IgA vaskuliti tanılı olgularda klinik ve hematolojik parametrelerin ilişkisi
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Date
2020-10-15
Authors
Gökceoğlu, Arife Uslu
Sevim, Meliha
Abseyi, Sema Nilay
Journal Title
Journal ISSN
Volume Title
Publisher
Bursa Uludağ Üniversitesi
Abstract
IgA vaskuliti, çocukluk çağında en sık görülen vaskulit olmakla birlikte; gastrointestinal sistem ve renal tutulum olması hastalık seyrini etkilemektedir. Bu nedenle bu çalışmanın amacı retrospektif olarak başvuru anındaki hematolojik parametreler ile klinik bulgular ve organ tutulumu arasındaki ilişkiyi değerlendirmektir Çocuk Nefroloji Polikliniğinde IgA vaskuliti (HSP) tanısı alan çocuklar çalışmaya dahil edildi. Hastaların demografik bilgileri, klinik bulguları, laboratuar sonuçları ve ultrasonografi sonuçları kayıt edildi. Başvuru sırasındaki lökosit sayısı, trombosit sayısı, ortalama trombosit hacmi (MPV), eritrosit dağılım genişliği (RDW), total nötrofil sayısı, total lenfosit sayısı, sedimentasyon, C-reaktif protein (CRP), tam idrar tetkiki sonucunda hematüri ve/veya proteinüri varlığı, böbrek fonksiyon testleri ve ultrasonografi sonuçları kayıt edildi. Nötrofil/lenfosit oranı manuel hesaplandı. BULGULAR: Olguların %73’de eklem tutulumu, %52 ‘de organ tutulumu, %35’inde gastrointestinal sistem tutulumu, %20’de renal tutulum izlendi. Organ tutulumu olanlarda ve gastrointestinal sistem tutulumu olanlarda ortalama nötrofil ve nötrofil/lenfosit oranı anlamlı yüksek bulundu. Renal tutulumu olanlarda ortalama nötrofil sayısı, RDW ve CRP değerleri anlamlı yüksekti. Renal tutulum için erkek cinsiyet ve RDW değeri risk faktörü olarak saptandı. : IgA vaskulitinde başvurudaki hematolojik parametreler hastaların organ tutulumu, gastrointestinal sistem tutulumu ve renal tutulum açısından riskli olguları belirleyici olabilir. Özellikle nötrofil/lenfosit oranının organ tutulumu, gastrointestinal sistem tutulumu ve renal tutulumu olan olgularda daha yüksek olması hastalık patogenezinde nötrofillerin rolü olduğunu desteklemektedir. Renal tutulum için erkek cinsiyet ve artmış RDW değeri risk faktörleridir
IgA vasculitis is the most common vasculitis during childhood and gastrointestinal system involvement and renal involvement effect disease course. So we aim to evaluate the relationship between hematological parameters and clinic of patients diagnosed as IgA vasculitis. Study population included the children diagnosed as Ig A vasculitis in Pediatric Nephrology outpatient clinic. We recorded demographic information, clinical findings, laboratory results and ultrasonography results. Leucocyte count, thrombocyte count, mean platelet count (MPV), red cell distribution width (RDW), total neutrophil count, total lymphocyte count, sedimentation,C –reactive protein (CRP), hematuria and/or proteinuria, renal function tests and ultrasonography results were recorded. Ratio of neutrophil and lymphocyte was calculated. RESULTS: Of patients 73% had joint involvement, 52% had organ involvement, 35% had gastrointestinal system involvement, 20% had renal involvement. Mean neutrophil count and ration of neutrophil/lymphocyte were higher in patients with organ involvement than without organ involvement. Mean neutrophil count, RDW and CRP levels were higher in patients with renal involvement than without renal renal involvement. As a result hematological parameters at admission may predict oragan, gastrointestinal system and renal involvement. Especially higher neutophil and neutrophil/lymphocyte ratio in patients with organ, gastrointetinal system and renal involvement and higher RDW and CRP levels in patients with renal involvement were significant. Male sex and RDW levels were risk factors for renal involvement. Hematological parameters at admission may predict the cases with organ, gastrointestinal system and renal involvement. Especially higher ratio of neutrophil/lymphocyte in cases with organ, gastrointestinal system and renal involvement support the role of neutrophils in disease pathogenesis. Male sex and higher RDW levels were risk factors for renal involvement.
IgA vasculitis is the most common vasculitis during childhood and gastrointestinal system involvement and renal involvement effect disease course. So we aim to evaluate the relationship between hematological parameters and clinic of patients diagnosed as IgA vasculitis. Study population included the children diagnosed as Ig A vasculitis in Pediatric Nephrology outpatient clinic. We recorded demographic information, clinical findings, laboratory results and ultrasonography results. Leucocyte count, thrombocyte count, mean platelet count (MPV), red cell distribution width (RDW), total neutrophil count, total lymphocyte count, sedimentation,C –reactive protein (CRP), hematuria and/or proteinuria, renal function tests and ultrasonography results were recorded. Ratio of neutrophil and lymphocyte was calculated. RESULTS: Of patients 73% had joint involvement, 52% had organ involvement, 35% had gastrointestinal system involvement, 20% had renal involvement. Mean neutrophil count and ration of neutrophil/lymphocyte were higher in patients with organ involvement than without organ involvement. Mean neutrophil count, RDW and CRP levels were higher in patients with renal involvement than without renal renal involvement. As a result hematological parameters at admission may predict oragan, gastrointestinal system and renal involvement. Especially higher neutophil and neutrophil/lymphocyte ratio in patients with organ, gastrointetinal system and renal involvement and higher RDW and CRP levels in patients with renal involvement were significant. Male sex and RDW levels were risk factors for renal involvement. Hematological parameters at admission may predict the cases with organ, gastrointestinal system and renal involvement. Especially higher ratio of neutrophil/lymphocyte in cases with organ, gastrointestinal system and renal involvement support the role of neutrophils in disease pathogenesis. Male sex and higher RDW levels were risk factors for renal involvement.
Description
Keywords
Henosch Schönlein Purpurası, Henosch Schönlein Purpura, IgA vaskuliti, Nötrofil, C reaktif protein, Neutrophil, IgA vasculitis, C reactive protein
Citation
Gökçeoğlu, A. U. vd. (2020). "IgA vaskuliti tanılı olgularda klinik ve hematolojik parametrelerin ilişkisi". Bursa Uludağ Üniversitesi Güncel Pediatri, 18(3), 390-402.