Relationship between serum substance P levels and daytime sleepiness in obstructive sleep apnea syndrome

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dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorBurgazlıoğlu, Başak
dc.contributor.buuauthorErcan, İlker
dc.contributor.buuauthorGözü, R. Oktay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.orcid0000-0002-9027-1132tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid6601970351tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid15836471100tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.contributor.scopusid15836640800tr_TR
dc.date.accessioned2023-03-08T07:20:03Z
dc.date.available2023-03-08T07:20:03Z
dc.date.issued2007-01-12
dc.description.abstractObjective: We hypothesized that intermittent hypoxia might influence serum substance P levels, and that this effect might in turn contribute in excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea syndrome (OSAS). Patients and methods: Fifty-five patients with newly diagnosed OSAS and 15 age-matched nonapneic control subjects were enrolled in this study. Full polysomnography was performed in all patients. Single blood samples were drawn between 8:00 Am and 9:00 Am after the sleep study. Substance P levels were analyzed with a competitive enzyme immunoassay (substance P EIA kit; Cayman Chemical; Ann Arbor, MI). Results: There were no significant differences in age, gender, body mass index, smoking habit, and snoring between the two groups. Serum substance P levels in the OSAS group were significantly lower than that in the control group (p < 0.0001). Serum substance P levels were positively correlated with rapid eye movement sleep (r = 0.330, p = 0.049) and slow-wave sleep (r = 0.324, p = 0.049) phases. Serum substance P levels were negatively correlated with Epworth sleepiness scale score (r = - 0.253, p = 0.048), number of total apneas during the night (r = - 0.247, p = 0.036), number of respiratory events during the night (r = - 0.266, p = 0.024), apnea-hypopnea index (r = - 0.287, p = 0.015), respiratory arousal index (r = - 0.267, p 0.026), time spent in apnea and hypopnea (r = - 0.307, p 0.01), average oxygen desaturation (r=- 0.265, p = 0.026), and oxygen desaturation index (r=- 0.254, p = 0.031). Conclusion: We concluded that EDS seen in some of the OSAS patients might be associated with various pathophysiologic mechanisms including substance P levels.en_US
dc.identifier.citationUrsavaş, A. vd. (2007). "Relationship between serum substance P levels and daytime sleepiness in obstructive sleep apnea syndrome". Chest, 131(5), 1400-1405.en_US
dc.identifier.endpage1405tr_TR
dc.identifier.issn0012-3692
dc.identifier.issue5tr_TR
dc.identifier.pubmed17494790tr_TR
dc.identifier.scopus2-s2.0-34248582390tr_TR
dc.identifier.startpage1400tr_TR
dc.identifier.urihttps://doi.org/10.1378/chest.06-2348
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0012369215316093
dc.identifier.urihttp://hdl.handle.net/11452/31419
dc.identifier.volume131tr_TR
dc.identifier.wos000246544700022tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.journalChesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectFibromyalgiaen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectRespiratory systemen_US
dc.subjectSleepinessen_US
dc.subjectSubstance Pen_US
dc.subjectMetabolitesen_US
dc.subjectDepressionen_US
dc.subjectReceptorsen_US
dc.subjectSerotoninen_US
dc.subjectNeuronsen_US
dc.subjectSampleen_US
dc.subjectBrainen_US
dc.subjectRatsen_US
dc.subjectMenen_US
dc.subject.emtreeDaytime somnolenceen_US
dc.subject.emtreeSubstance Pen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeApneaen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeSlow wave sleepen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeHypoxiaen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeREM sleepen_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSleep apnea syndromeen_US
dc.subject.scopusNeurokinin-1 Receptors; Substance P; Senktideen_US
dc.subject.wosCritical care medicineen_US
dc.subject.wosRespiratory systemen_US
dc.titleRelationship between serum substance P levels and daytime sleepiness in obstructive sleep apnea syndromeen_US
dc.typeArticle
dc.wos.quartileQ1 (Respiratory system)en_US

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