Ghrelin, leptin, adiponectin, and resistin levels in sleep apnea syndrome: Role of obesity

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dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorNalcı, Nazan
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorEge, Ercüment
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9027-1132tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid24448320900tr_TR
dc.contributor.scopusid6601970351tr_TR
dc.contributor.scopusid6701341320tr_TR
dc.date.accessioned2021-12-09T08:30:28Z
dc.date.available2021-12-09T08:30:28Z
dc.date.issued2010-07
dc.description.abstractAim: The aim of this study was to investigate the relationship among plasma leptin, ghrelin, adiponectin, resistin levels, and obstructive sleep apnea syndrome (OSAS). Methods: Fifty-five consecutive newly diagnosed OSAS patients and 15 age-matched nonapneic controls were enrolled in this study. After sleep study between 8:00 AM and 9:00 AM on the morning, venous blood was obtained in the fasting state to measure ghrelin and adipokines. Results: Serum ghrelin levels of OSAS group were significantly (P < 0.05) higher than those of the control group. No significant difference was noted in the levels of leptin, adiponectin, and resistin in OSAS group when compared to controls. There was a significant positive correlation between ghrelin and apnea-hypopnea index (AHI) (r = 0.237, P < 0.05) or the Epworth sleepiness scale (ESS) (r = 0.28, P < 0.05). There was also a significant positive correlation between leptin and body mass index (r = 0.592, P < 0.0001). No significant correlation was observed between leptin, adiponectin, resistin, and any polysomnographic parameters. Conclusion : Our findings demonstrated that serum ghrelin levels were higher in OSAS patients than those of control group and correlated with AHI and ESS. Further studies are needed to clarify the complex relation among OSAS, obesity, adipokines, and ghrelin.en_US
dc.identifier.citationUrsavaş, A. vd. (2010). "Ghrelin, leptin, adiponectin, and resistin levels in sleep apnea syndrome: Role of obesity". Annals of Thoracic Medicine, 5(3), 161-165.en_US
dc.identifier.endpage165tr_TR
dc.identifier.issn1817-1737
dc.identifier.issue3tr_TR
dc.identifier.pubmed20835311tr_TR
dc.identifier.scopus2-s2.0-77954835095tr_TR
dc.identifier.startpage161tr_TR
dc.identifier.urihttps://doi.org/10.4103/1817-1737.65050
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20835311/
dc.identifier.urihttp://hdl.handle.net/11452/23124
dc.identifier.volume5tr_TR
dc.identifier.wos000282023100008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWolters Kluweren_US
dc.relation.journalAnnals of Thoracic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipokinesen_US
dc.subjectObesityen_US
dc.subjectSleep apneaen_US
dc.subjectHypopnea syndromeen_US
dc.subjectSubclinical inflammationen_US
dc.subjectInsulin-resistanceen_US
dc.subjectMetabolic syndromeen_US
dc.subjectRisken_US
dc.subjectHormoneen_US
dc.subjectHumansen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subjectRespiratory systemen_US
dc.subject.emtreeAdipocytokineen_US
dc.subject.emtreeAdiponectinen_US
dc.subject.emtreeGhrelinen_US
dc.subject.emtreeLeptinen_US
dc.subject.emtreeResistinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeApnea hypopnea indexen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood levelen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeDiet restrictionen_US
dc.subject.emtreeEpworth sleepiness scaleen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeObesityen_US
dc.subject.emtreePolysomnographyen_US
dc.subject.emtreeSleep apnea syndromeen_US
dc.subject.emtreeStatistical significanceen_US
dc.subject.emtreeVenous blooden_US
dc.subject.scopusObstructive Sleep Apnea; Positive End Expiratory Pressure; Polysomnographyen_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.subject.wosRespiratory systemen_US
dc.titleGhrelin, leptin, adiponectin, and resistin levels in sleep apnea syndrome: Role of obesityen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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