Evaluation of diastolic dysfunction and repolarization dispersion in Behcet's disease

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dc.contributor.buuauthorGemici, Kani
dc.contributor.buuauthorBaran, İbrahim
dc.contributor.buuauthorGüllülü, Sümeyye
dc.contributor.buuauthorKazazoğlu, Ali Rıza
dc.contributor.buuauthorCordan, Jale
dc.contributor.buuauthorÖzer, Ziya
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUluda Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.tr_TR
dc.date.accessioned2021-06-29T10:25:23Z
dc.date.available2021-06-29T10:25:23Z
dc.date.issued2000-04-28
dc.description.abstractBehcet's disease is a generalized chronic inflammatory disease characterized by genital, ocular, and cardiovascular involvement. Recently, left ventricular diastolic dysfunction, ventricular arrhythmia and sudden cardiac death have been documented in Behcet's disease. From January 1996 to May 1998, we investigated left ventricular systolic and diastolic function, valvular heart disease, ischemic heart disease and repolarization dispersion in 71 cases, 40 men and 31 women (mean age, 36.8+/-10.3 years) with Behcet's disease. All of the results were compared with the control group of 33 men and 22 women (mean age, 37.9+/-9.6 years). Exercise stress test or myocardial perfusion scintigraphy was performed for the documentation of ischemia. All the patients and the controls were recorded by M-mode, 2-D and Doppler echocardiography. Ventricular wall thickness, valvular apparatus, left ventricular systolic and diastolic parameters were evaluated. Repolarization dispersion parameters were calculated as the difference between maximal and minimal values of QT from 12-lead electrocardiogram recording at baseline, immediate and end of recovery from the exercise stress tests. The measured parameters were compared with the control group by using statistical methods. In the Behcet's group of 22 patients (31%) EIA ratio was <1. In the control group of five cases (10%) E/A ratio was <1 (P=0.003), In the Behcet's group isovolumic relaxation time (IRT) and mitral deceleration time (MDT) were longer than the control group (P=0.002, P=0.041, respectively). A mean QT of 368+/-30 ms and mean QT dispersion of 73+/-14 ms in the patient group compared with a mean QT of 395+/-39 ms and mean QT dispersion of 38+/-12 ms in the controls. There was no statistical difference between the mean QT values of the patient and control groups however, ventricular dispersion parameters in the Behcet's patients were longer than in the controls (P<0.001). There was also statistical significance for the QT dispersion between the Behcet's patients with and without diastolic dysfunction (P<0.01). In conclusion, the study reveals that the patients with Behcet's disease have a high incidence of increased diastolic dysfunction and repolarization dispersion. A positive correlation may exist between diastolic dysfunction and QT dispersion.en_US
dc.identifier.citationGemici, K. vd. (2000). "Evaluation of diastolic dysfunction and repolarization dispersion in Behcet's disease". International Journal of Cardiology, 73(2), 143-148.en_US
dc.identifier.endpage148tr_TR
dc.identifier.issn0167-5273
dc.identifier.issue2tr_TR
dc.identifier.pubmed10817852tr_TR
dc.identifier.scopus2-s2.0-0034724754tr_TR
dc.identifier.startpage143tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0167-5273(00)00175-3
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0167527300001753
dc.identifier.urihttp://hdl.handle.net/11452/20901
dc.identifier.volume73tr_TR
dc.identifier.wos000087551500007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Irelanden_US
dc.relation.journalInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subjectBehcet's diseaseen_US
dc.subjectCardiac involvementen_US
dc.subjectDiastolic dysfunction and QT dispersionen_US
dc.subjectDoppler-echocardiographyen_US
dc.subjectQT dispersionen_US
dc.subjectM-modeen_US
dc.subjectIntervalen_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.titleEvaluation of diastolic dysfunction and repolarization dispersion in Behcet's diseaseen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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