Investigation of c-myc and p53 gene alterations in the tumor and surgical borderline tissues of NSCLC and effects on clinicopathologic behavior: By the FISH technique

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dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorGebitekin, Cengiz
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.researcheridAAE-1069-2022tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6602156436tr_TR
dc.date.accessioned2022-03-30T08:46:46Z
dc.date.available2022-03-30T08:46:46Z
dc.date.issued2003-09
dc.description.abstractGenetic alterations on the primary tumoral tissues and surgical borderline tissues of 51 patients with NSCLC on which radiotherapy and chemotherapy had not been performed were analyzed by using the FISH method with locus-specific probes for p53 tumor suppressor gene and c-myc oncogene and centromere-specific probes for chromosome 17 and chromosome 8 on which these genes are located. P53 deletions were detected in 7 patients (13.7%), c-myc amplification in 4 patients (7.8%), monosomy 17 in 2 patients (3.9%) and trisomy 8 in 3 patients (5.8%), and a high level of polyploidy in tumoral tissues of 6 patients (11.7%). P53 deletion and c-myc amplification were found at surgical borderlines of 2 patients and I patient, respectively. Although both p53 deletion and c-myc amplification have low frequency at surgical border tissues, not only their detection is important for the follow-up of recurrency and metastasis, but it is also important for genetical and pathological staging. The results of this study show that c-myc amplification in NSCLC is related to the shortening of survival (p < 0.01). C-myc amplification and p53 deletion are also effective for the occurrence of metastasis (p < 0.05) and the effect of c-myc amplification in this matter is much higher than p53 deletion. The gain or loss of copy number of chromosome 8 and monosomy 17 show parallel effects with c-myc amplification and p53 deletion, respectively, on the clinicopathological behavior of tumors.en_US
dc.identifier.citationYakut, T. vd. (2003). “Investigation of c-myc and p53 gene alterations in the tumor and surgical borderline tissues of NSCLC and effects on clinicopathologic behavior: By the FISH technique”. Lung, 181(5), 245-258.en_US
dc.identifier.endpage258tr_TR
dc.identifier.issn0341-2040
dc.identifier.issue5tr_TR
dc.identifier.pubmed14705768tr_TR
dc.identifier.scopus2-s2.0-0142187202tr_TR
dc.identifier.startpage245tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00408-003-1026-x
dc.identifier.urihttps://link.springer.com/article/10.1007/s00408-003-1026-x
dc.identifier.urihttp://hdl.handle.net/11452/25436
dc.identifier.volume181tr_TR
dc.identifier.wos000186180600002tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.journalLungen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRespiratory systemen_US
dc.subjectNSCLCen_US
dc.subjectC-mycen_US
dc.subjectP53en_US
dc.subjectFishen_US
dc.subjectSurgical borderlineen_US
dc.subjectCell lung-canceren_US
dc.subjectIn-situ hybridizationen_US
dc.subjectAmplificationen_US
dc.subjectMutationsen_US
dc.subjectCarcinomaen_US
dc.subjectFamilyen_US
dc.subjectExpressionen_US
dc.subjectProteinen_US
dc.subjectLinesen_US
dc.subjectRasen_US
dc.subject.emtreeProtein p53en_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer recurrenceen_US
dc.subject.emtreeCancer stagingen_US
dc.subject.emtreeCancer survivalen_US
dc.subject.emtreeCancer tissueen_US
dc.subject.emtreeChromosome 17en_US
dc.subject.emtreeChromosome 8en_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFluorescence in situ hybridizationen_US
dc.subject.emtreeGene amplificationen_US
dc.subject.emtreeGene deletionen_US
dc.subject.emtreeGene locationen_US
dc.subject.emtreeGene probeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeLung non small cell canceren_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetastasisen_US
dc.subject.emtreeMonosomyen_US
dc.subject.emtreeMutationen_US
dc.subject.emtreeOncogene c mycen_US
dc.subject.emtreePolyploidyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeTrisomyen_US
dc.subject.emtreeTumor suppressor geneen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, non-small-cell lungen_US
dc.subject.meshChromosomes, human, pair 17en_US
dc.subject.meshChromosomes, human, pair 8en_US
dc.subject.meshGenes, mycen_US
dc.subject.meshGenes, p53en_US
dc.subject.meshHumansen_US
dc.subject.meshIn situ hybridization, fluorescenceen_US
dc.subject.meshLung neoplasmsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshSurvival analysisen_US
dc.subject.scopusNon-Small Cell Lung Carcinoma; Lung Neoplasms; Mutationen_US
dc.subject.wosRespiratory systemen_US
dc.titleInvestigation of c-myc and p53 gene alterations in the tumor and surgical borderline tissues of NSCLC and effects on clinicopathologic behavior: By the FISH techniqueen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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