Determination of allelic deletion of multiple endocrine neoplasm type 1 (MEN1) gene in acute myeloid leukemia (AML) by application of FISH-TSA technique

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dc.contributor.authorAcar, Hasan
dc.contributor.authorKaynak, Murat
dc.contributor.authorUçar, Fahri
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Moleküler Biyoloji ve Genetik Anabilim Dalı.tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.date.accessioned2022-01-05T06:33:16Z
dc.date.available2022-01-05T06:33:16Z
dc.date.issued2002
dc.description.abstractWe have used the single and dual color fluorescence in situ hybridization (FISH) technique combined with a new detection system, tyramide signal amplification (TSA), by using the multiple endocrine neoplasm type I (MEN1) gene and chromosome I I specific alpha satellite DNA probes for the study of the allelic deletion of the MEN1 gene. The MEN1 gene is a new tumor supressor gene and has been recently cloned on chromosome 11q13. FISH combined with the TSA detection system was performed on bone marrow interphase nuclei of 22 patients with acute myeloid leukemia (AML). The FISH-TSA analysis revealed the mono allelic deletion of the MEN1 gene in 4 out of 22 patients (18.18%), 2 of 9 AML-M2 patients (22.2%), 1 of 6 AML-M4 patients (16.6%), and I of 4 AML-M5 patients (25.0%). Our study indicates that allelic deletion of the MEN1 gene is not a major cause or a primary event in tumorigenesis of AML, although the long arm (q13 region) of chromosome 11 involves a chromosomal rearrangement in AML.en_US
dc.identifier.citationAcar, H. vd. (2002). "Determination of allelic deletion of multiple endocrine neoplasm type 1 (MEN1) gene in acute myeloid leukemia (AML) by application of FISH-TSA technique". Teratogenesis Carcinogenesis and Mutagenesis, 22(5), 369-375.en_US
dc.identifier.endpage375tr_TR
dc.identifier.issn0270-3211
dc.identifier.issue5tr_TR
dc.identifier.pubmed12210500tr_TR
dc.identifier.scopus2-s2.0-0036025189tr_TR
dc.identifier.startpage369tr_TR
dc.identifier.urihttps://doi.org/10.1002/tcm.10033
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/tcm.10033
dc.identifier.urihttp://hdl.handle.net/11452/23855
dc.identifier.volume22tr_TR
dc.identifier.wos000177779100007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWiley Lissen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllelic deletionen_US
dc.subjectAMLen_US
dc.subjectFISHen_US
dc.subjectMEN1 geneen_US
dc.subjectTSAen_US
dc.subjectIn-situ hybridizationen_US
dc.subjectChromosome 11q13en_US
dc.subjectMll geneen_US
dc.subjectHeterozygosityen_US
dc.subjectAmplificationen_US
dc.subjectCarcinomasen_US
dc.subjectMutaionsen_US
dc.subjectRegionen_US
dc.subjectHeaden_US
dc.subjectOncologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectToxicologyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeDNAen_US
dc.subject.emtreeAcute granulocytic leukemiaen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAllelismen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeFluorescence in situ hybridizationen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeChromosome 11qen_US
dc.subject.emtreeColoren_US
dc.subject.emtreeUltrastructureen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDiagnostic accuracyen_US
dc.subject.emtreeDiagnostic valueen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFluorescence in situ hybridizationen_US
dc.subject.emtreeGene rearrangementen_US
dc.subject.emtreeGene deletionen_US
dc.subject.emtreeMen1 geneen_US
dc.subject.emtreeDNA probeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeAcute granulocytic leukemiaen_US
dc.subject.emtreeMultiple endocrine neoplasiaen_US
dc.subject.emtreeNucleic acid amplificationen_US
dc.subject.emtreeTumor suppressor geneen_US
dc.subject.emtreeTyramide signal amplificationen_US
dc.subject.emtreePreschool childen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAlleleen_US
dc.subject.emtreeChromosomeen_US
dc.subject.emtreeChromosome 11en_US
dc.subject.emtreeGeneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAdolescenten_US
dc.subject.meshChromosomesen_US
dc.subject.meshIn situ hybridization, fluorescenceen_US
dc.subject.meshAllelesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshMaleen_US
dc.subject.meshChromosomes, human, pair 11en_US
dc.subject.meshFemaleen_US
dc.subject.meshGene deletionen_US
dc.subject.meshHumanen_US
dc.subject.meshIn situ hybridization, fluorescenceen_US
dc.subject.meshLeukemia, myelocytic, acuteen_US
dc.subject.meshMaleen_US
dc.subject.meshSupport, non-U.S. gov'ten_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshChromosomesen_US
dc.subject.meshChromosomes, human, pair 11en_US
dc.subject.meshFemaleen_US
dc.subject.meshGene deletionen_US
dc.subject.meshHumansen_US
dc.subject.scopusMultiple Endocrine Neoplasia Type 1; Gastrinoma; Neuroendocrine Tumorsen_US
dc.subject.wosOncologyen_US
dc.subject.wosGenetics & heredityen_US
dc.subject.wosToxicologyen_US
dc.titleDetermination of allelic deletion of multiple endocrine neoplasm type 1 (MEN1) gene in acute myeloid leukemia (AML) by application of FISH-TSA techniqueen_US
dc.typeArticle
dc.wos.quartileQ3 (Toxicology)en_US
dc.wos.quartileQ4en_US

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