc.subject.meshFemaletr_TR
dc.subject.meshLipopolysaccharidestr_TR
dc.subject.meshMaletr_TR
dc.subject.meshPlatelet Counttr_TR
dc.subject.meshTime Factorstr_TR
dc.subject.scopusMean Platelet Volume; Blood Platelets; Erythrocyte Indicestr_TR
dc.subject.wosVeterinary sciencestr_TR
dc.titleEvaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemiatr_TR
dc.typeArticle
dc.wos.quartileQ2tr_TR

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